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허민규(M. K. Her),김동식(D. S. Kim),서영주(Y. J. Seo) 한국소성가공학회 2012 한국소성가공학회 학술대회 논문집 Vol.2012 No.10
Today’s automotive lamp trend is more large, eco-friendly and intelligent. And lighting source is changing Halogen and Xenon to LED. LED automotive lamp is composed LED lighting source, reflector, and aspheric lens that is made from glass. But the lens made from glass is limited to make various designable goods. So development of lens made from polymer is required. This study is development LED lens with polymer that is more design freedom and lighter than glass.
수시 학생부 교과전형에서의 수능최저등급 완화 방안에 대한 연구
홍정의,허민규 한국교통대학교 2015 한국교통대학교 논문집 Vol.50 No.-
The goal of this study is analyze the relationship between student high school grade and university academic achievement also Scholastic Ability Test score and university academic achievement. Department of Education continuously asked reduce the types of admission and mitigate admission restriction. For the purpose of simplify university admission process, we need to mitigate or remove the minimum standard of SAT score. At this research, analyzed the effects of mitigating minimum SAT score and suggested possible solution
유방암 세포주에 에스트로겐 및 항에스트로겐 처치에 따른 coregulators, MAP kinase 활성도 및 세포주기 조절인자 p27/kip1의 변화
박세호,허민규,이미정,김주희,박병우 한국유방암학회 2008 Journal of breast cancer Vol.11 No.2
Purpose: Estrogen, various polypeptide hormones and growth factors are associated with the development and progression of breast cancer. Coregulatory proteins are also associated with estrogen receptor (ER) transcriptional activity and tamoxifen resistance. Therefore, it is necessary to investigate the change of coregulator mRNAs and various cell proliferation proteins and cell cycle-related proteins after treatment with estrogen or antiestrogen. Methods: MCF-7 cells were maintained in dextran-coated charcoal stripped 10% Dulbecco's Modified Eagle Medium (DMEM). To measure the change of the coactivators’ (src-1, P/CAF, CBP, AIB1) mRNAs and corepressors’ (SMRT, N-coR) mRNAs, multiple PCR was carried out using specific primers. In addition, intracellular proteins related to cell proliferation and cell cycle regulation were measured by performing Western blotting after treatment with estrogen or tamoxifen. The change of mitogen activated protein kinases was also measured by performing Western after tamoxifen treatment for 4 weeks. Results: Coactivator mRNAs expression rapidly decreased in 15 minutes after estrogen treatment but this recovered to the initial level in 3 hours. The pattern was similar for the case of tamoxifen treatment. Corepressor mRNAs expression rapidly decreased in 15 minutes after estrogen treatment and it remained at a lower level until 24 hours after estrogen treatment. With tamoxifen treatment, the initial response was similar to the cases of estrogen treatment, but the expression gradually increased 3 hours after tamoxifen treatment. Treatment of estrogen induced intracellular concentrations of c-myc and Ki-67 and it increased nuclear translocation of NF-kB and phosphor-ERK and it decreased the intracellular cell cycle suppressor p27/kip1. Tamoxifen treatment increased nuclear p27/kip1 but it decreased c-myc, NF-kB and phosphor-ERK. Long-term (4 weeks) treatment of tamoxifen was associated with decrease of activated ERK and p38 but there was no change in phospho-Akt level. Conclusion: Estrogen induced cell proliferation and the survival pathway-related factors, but it decreased the cell cycle suppressor p27/kip1. Long-term treatment with antiestrogen tamoxifen might decrease the MAPK activities in ERα-expressing tumor cells.
흰쥐 암컷에서 시상하부 PACAP에 의한 프로락틴 유전자 발현의 조절
김영일,하태영,김은숙,남궁일성,MS O'Dorisio,허민규,박상규 대한내분비학회 2004 Endocrinology and metabolism Vol.19 No.2
Background: Pituitary adenylate cyclase-activating polypeptide(PACAP) plays the role of a hypophysiotropic factor, which regulates the synthesis and secretion of pituitary hormones through the hypothalamo-hypophysial portal system. No clear evidence has yet been reported regarding the regulation of prolactin(PRL) by PACAP. In the present study, we tested a hypothesis that PACAP regulates the synthetic machinery of PRL during the estrus cycle and pubertal process using intracerebroventricular(i.c.v.) injection of an antisense oligodeoxynucleotide(ODN) against type I PACAP receptor(PAC1).Methods: An RNase protection assay(RPA) was used to determine the pattern of hypothalamic PACAP and PAC1 mRNA expressions during the estrus cycle. Antisense PAC1 ODN was administered via i.c.v. injection to the female rats in normal estrus cycle of pubertal process. Northern blot analysis was used to determine the mRNA ievel of PRL in the pituitary gland Results: 1) PACAP mRNA in the medial basal hypothalamuswas significantly increased at the diestrus I, while PAC1 mRNA showed no significant change. 2) PRL mRNA level of pituitary was increased by an injection of antisense PAC1 ODN at the proestrus and estrus stages. 3) PRL mRNA level of pituitary was significantly decreased by antisense PAC1 ODN injection at stage of prepuberty and initiate puberty, while its level was increased at stage of puberty. Conclusion: These data suggest that PACAP suppresses PRL mRNA synthesis through the PAC1 signaling pathway in the certain estrus cycle environments. It may be also involved in the regulation of pituitary PRL gene expression during the pubertal process.
가상현실을 이용한 호흡근 훈련의 집중력 변화가 흡연자의 폐 기능에 미치는 효과
배세현,안현,양희성,김수진,김예림,최예령,이세연,허민규,김경윤 대한심장호흡물리치료학회 2024 대한심장호흡물리치료학회지 Vol.12 No.1
Purpose: This study aimed to investigate the effect of changes in concentration through respiratory muscle training using virtual reality on training concentration and pulmonary function in male smokers who have decreased concentration because of academics, employment, and smoking. Methods: The study included 15 male university students who had smoked for >2 years. They were randomly allocated to the control group (n=8) that performed respiratory muscle training using breathing exercise equipment and experimental group (n=7) that performed respiratory muscle training using virtual reality. The training was performed three times a day, three times a week, for a total of 4 weeks. During training, concentration was measured considering changes in the RAHB and heart rate variability (low frequency to high frequency [LF/HF] ratio) using QEEG-32FX, and pulmonary functions were measured based on changes in forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and FEV1/FVC using Spiropalm. Results: After the intervention, the experimental group showed significant improvement in the LF/HF ratio (p <.01), FVC (p<.05), and FEV1(p<.05), whereas the control group showed significant improvement in the LF/HF ratio (p<.05) and FVC(p<.05). Conclusion: The result of this study revealed that respiratory muscle training using virtual reality is more effective in improving pulmonary function by further enhancing training concentration.