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Implication of Egr-1 in trifluoperazine-induced growth inhibition in human U87MG glioma cells
신순영,김장근,홍동대,김정혜,이영한 생화학분자생물학회 2004 Experimental and molecular medicine Vol.36 No.4
The early growth response gene-1 (Egr-1) is a tumor suppressor which plays an important role in cel growth, diferentiation and apoptosis. Egr-1 has been shown to be down-regulated in many types of tumor tisues. Trifluoperazine (TFP), a phenothiazine class of antipsychotics, restored se-rum-induced Egr-1 expression in several cancer cell lines. We investigated the effect of Egr-1 expression on the TFP-induced inhibition of cell growth. Ectopic expression of Egr-1 enhanced the TFP-induced antiproliferative activity and down-regulated cyclin D1 level in U87MG glioma cells. Our results sugest that antipsychotics TFP exhi-bits antiproliferative activity through up-regulation of Egr-1.