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이선미(Sun Mee Lee),조태순(Tai Soon Cho),심상호(Sang Ho Shim),박석기(Seok Ki Park),홍채영(Chai Young Hong),김성수(Sung Soo Kim),신대희(Dae Hee Shin),김용기(Yong Kee Kim),박대규(Dai Kyu Park) 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.3
General pharmacological properties of l-muscone, the major component of musk, were investigated in mice, rats and guinea pig. The administration of l-muscone (1, 10, 100 mg/kg, p.o.) in mice had no effects in general behaviors, and no influences on analgesic actions and normal body temperature. Muscle relaxant action, intestinal propulsion and gastric secretion were not observed even at the high dose of 100 mg/kg. l-Muscone (l, 10, 100 mg/kg, p.o.) given to conscious rats showed no effect on mean blood pressure and heart rate. It showed no direct effect at 2.4 x 10^(-3) mg/ml and 2.4 x 10^(-2) mg/ml in isolated uterus of rats and ileum of guinea pig, and also had no inhibition of contraction induced by oxytocin and histamine.