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오리나무 추출물(AI-1367)의 간질환 동물모델에서의 간 보호효과
조우철(Yu-Zhe Zhao),이성희(Sung Hee Lee),허재욱(Jae-Wook Huh),라정찬(Jeong Chan Ra),손동환(Dong Hwan Sohn) 대한약학회 2012 약학회지 Vol.56 No.2
The protective effect of AI-1367 (Alnus japonica extract) on liver injury was investigated. Primary rat hepatocyte intoxication was induced by tert-butyl hydroperoxide (tBH), carbon tetrachloride (CCl4), or D-glactosamine (D-GalN). Liver injury was induced by CCl4, D-GalN or MCD (methionine choline deficient)-diet in mouse. The cellular leakage of lactate dehyrogenase and cell viability followed by the treatment of hepatotoxicants were significantly improved by AI-1367 treatment at a concentration range of 5~50 μg/ml for tBH, 5~50 μg/ml for D-GalN, and 5~100 μg/ml for CCl4, respectively. Treatment with AI-1367 (20, 10, 5 mg/kg, p.o.) on liver injury induced by subcutaneous injection of CCl4 or D-GalN reduced significantly the levels of aspartate transaminase and alanine transaminase in serum. Histological observations revealed that fatty acid changes, hepatocyte necrosis and inflammatory cell infiltration in CCl4 (D-GalN)-induced liver injury was improved by administration of AI-1367. AI-1367 treatment (10, 5, 2.5 mg/kg, p.o.) also significantly recovered the body weight change and serum levels of aspartate transaminase, alanine transaminase and triglyceride in liver injury induced by MCD diet. From these results, AI-1367 shows protective effects against tBH, CCl4, D-GalN, or MCD diet-induced hepatotoxicity in vitro or in vivo.
유전자 재조합 사람형 erythropoietin, GC-rhEPO의 약물동태 및 조직분포
김선돈 ( Sun Don Kim ),한성규 ( Seong Kyu Han ),이호성 ( Ho Sung Lee ),김성남 ( Seong Nam Kim ),정원휘 ( Wo Nee Chong ),백대현 ( Dae Hyun Baek ),조은성 ( Eun Sung Cho ),허재욱 ( Jae Wook Huh ),류판동 ( Pan Dong Ryu ) 한국응용약물학회 2000 Biomolecules & Therapeutics(구 응용약물학회지) Vol.8 No.2
단세포 나팔벌레,Stentor coeruleus의 빛에 의한 ATP 합성
Chen, B.H.,허재욱,민태진,Iwatsuki, K,송필순 동국대학교 자연과학연구소 1986 자연과학연구 논문집 Vol.6 No.-
나팔벌레의 세포내 ATP 함량은 0.5~2초동안 40W/m₂백색광을 조사함에 따라 어두운 상태의 대조구에 비하여 급격히 증가하였고, 빛을 계속하여 조사하면 세포내 ATP 함량은 단계적으로 감소하였다. 광수용체 색소 Stentorin 을 포함하고 있는 색소 미립자를 나팔벌레 완전세포로부터 분리하여 이에 ADP와 pi를 가한 혼합물에 빛을 조사하여 ATP가 생성됨을 확인하였다. 나팔벌레 완전세포와 색소미립자주으이 ATP 함량은 변량울에 (fluence rate)의존하였다. 이들 결과로 생명체는 광양자를 ATP로 전이시킬 수 있고, ATP 생성은 나팔벌레 색소미립자의 특성으로 사려된다. The cellular ATP level in Stentor coeruleus jumped above the dark control level when stimulated by 0.5-2 second light pulses (40W/m₂white light). Continued, irradiation fo the cells caused a gradual decline of the cellular ATP level. Pigment granules containing the photoreceptor pigment stentorin isolated from whole cells also exhibited a light-induced ATP synthesis. The ATP level in both whole cells and pigment granules was dependent upon the fluence rate. These results suggest that the organism is capable of tranducing light quanta into ATP and that ATP synthesis is localized in the pigment granule.