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생약복합제제의 약효연구 (제6보) : 생간건비탕의 혈청중 효소활성도, 성분함량 및 이담효과에 대한 작용
홍남두(N. D. Hong),김종우(J. W. Kim),김병운(B. W. Kim),손정곤(J. G. Shon) 한국생약학회 1982 생약학회지 Vol.13 No.1
In order to investigate the pharmacological action of the combined preparation of crude drugs, Saengkankunbi-Tang were studied. These studies were conducted in an attempt to investigate the effect of Saengkankunbi-Tang on activities of the liver enzyme, protein contents and the excretory action of bile juice in the serum of CCl₄-intoxicated rabbits. The results of this investigate were summerized as follows; GOT, GPT activities and total cholesterol contents in the serum of rabbits induced by CCl₄ were shown to the remarkable decrease with the passage of the time in the oral administration of the sample. Albumin contents in the serum of rabbits induce by CCl₄ were noted to the significant increase with the passage of the time. Serum total protein contents were noted to the significant increase only the 4th and 6th day. BSP accumulation contents in the serum of rabbits induced by CCl₄ showed the remarkable decrease with the passage of the time.
생약복합제의 약효연구 (제5보) : 황연해독탕이 부종, 장관, 혈압, 혈당량, 총코레스테롤 함량 및 항균작용에 대하여
홍남두(N. D. Hong),김종우(J. W. Kim),두호경(H. K. Doo),김남재(N. J. Kim) 한국생약학회 1982 생약학회지 Vol.13 No.1
In order to investigate the effect of Whangryonhaedok-Tang on the anti-inflammatory, ileum of mice, blood pressure, blood glucose, total cholesterol and antibacterial activity, those pharmacological actions were conducted. The results of this studies were summerized as follows; Rat hind paw edema induced by acetic acid was inhibited. In mice, tone of intestinal smooth muscle was suppressed with the treatment of sample and intestinal contractions induced by BaCl₂ was inhibited. Hypertensive effect was not observed in rabbits but was observed by the water extract of Whangryonhaedok-Tang excluded Phellodendri Cortex in rabbits. The incleased blood glucose levels in alloxandiabetic rabbits were significantly decreased by the oral administration of the sample I after 6 days. The total cholesterol levels in alloxan-induced rabbits were significantly decreased by the oral administration of the sample I after 9 days. Antibacterial activity was observed. In addition, we thought the pharmacological actions were significantly noted by the sample III(Methanol soluble fraction) because of the purification of effective components.
생약복합제제의 품질관리에 관한 연구 (제1보) : 삼요탕에 대하여
홍남두(N. D. Hong),김종우(J. W. Kim),김남재(N. J. Kim),손정근(J. G. Shon) 한국생약학회 1982 생약학회지 Vol.13 No.1
합성의 약품의 부작용 및 공해로 인하여 천연물인 생약에서의 약품을 개발하려는 경향과 천연물화학의 발달로 유효성분 및 약리작용 등이 규명되어짐에 따라 생약복합제의 품질관리가 적실히 요망되고 있다. 현재 생약복합제제의 품질관리에 있어서는 특정성분을 표준물질로 대조품질관리하고 있어 다 성분, 다성질의 생약복합제의 품질관리로는 미흡하여 국민 보건 및 의약품 개발의 저해요소가 되어 있는 실정이다. 연차 등은 천연물의 특성을 고려 각종 기기를 이용하여 생약복합 제제의 품질관리법을 확립하고저 먼저 동의보감에 수록된 삼요탕에 대하여 T.L.C scanner에 의한 개개 생약의 profile pattern과 복합제의 pattern을 중심으로 분석한 바 품질관리가 가능할 것으로 사료되어 이를 보고하는 바이다.
생약 복합제제의 약효에 관한 연구 (제1보) : 가미 삼황탕(사심탕)의 순환기계 및 항균작용에 대하여
홍남두(N. D. Hong),김종우(J. W. Kim),송일병(I. B. Song),김남재(N. J. Kim) 한국생약학회 1982 생약학회지 Vol.13 No.1
한약제는 장구한 세월동안 인명의 희생, 치유 경험의 반복을 거쳐 집약된 것으로서 인류 보건에 크게 기여하여 온 전승의약이다. 한때 현대의약의 발달로 이를 비과학적이라 하여 소외시한 경향이 있었으나 현대의약품의 공해, 개발의 한계등으로 전승 약물에의 탐색경향과, 천연물화학의 발달로 약효성분의 단리, 화학구조식 결정, 약리작용의 기전 및 안전성 등이 점차 구명되어 짐에 따라 의약물로서의 평가를 받게되고 있다. 그러나 이들의 연구의 대부분이 생약단종을 대상으로 하고 있으며 생약복합계제에 대한 보문은 별로 찾아볼 수 없다. 연자등은 한방고서 및 임상에서 많이 쓰여지고 있는 생약복합제의 효능을 중심으로 하여 실험적으로 구명하고저 먼저 가미삼황탕(사심탕)을 선정하여 본 실험에 착수 하였다. 가미삼황탕(사심탕)은 금괴요약, 천금요방등에 수록되어 있으며 심병증이라 할 수 있는 심화, 심열을 다스리는 약으로서 정신신경병증, 발열병증, 등릉병증, 순환병증, 창양병증에 유효한 것으로 되어 있어 우선 중추 신경계에 대한 작용을 추구코저 각종 실험동물을 써서 관찰하여 약간의 결과를 얻었기에 보고한다.
생약 복합제제의 약효에 관한 연구 (제Ⅱ보) : 가미 삼황탕(사심탕)의 중추 신경계 작용에 대하여
홍남두(N. D. Hong),김종우(J. W. Kim),송일병(I. B. Song),김남재(N. J. Kim) 한국생약학회 1982 생약학회지 Vol.13 No.1
전보에서 제시한 바와 같이 가미삼황탕(사심탕에 대한 추구의 일환으로 순환기계 및 항균작용에 관한 실험결과를 얻었기에 보고드리는 바이다.
생약 복합제제의 약효연구 (제2보) : 가미삼황탕이 순환기계 및 항균작용에 대하여
홍남두(N. D. Hong),김종우(J. W. Kim),송일병(I. B. Song),김남재(N. J. Kim) 한국생약학회 1981 생약학회지 Vol.12 No.4
It was prevously shown that Kamisamhwang-Tang had been examined for effects of the anticonvulsion, antipyretic, analgesic and sedative. To investigate the effect on cardiovascular system and antibacterial activities, pharmacological studies have been carried out with each extract. The results of this investigation were summerized as follows: 1) Kamisamhwang-Tang depressed central convulsion induced by strychnine, picrotoxine and caffeine in mice. 2) Antipyretic, analgesic and sedative action were observed. 3) Hypotensive effect was observed in rabbits. 4) Antibacterial activities was observed.
생약복합제제의 약효연구(제3보) : 강심산의 기초약물학적 활성에 대하여
홍남두(N. D. Hong),김종우(J. W. Kim),정재혁(C. H. Cheong),최승기(S. G. Choi) 한국생약학회 1981 생약학회지 Vol.12 No.4
Kangsim-San is an added and subtracted prescription of Cheongsim-Yeonza-Tang recorded in Dongeuy-Soose-Boweon from which it has become one of the favorate prescriptions at the Oriental Medical Hospital, Kyung-Hee University. It is described in the book that the Cheongsim-Yeonza-Tang can be effective to symptoms relating to fatigue, nocturnal emission, abdominal pain, tongue deviation and palsy, etc. However the Kangsim-San has been used for neutotic syndrome, pulpitation, insomnia, constipation, dry-mouth, auorexia and arrythmias and so on, added to the above-mentioned symptoms for the Cheongsin-Yeonza-Tang at the hospital. Nevertheless, the pharmacological research of fundamental basis is not completed so far, and we have attempted experiment on various animals to study the pharmacological effects of the medicine. The result was proved as follows; The prescription had a considerable effects on the sedation of central nervous system, antipyretic and analgesic action, and vasodilative action.
생약복합제제의 품질관리에 관한 연구(제1보) : TLC Scanner에 의한 삼요탕의 품질관리
홍남두(N. D. Hong),김종우(J. W. Kim),김남재(N. J. Kim),손정곤(J. G. Shon) 한국생약학회 1981 생약학회지 Vol.12 No.3
In our country, in order to cure diseases, a large number of crude drug preparations has been available. Nevertheless, the development of crude drug preparations have been inhibited, because the quality control is not completed so far. Therefore, we have eontinued on studing the quality control method by Zig-zag TLC. profile analysis. The water extract of Samyo-Tang and componental crude drug (Glycyrrhizae Radix, Ephedrae Herba, Armenicae Semen) were developed on Silica gel 60F_(254) plate (E. Merck) useing elution solvent. The developed plate were examined useing Dual Wavelength Zig-zag Scanner (Shimadzu). According to the results of the experiment, it could be summerized as follow: 1) Original patterns of TLC profiles of Samyo-Tang componental crude drug and mixing two crude drugs of Samyo-Tang were observed. 2) Original patterns TLC profile of each extract after spraying with 2% ninhydrine were observed. 3) In the extract of addition and subtraction of Ephedrae Herba, peak area of Rf 0.48 and Rf 0.60 were varied quantitatively.
생약복합제의 약효 연구 (제1보) : 가미삼황탕이 중추신경계에 미치는 영향
홍남두(N. D. Hong),김종우(J. W. Kim),송일병(I. B. Song),김남재(N. J. Kim) 한국생약학회 1981 생약학회지 Vol.12 No.3
In order to investigate the efficacy of combined preparations of crude drug, first, Kamisamhwang-Tang were examined for pharmacological effect. Crude drug preparations were extracted successively with H₂O and MeOH, and the extracts were developed on silicagel G plate were examined using the Dual-Wavelength TLC Scanner CS-910 (Schimadzu) in ultra violet region. To estimate the clinical usefulness of Kamisamhwang-Tang in heart disease (Symbyung syndrome), the above extracts were made an experiment on effects of the anticonvulsion, antipyretic, analgesic and sedative in mice, rats, and rabbits.