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Clofibrate 의 유도체가 토기의 혈소판 응집에 미치는 영향
홍충만(Choon Man Hong),장동덕(Dong Deuk Jang),신동환(Dong Hwan Shin),조재천(Jae Chon Cho),조명행(Myung Haeng Cho) 한국응용약물학회 1995 Biomolecules & Therapeutics(구 응용약물학회지) Vol.3 No.2
Several clofibrate congeners (bezafibrate, gemfibrozil and fenofibrate) were investigated the relationship between effects on the aggregation induced by aggregating agents (thrombin, arachidonic acid, ADP and collagen) and arachidonic acid metabolism in rabbit homogenized platelet. In platelet aggregation study, all drugs produced no significant inhibition (data not shown) in arachidonic acid and thrombin. Also platelet aggregation by ADP was not changed in bezafibrate and inhibited dose dependently in fenofibrate and gemfibrozil. Platelet aggregation by collagen was inhibited dose dependently and significantly (from p<0.5 to p<0.001) by gemfibrozil and fenofibrate at concentrations between 20 and 400 μM. In arachidonic acid metabolism study, synthesis of thromboxane B₂ was not changed in rabbit platelet membranes and that of prostaglandin E₂ and F_(2α) was slightly increased by all drugs. It was concluded that clofibrate congeners inhibited ADP and collagen induced rabbit platelet aggregation and inhibition of collagen induced aggregation was probably mediated through some mechanism (pathway) other than arachidonic acid metabolism, judging from arachidonic acid metabolites (thromboxane B₂, prostaglandin E₂ and F_(2α)) synthesis in rabbit homogenized platelet.
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