Pneumocystis Pneumonia after Kidney Transplantation in Children

황수진,정지원,이주훈,박영서 대한소아신장학회 2020 Childhood kidney diseases Vol.24 No.1

Pneumocystis pneumonia (PCP) is a rare disease in healthy people but a potentially fatal opportunistic infection by Pneumocystis jirovecii in immunocompromised patients with organ transplantation. We present three cases of PCP after kidney transplantation in pediatric patients. First case was a 4-year-old boy diagnosed with Denys-Drash syndrome and received living-donor kidney transplantation from his mother at age of 1. Second case was a 19-year-old male, with polycystic kidney disease, who received kidney transplantation from his mother at the age of 18. Third case was a 19-year-old female with chronic kidney disease of unknown etiology, who received kidney transplantation from her father at age of 15. These three patients who were on immunosuppressive therapy and completed of routine PCP prophylaxis for 6 months had presented with cough and dyspnea more than 1 year after transplantation. Chest x-ray all showed diffuse haziness of both lung fields, and bronchoalveolar lavage from bronchoscopy revealed Pneumocystis jirovecii infection. All patients showed clinical resolution with intravenous trimethoprim-sulfamethoxazole (TMP-SMX) therapy for at least 3 weeks and had continued secondary prophylaxis for another 6–12 months. This report suggests that clinicians should have suspicion for the possibilities of opportunistic infection such as PCP after kidney transplantation in children.

Dexamethasone으로 유도한 근위축 세포모델에서 흑효모 배양물 유래 polycan의 근위축 개선에 대한 효과

황수진,임종민,구본화,천다미,정유진,김영숙,오태우 대한한의학방제학회 2021 大韓韓醫學方劑學會誌 Vol.29 No.1

Objectives : This study was conducted to evaluate the anti-atrophic effect of polycan in dexamethasone-induced skeletal muscle atrophy in vitro model. Methods : C2C12 myoblast were differentiated into myotube by 2% horese serum medium for 6 days, and then treated polycan extract at different concentrations for 24h. The effect of dexamethasone on the induction of muscle atrophy and expression of atrophy-related genes in differentiated C2C12 myotubes using a GSH, ROS, real-time PCR, western blots analysis. Results : The results showed that Treatment with polycan (100 and 200 ㎍/㎖) noncytotoxic levels on both myoblast and myotube. Polycan decreased the ROS level overproduced with dexamethasone and improved the depletion of GSH level. Dexamethasone showed a decrease in myotube diameter, which was associated with up-regulation muscle-specific ubiquitin ligases markers, such as atrogin-1, FoxO3, myostatin and muscle RING finger-1 (MuRF1), and down-regulation of myogenin, MEF2, Myogenic regulatory factor 5, 6 and MyoD. The results showed that polycan treatment significantly dose-dependently inhibited it. Furthermore, decreased expressions of PI3K/Akt signal pathway by dexamethasone were reversed by treatment with polycan. Conclusions : Thus, polycan suppresses dexamethasone induced muscle atrophy in C2C12 myotube in vitro model through activation of PI3K/Akt pathway and protective effect of improve skeletal muscle function.

흡연과 주거환경이 초등학생 천명 및 천식 발생에 미치는 영향

황수진,김정호,정선희,박동혁,심재원,김덕수,정혜림,박문수,심정연 대한 소아알레르기 호흡기학회 2010 Allergy Asthma & Respiratory Disease Vol.20 No.4

Purpose:Environmental factors may increase risk for childhood asthma. The objective of this study was to investigate the association of environmental tobacco smoke (ETS) exposure and home environment with the development of wheeze and asthma. Methods:We conducted a cross-sectional survey of 969 elementary school students. Data included questions about asthma and wheeze symptoms, exposure to tobacco smoke, and home environment including history of moving into a new house within 1 year of age after birth, use of fragrance at home, recent purchase of new furniture. Logistic regression and Pearson chi statistics were used to estimate these associations. Results:ETS exposure was associated with current wheeze and nocturnal sleep disturbance. Paternal smoking over 20 cigarettes per day was associated with 4 or more episodes of wheeze during the past 1 year. However, there were no significant differences in pulmonary function, serum total IgE levels, blood eosinophil counts, and atopy between children with ETS exposure and non- exposure. Moving into a new house within 1 year of birth was associated with current asthma or wheeze. Use of fragrance at home and purchase of new furniture during the past 1 year were associated with current wheeze, current physician-diagnosed asthma, and nocturnal cough. Conclusion:Exposure to ETS, moving into a new house after birth, and indoor fragrance are risk factors for wheeze and asthma in schoolchildren. 목 적:여러 환경적 요인이 천식 발생을 증가시킨다고 보고되고 있어 본 연구에서는 간접흡연과 주거 환경이 천명, 천식 발생에 미치는 영향과 천식의 위험 인자를 알아보고자 하였다. 방법:서울의 한 초등학교 학생 969명을 대상으로 설문 조사를 하였다. 설문 조사에는 천식, 천명의 증상, 간접흡연 노출, 주거환경에 관한 내용이 있었고, 주거환경과 관련된 항목들 중에는 출생 후 1년 이내 새로 지은 집으로 이사한 적이 있는지, 부모님이 향수를 집안에서 사용하는지, 최근 1년 이내 새 가구를 들여놓았는지 등이 포함되어 있다. Logistic regression and Pearson chi statistics를 사용하여 분석하였다. 결과:간접흡연에의 노출은 최근 1년 내 천명, 최근 1년 내 천명으로 잠에서 깨어난 것과 연관성이 있었다. 아버지의 하루 20개피 이상 흡연은 최근 12개월 이내 4회 이상의 천명과 연관이 있었다. 그러나 간접 흡연에 따른 폐기능, 총 IgE 농도, 알러젠 감작, 호산구수는 차이가 없었다. 출생 후 1년 이내 새집으로의 이사는 지금까지의 천식 진단과 연관이 있었고, 집안에서 향수를 사용하는 것과 최근 1년 이내 새가구를 사용하는 것은 최근 12개월 이내 천명 및 천식 치료, 야간 기침과 관련이 있었다. 결론:간접흡연, 출생 후 1년 이내 새집으로 이사, 향수 사용과 새가구 사용은 초등학생에서 천명 및 천식의 위험 요인이다.

유아의 나무 그리기 활동의 의미 탐색-만 5세반 유아를 대상으로-

황수진,김은주 부산대학교 교육발전연구소 2015 교육혁신연구 Vol.25 No.1

본 연구는 유아의 나무 그리기 활동의 의미를 알아보기 위하여 부산시에 위치한 B어린이집의 만 5세아 26명을 연구 참여자로 선정하였다. 2014년 3월 첫째 주부터 2014년 11월 첫째 주까지 B어린이집 만 5세반의 오전 10시 20분에서 12시 00분까지의 산책 활동에서 나타나는 나무 그리기 활동을 관찰 및 비디오 녹화를 하여 자료를 수집하였다. 또한 유아들과 비형식적 면담을 실시하며 연구일지를 작성하였다. 나무 그리기 활동은 첫째, 유아에게 ‘자연에 한 걸음 더 다가가기’의 의미가 있었다. 유아는 나무 그리기 활동을 통해 같은, 또 다른 나무의 모습을 발견하면서 나무를 친구처럼 여기며 나무 주변의 생명체와 날씨, 계절을 만나게 되었다. 둘째, 유아에게 나무 그리기 활동은 ‘타인과 한 걸음 더 가까워지기’의 의미가 있었다. 유아들은 친구 나무에 관심을 가지며 친구와 대화를 나누게 되었고 이러한 활동 속에서 유아들은 놀며, 그리며 친구와 친하게 지내는 모습을 볼 수 있었다. 셋째, ‘나를 한 걸음 더 들여다보기’로 유아는 나무 그리기 활동에서 유아 내면에 있는 감정을 느끼며 자신을 들여다보게 되었다. 나아가 이를 통해 나무와 나무 주변의 생명까지 소중히 여기고 배려하며 존중하게 되었다. The purpose of this study was to examine the meaning of a tree-drawing activity among preschoolers. as there are plenty of trees that preschoolers can see both in their neighborhood and in nature. A tree-drawing activity refers in this study to an activity that preschoolers select their own trees while taking a walk, observe them and draw them. A research question was posed: What is the meaning of the tree-drawing activity by five-year-old children? The subjects in this study were 26 preschoolers in a class of western age five in a daycare center located in an urban community. Data were gathered by making a participant observation in 31 sessions from the first week of March to the first week of November, 2014. The collected data involved a research journal, the drawings and writings of the preschoolers, informal interview data with the preschoolers and formal and informal interview data with the teacher who was the assistant observer. The collected data were analyzed to see what phenomena repeatedly appeared in the data, and the selected phenomena were categorized. The findings of the study were as follows: First, the preschoolers were able to keep being with nature while they engaged in the tree-drawing activity, which could be called “taking a step toward nature.” Second, people who got to bond with them became their friends who drew trees together, which could be called “taking a step toward others.” Third, the preschoolers were able to express themselves and look into themselves while they engaged in the tree-drawing activity, which could be called “taking a look at oneself.” The findings of the study show that the tree-drawing activity enabled the preschoolers to esteem life, to be considerate of it, to have close relationship with their friends, to be aware of their own emotion and to look back on themselves.

三國時代 嶺南 出土 札甲의 硏究

황수진 한국고고학회 2011 한국고고학보 Vol.78 No.-

In this paper, recognizing that the study of armour has focused on vertical plate armour and that the study of lamellar armour has been insufficient, I undertake a study of lamellar armour focusing on its overall aspect, as comprised of all parts. There are no common terms for the parts due to the lack of systematic research. Therefore, in examining terms and section names which have been confused, I present essential section names derived from hanbok. I maintain that lamellar armour consists of body armour and attached armour and further separate the armour into waist lamellar, body lamellar, upper arm lamellar, skirt lamellar, neck protector, arm protector, upper leg protector, and lower leg protector. In the third section of this paper, I attempt typological classification based on armour sections. The primary standards for classification are the form of the waist lamellar, the connecting method of the body lamellar, the existence of upper arm lamellar and skirt lamellar,and changes in the manufacturing techniques of neck and arm protectors. The upper and lower leg protector could not be studied as examples of such have yet to be found. After typological classification, I established five types based on the composition of parts as identified through excavation. Through the results of the typological classification and the selection of attributes which reflect temporal change, I separate the phrases and establish the ages. Lamellar armour was thus separated into five stages. The appearance of the A-type lamellar armour, the appearance the B-type lamellar armour, the disappearance of the A-type lamellar armour and the transition to the C-type lamellar armour, the progressive adoption of the III-type waist lamellar and the use of various types of lamellar armour as grave goods in the Youngnam area, the materialization of the IV-type waist lamellar and the golden-craft conversion of the lamellar armour are the epoch-making events. In the fourth section, I examine spatial distribution according to diachronic change. The first stage was a period in which A-type lamellar armour was buried in Busan and Gyeongju. It is thought that they were connected to one another, but there is a difference between the two in the first and second stages, as can be identified through the examination of burial contexts. Rather, there is a connection between Busan and Gimhae. In the second stage, it is recognized that there was technical interchange between the two regions, and that the Busan-type vertical plate armour appeared. But there was no interchange in the case of lamellar armour. The third stage, which is the period after the southern conquest of Goguryeo in 400 AD, shows a confused strain. With the collapse of the Daesungdong group, A-type lamellar armour disappeared and there is no lamellar armour of completion. In the fourth stage, lamellar armour of completion appears and D2-type lamellar armour is excavated in the areas of Busan and Gyeongsan. In this stage, Busan, which was the only area in which lamellar armour of completion was not buried, was not yet included in Silla and still exercised influence. In the fifth stage, IV-type lamellar appeared, coexisting with III-type waist lamellar. The IV-type waist lamellar(Ω-type) is thought to be connected with Japanese armour, but it appeared and developed in the Korean peninsula in various forms, connecting methods, fixing holes and hole numbers before standardization. In the fifth stage, the burial of lamellar armour – B-type, D-type and E-type – increased in the Hapcheon area. This can be taken to reflect the strengthening of armoury by Dae-Gaya following the formation of Later Gaya. I have classified lamellar armour and have examined its regional distribution. I wanted to examine change in general aspect, form, and regional distribution since a synthesis of the lamellar armour of the Youngnam area in the 4~5th century has yet to be carried out. However,some of the data remained u...

대학 행정서비스 만족도 제고를 위한 수요자 관점의 품질 개선 요인에 관한 연구

황수진,현승용 한국생산관리학회 2015 한국생산관리학회 학술대회 논문집 Vol.2015 No.-

‘바이오레인(BIOREIN)’ - 실험동물자원 개발을 위한 식품의약품안전처의 구상 -

황수진,김진호,신희정,조영민,김해든,최경민,유동훈,정면우 한국에프디시규제과학회(구 한국에프디시법제학회) 2015 FDC법제연구 Vol.10 No.1

대학 행정서비스 개선을 위한 행정직원 서비스 실패와 회복에 관한 연구 – 수요자 관점에서 -Ⅱ

황수진,현승용 한국생산관리학회 2015 한국생산관리학회 학술대회 논문집 Vol.2015 No.-

Moyamoya disease in a 3-year-old boy presenting with a focal motor seizure provoked by hyperventilation

황수진,김중헌,윤희망,염미선 대한소아응급의학회 2018 대한소아응급의학회지 Vol.5 No.1

A previously healthy, 3-year-old boy presented to the emergency department with an afebrile focal motor seizure. He was found crying and having a seizure 30 minutes earlier. During this seizure, he was jerking his head and right extremities. Subsequent magnetic resonance imaging showed acute infarction in the bilateral frontal lobes, chiefly in the left. After hospitalization, conventional angiography demonstrated bilateral stenosis of the distal internal carotid arteries with development of lenticulostriate collaterals, which confirmed the diagnosis of moyamoya disease. It is vital to recognize focal motor seizures and situations related to hyperventilation in children with a seizure, which imply a structural lesion and a provoked cerebral ischemia in preexisting moyamoya disease, respectively.

양방향 방송 환경 하에서의 개인화 시스템에 대한 연구

황수진,황철현,박용준 한국정보과학회 2004 데이타베이스 연구 Vol.20 No.2

방송과 관련된 디지털 기술과 통신 기술의 급격한 발전은 방송 산업의 다양화와 컨텐트의 수적 증가를 유도한 반면 시청자의 시청 환경을 고려하는 편의성과 최적 정보전달 기술의 발전은 더디게 진행되어왔다. 본 논문에서는 국내에서 최근 상용 서비스가 실시된 양방향 TV 환경에서 시청자의 행위, 선호도, 성향등을 분석하여 시청자에게 최적화된 방송 채널과 프로그램을 추천함으로써 시청의 편의성을 증대시키는 개인화 시스템을 제안하고 제안된 개인화 시스템이 양방향 방송 산업에 미치는 영향성 및 가치사슬 지원 범위를 측정 하도록 한다.