Fe-Cr-C 合金剛에 있어서 反復加熱冷却處理에 依한 炭化物의 球狀化에 미치는 高溫加工燒入의 影響 : Fe-Cr-C 합금강에 있어서 반복가열냉각처리에 의한 탄화물의 구상화에 미치는 고온가공소입의 영향

홍영준 釜山大學校 工科大學 1982 工科大學 硏究 報告 Vol.23 No.-

Serum Concentration of Lipoprotein ( a ) is Decreased in Patients with Liver Diseases

홍영준,이효석,김상인,김진규,송정한 한국지질학회 1992 韓國脂質學會誌 Vol.2 No.1

간섭형 광섬유 센서용 신호처리기 설계

홍영준,김도익,예윤해 慶熙大學校 레이저 工學硏究所 2002 레이저공학 Vol.13 No.-

We propose a singnal processor that demodulates the output from an interferometeric sensor at high seed. It is a modified version of the ADPT(Advanced Digital Phase Tracking) that was developed to measure the phase difference in the interferometer with high resolution. The implemented signal processor was turned out to have a speed of 44 mrad/㎲, which is good enough to measure the vibration or voice signal with the maximum phase shift of π/4 rad.

New Drug-Eluting Stents

홍영준,정명호 대한심장학회 2005 Korean Circulation Journal Vol.35 No.3

The introduction of drug-eluting stents (DES)are now used in a majority of intracoronary stenting procedures. As a result of the innumerable trial-and-eror endeavors, DESs have emerged as a potential solution for solving the problem of restenosis. DESs are coated stents capable of releasing single or multiple bioactive agents into the bloodstream and the surrounding tisues. The eficacy and safety of DESs might differ depending on the pharmacologic agents and stent delivery systems that are used. Recent research has focused on the various constituents of DESs, including the stent backbone, the materials used as drug-delivery vehicles, and the physicochemical properties of the pharma-acute and chronic inflammation in the vessel wal, along with the elaboration of cytokines and growth factors that induce multiple signaling pathways to activate smooth muscle cell migration and proliferation. Utilization of antiproliferative agents delivered locally via the drug-eluting stents has dramatically reduced the stent restenosis rate. The polymer-regulated delivery of both paclitaxel and sirolimus at the site of arterial injury has ben shown to reduce the clinical and angiographic restenosis rates after stent implantation in de novo new stent platforms are now under clinical or preclinical evaluation. In this review, we describe the main clinical trials on DESs and the most recent information that has been derived from observational studies and registries. Moreover, the preliminary results on the new DESs are also summarized.

Relation Between High-Sensitivity C-Reactive Protein and Coronary Plaque Components in Patients With Acute Coronary Syndrome: Virtual Histology-Intravascular Ultrasound Analysis

홍영준,정명호,조석희,황승환,고점숙,이민구,박근호,심두선,윤남식,윤현주,김계훈,박형욱,김주한,안영근,조정관,박종춘,강정채,최윤하 대한심장학회 2011 Korean Circulation Journal Vol.41 No.8

Background and Objectives: We used virtual histology-intravascular ultrasound (VH-IVUS) to evaluate the relationship be-tween high-sensitivity C-reactive protein (hs-CRP) levels and plaque components in 279 acute coronary syndrome (ACS) pa-tients. Subjects and Methods: We divided patients into three groups according to their hs-CRP levels {lowest tertile <0.07 mg/dL (n=93), middle tertile ≥0.07, <0.4 mg/dL (n=93), and highest tertile ≥0.4 mg/dL (n=93)}. Thin-cap fibroatheroma (TCFA) was defined as focal, necrotic core (NC)-rich (≥10% of the cross-sectional area) plaques in contact with the lumen in a plaque burden ≥40%. Results: The highest tertile group was mostly diabetics (20%, 27%, 40%, p=0.009), and had the greatest plaque plus media volume (163±139/mm3 vs. 201±155/mm3 vs. 232±176/mm3, p=0.013). The highest tertile group had the greatest absolute and % NC volumes (13.6±15.1 mm3 vs. 14.8±14.2 mm3 vs. 23.7±24.3 mm3, p<0.001, and 14.9±8.7% vs. 16.0±8.7% vs. 19.5±10.2%, p=0.024, respectively). The culprit lesion TCFA was observed most frequently in the highest ter-tile group (28% vs. 35% vs. 55%, p=0.006). By multivariable analysis, absolute NC volume was an independent predictor of hs-CRP elevation {odds ratio (OR); 1.03, 95% confidence interval (CI)=1.06-1.21, p=0.004}, and hs-CRP was an independent pre-dictor of TCFA (OR; 1.86, 95% CI=1.11-2.90, p=0.010). Conclusion: VH-IVUS analysis has demonstrated that ACS patients with elevated hs-CRP have more vulnerable plaque component (NC-rich plaques and higher frequency of culprit lesion TCFA), compared with ACS patients with normal hs-CRP.

Abciximab(ReoPro)부착 관상동맥 스텐트의 세포외 기질 및 고사에 대한 영향

홍영준,정명호,안영근,임상엽,홍서나,이상현,김계훈,윤경호,강동구,이연상,박형욱,김주한,조정관,박종태,박창수,박종춘,강정채 대한심장학회 2005 Korean Circulation Journal Vol.35 No.4

Background and Objectives:The most important mechanism of coronary stent restenosis is neointimal hy-perplasia (NIH). In addition to neointimal cell proliferation, synthesis of the extracellular matrix (ECM) may be important for the induction of NIH. The efects of the abciximab (ReoPro)-coated stent on the ECM synthesis and cellular apoptosis in coronary stent restenosis were observed. Materials and Methods:Twenty one abcixi-mab-coated stents and 21 control stents were placed in porcine coronary arteries and histopathologic analyses were performed at 14 days, 28 days and 56 days after the stenting procedures, respectively. Each specimen was analyzed by hematoxylin and eosin staining, modified Movat, immunohistochemical staining and TUNEL analysis. Results:The area of neointima in the abciximab-coated stents was reduced by 45.7% and 45.5% of the control stents at 28 days and 56 days after stenting, respectively (1.9± 0.5 vs. 3.5± 0.7 mm2, 2.4± 0.5 vs. 4.4± 0.6 mm2, p= 0.012, 0.001, respectively). The content ratio of the proteoglycan of the abciximab-coated stents was reduced by 23% at 14 days (12.4± 4.4 vs. 16.1± 4.3%, respectively, p= 0.041)collagen in the abciximab-coated stents was reduced by 19.7% and 25% at 28 days and 56 days, respectively (27.7± 5.0 vs. 34.5± 8.7%, 36.6± 10.5 vs. 48.8± 12.7%, p= 0.021, 0.001, respectively). The proliferating cell nuclear antigen index of neointima for the abciximab-coated stents was reduced by 22.2% at 14 days (10.5± 5.4 vs. 13.5± 8.4%, respectively, p= 0.022)by TUNEL analysis between the two groups on the 56-day follow-up after stenting. Conclusion:The Abciximab-coated stent inhibits ECM synthesis, but it does not inhibit apoptosis in a porcine stent restenosis model. 배경 및 목적: 돼지 관상동맥에 혈소판 당단백 IIb/IIIa 수용체 차단제인 abciximab 부착 스텐트(ReoPro??-coated stent)와 대조 스텐트를 시술 후 시간경과에 따른 세포 증식률 및 세포외 기질의 분포와 스텐트 재협착의 형성과의 관계를 알아보고자 하였다. 방 법: 돼지 관상동맥 재협착 모형을 이용하며 abciximab 부착 스텐트 21개와 대조 스텐트 21개를 삽입하여 14일, 28일,56일째에 희생시켜 조직학적인 비교를 실시하였다. 혈관은 파라핀 포매괴를 만들고 박절편에서 Hematoxylin and Eosin 염색을 실시하고 세포외기질 성분에 대해 Masson Trichrome 염색을 실시하여 리오프로 부착 스텐트의 시간경과에 따른 세포외기질에 대한 영향을 분석하였고, proliferating cell nuclear antigen(PCNA)과 평활근 α-actin에대한 단클론 항체를 이용한 면역 조직 화학 염색법을 이용하여 리오프로 부착 스텐트가 세포증식 및 혈관 평활근 세포 증식에 미치는 영향을 조사하였으며 세포 고사에 대해서는 TUNEL 분석을 실시하였고 분석에는 Visus 2000 Visual Image Analysis system을 이용하였다. 결 과: 관상동맥 혈관 세포 손상 지수는 양 군에서 차이가 없었고 신생내막의 영역은 abciximab 스텐트 군에서 대조 스텐트 군에 비해 28일째 45.7%, 56일째 45.5% 각각 감소하였고(1.9±0.5 vs. 3.5±0.7, 2.4±0.5 vs. 4.4±0.6 mm2, 각각 p=0.012, 0.001), 내강 협착률은 abciximab 스텐트 군에서 대조 스텐트 군에 비해 28일째 48%, 56일째 48.1% 감소하였다(21.8±6.2 vs. 42.1±13.2, 28.2±10.4 vs. 54.3±18.4%, 각각 p=0.001, 0.001). 신생내막 내 proteoglycan의 비율은 abciximab 스텐트 군에서 대조 스텐트 군에 비해 14일째 23% 감소하였고(12.4±4.4 vs. 16.1±4.3%, p=0.041), 신생내막 내 collagen의 비율은 abciximab 스텐트군에서 대조 스텐트 군에 비해 28일째 19.7%, 56일째 25% 감소하였다(27.7±5.0 vs. 34.5±8.7, 36.6±10.5 vs. 48.8±12.7%, 각각 p=0.021, 0.001). PCNA 양성 세포의 비율은 abciximab 스텐트 군에서 대조 스텐트 군에 비해 14일째 22.2% 감소하였다(10.5±5.4 vs. 13.5±8.4%, p=0.022).신생내막 내 세포들에서 평활근 α-actin 양성을 나타내었고 이는 스텐트 삽입 후 주수에 따라 증가하였으며 abciximab 스텐트 군에서 대조 스텐트 군에 비해 낮은 경향을 보였다. 신생내막 내 고사 세포의 비율은 14일, 28일, 56일째에 abciximab 스텐트 군이 각각 25.9±10.1, 34.2±12.9, 44.4±17.3%, 대조 스텐트 군이 각각 22.5±11.0, 30.6±13.2, 40.2±19.8%로서 세포고사에 있어서 양군 간에 유의한 차이는 없었다. 결 론: Abciximab(ReoPro??) 부착 스텐트는 세포 증식과 세포외기질형성을 억제하였으나 세포 고사에는 영향이 없었다.

언택트 시대, 공공복지서비스의 지역적 한계와 과제: 서울사례를 중심으로

홍영준 한국지역사회복지학회 2020 한국지역사회복지학회 학술대회 Vol.2020 No.11

Predictors of Plaque Progression in Hypertensive Angina Patients with Achieved Low-Density Lipoprotein Cholesterol Less Than 70 mg/dL after Rosuvastatin Treatment

홍영준,박근호,박종춘,조정관,안영근,정명호,김주한,심두선,김민철,김현국,김우진 전남대학교 의과학연구소 2015 전남의대학술지 Vol.51 No.3

We evaluated the impact of achieved low-density lipoprotein cholesterol (LDL-C) concentrations<70 mg/dL on plaque progression in statin-treated hypertensive anginapatients by use of virtual histology-intravascular ultrasound (VH-IVUS). The effectsof 10 mg of rosuvastatin on plaque progression were evaluated in 78 patients who achievedLDL-C <70 mg/dL with statin treatment. The patients were divided into plaqueprogressors (n=30) and plaque regressors (n=40) on the basis of the baseline minimumlumen area (MLA) site at the 9-month follow-up. The prevalence of chronic kidney disease(CKD) [creatinine clearance (CrCl) <60 mL/min)] and current smoking was higherin progressors than in regressors (90.0% vs. 31.3%, p<0.001, and 40.0% vs. 12.5%,p=0.005, respectively). Baseline CrCl was significantly lower and baseline apolipoprotein(apo) B/A1 was significantly higher in progressors than in regressors (21±13mL/min vs. 70±20 mL/min, p<0.001, and 0.77±0.23 vs. 0.65±0.16, p=0.011, respectively). Absolute and relative fibrotic areas at the MLA site increased in progressors;by contrast, these areas decreased in regressors from baseline to follow-up. CKD [odds ratio (OR): 2.13, 95% confidence interval (CI): 1.77-2.53, p=0.013], smoking(OR: 1.76, 95% CI: 1.23-2.22, p=0.038), and apoB/A1 (OR: 1.25, 95% CI: 1.12-1.40,p=0.023), but not any VH-IVUS parameters, were independent predictors of plaqueprogression at follow-up. In conclusion, clinical factors including CKD, smoking, andapoB/A1 rather than plaque components detected by VH-IVUS are associated with plaqueprogression in hypertensive angina patients who achieve very low LDL-C after statintreatment.

배드민턴 선수가 인식하는 지도자의 자율성지지와 운동탈진의 관계에서 운동정서의 매개효과

홍영준,최유리 한국스포츠학회 2022 한국스포츠학회지 Vol.20 No.3

The purpose of this study was to investigate the parallel multi-mediating effect of Athletic Emotions on the Relationship between Leader's Autonomy Support and Exercise Exhaustion in Badminton Players. In order to achieve the purpose of the study, the data of 255 badminton players registered as players in the Korean Sports Council in 2022. The collected data were analyzed through descriptive statistics, reliability test, exploratory factor analysis, correlation analysis, and model 4 of the PROCESS macro (v.3.3) using the SPSS 23.0 program, and the results are as follows. First, positive emotion, was found to mediate the relationship between autonomy support and emotional/physical exhaustion. Second, both positive and negative emotions, were found to mediate the relationship between autonomy support and exhaustion of a sense of achievement. Third, positive emotion, was found to mediate the relationship between autonomy support and devaluation. It was found that the coach's support for autonomy perceived by the players mediates athletic emotion and reduces exercise exhaustion. In addition, positive emotions experienced by athletes decreased exercise exhaustion, and negative emotions increased exercise exhaustion, indicating that exercise emotion and exercise burnout are closely related. To summarize the results of the study, it is effective for the coach to maintain a positive emotion by autonomy supporting the of the athletes in order to reduce the athletes' exhaustion. 본 연구는 배드민턴 선수가 인식하는 지도자의 자율성지지와 운동탈진의 관계에서 운동정서의 병렬다중매개효과를 알아보는데 목적이 있었다. 연구의 목적을 달성하기 위하여 2022년 대한체육회에 선수로 등록되어 있는 배드민턴 선수 255명의 자료를 수집하였다. 수집된 자료는 SPSS 23.0 프로그램을 활용하여 기술통계, 신뢰도 검사, 탐색적 요인분석, 상관관계 분석과 PROCESS macro(v.3.3)의 모델 4를 통해 분석을 실시하였으며, 그 결과는 다음과 같다. 첫째, 운동정서의 하위요인 긍정정서는 자율성지지와 정서/신체 소진의 관계를 매개하는 것으로 나타났다. 둘째, 운동정서의 하위요인 긍정정서와 부정정서 모두 자율성지지와 성취감 소진의 관계를 매개하는 것으로 나타났다. 셋째, 운동정서의 하위요인 긍정정서는 자율성지지와 평가저하의 관계를 매개하는 것으로 나타났다. 선수들이 인식하는 지도자의 자율성지지는 운동정서를 매개하여 운동탈진을 감소시키는 것으로 나타났다. 또한, 선수가 경험하는 긍정정서는 운동탈진을 감소시키고, 부정정서는 운동탈진을 높이는 것으로 나타나 운동정서와 운동탈진은 밀접한 관련이 있는 것으로 나타났다. 연구결과를 종합해보면, 선수들의 운동탈진을 감소시키기 위해서는 지도자는 선수들에게 자율성을 지지하여 긍정정서를 유지하는 것이 효과적이다.

유럽의 영상산업과 마케팅환경

홍영준 호남대학교 인문사회과학연구소 1998 인문사회과학연구 Vol.5 No.-