http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 허인회(In Hoi Hur) (검색결과 1 건)
- 무료
- 기관 내 무료
- 유료
-
사염화탄소 및 에탄올에 의해 유도된 만성간 손상에 미치는 말로틸레이트의 항산화 작용
김형춘(Hyoung Chun Kim),허인회(In Hoi Hur) 대한약학회 1990 약학회지 Vol.34 No.4
To achieve a better understanding of antioxidant action manifested by malotilate, the dithiol malonates, we monitored the oxy radical-scavenging system against the chronic hepatic damage induced by CCl4 alone or in combination with ethanol. Malotilate was given orally at a dose of 100mg/kg/day and CCl4 1.5ml/kg was injected subcutaneously twice a week for 4 weeks. In each group receiving ethanol, drinking water was replaced by 20% aqueous solution or glucose, isocaloric amounts of ethanol, as a control of ethanol was diluted in its drinking water. Each rat was killed as a starved state at 18 hours after the period of the experiment, four weeks. The results were summarized as follows: 1)Malotilate inhibited the rate of generation of superoxide radicals, the accumulation of lipoperoxides, and promoted the synthesis of glutathione in the liver. 2)Malotilate stimulated the enhancement of activity of superoxide dismutase in hepatic mitochondria. 3)Malotilate had no effects on the hepatic H202 contents. 4)Malotilate showed the increase of catalase activity in the liver poisoned with CCl4, and also gave a tendency to increase it in the liver intoxicated with ethanol. Thus, our data suggested that the activation of hepatic antioxidant system in the presence of malotilate would play a role in protecting liver against the toxic effects of oxy radical and/or lipid peroxides under the hepatotoxic conditions induced by CCl4 with or without ethanol. However, the effects of malotilate against the ethanol-induced hepatotoxicity appear to be insignificant.
ScienceON
스콜라연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
