경피적 관상동맥중재술 후 재협착 예방에 대한 한약의 효과 : 무작위배정 대조군 임상연구에 대한 체계적 문헌고찰 및 메타분석

허나연,안수빈,김홍준,장인수,Nayeon Hur,Subin Ahn,Hongjun Kim,Insoo Jang 대한한방내과학회 2023 大韓韓方內科學會誌 Vol.44 No.3

Objective: This study was conducted to investigate the preventive effect of herbal medicines on restenosis after percutaneous coronary intervention (PCI) by reviewing randomized controlled trials (RCTs). Methods: RCTs were searched for herbal medicine treatment after PCI using eight online databases (PubMed, CNKI, Wanfang, J-STAGE, OASIS, ScienceON, KTKP, and KISS). Studies that confirmed restenosis through coronary angiography at follow-up were selected according to the inclusion and exclusion criteria. The primary outcome was the restenosis rate, and the secondary outcome was the angina recurrence rate. Data were extracted from the final selected studies according to the research methodology and then analyzed with Review Manager 5.4.1. Study quality was assessed using Cochrane's risk-of-bias (RoB) tool. Results: Of the 252 papers obtained through the primary search, nine studies that met the selection criteria were finally selected. In these nine studies, herbal medicine combined with western medicine was used for the experimental group, and western medicine treatment was used alone for the control group. The meta-analysis result revealed that the restenosis rate and angina recurrence rate were significantly lower in the experimental group than in the control group (RR=0.34, 95% CI: 0.22-0.53, p<0.00001, I²=0% and RR=0.47, 95% CI: 0.29-0.78, p=0.004, I²=0%, respectively). Furthermore, the quality of studies assessed by Cochrane's RoB was low. Conclusions: This study showed that the combined treatment of herbal medicine and western medicine was effective in preventing restenosis and angina after PCI. As the number of papers included in this study was small, a large number of high-quality clinical studies should be considered in the future.

조기 덤핑증후군 환자의 복통에 감초분밀탕을 사용한 1례

최은석,허나연,김연주,정혜인,홍승원,장인수 대한한방내과학회 2022 大韓韓方內科學會誌 Vol.43 No.5

The purpose of this study is to explore the effectiveness of Gamchobunmil-tang as a treatment for early dumping syndrome. A patient reported abdominal pain after eating, was not able to eat more than two spoons of thin rice gruel, and had lost 8 kg of his weight. The patient was treated with Gamchobunmil-tang three times a day for 12 days. The effects of the treatment were evaluated using the Visual Analogue Scale and the amount and form of the patient’s intake. After treatment, the pain due to the dumping syndrome decreased. The Visual Analogue Scale score dropped significantly from 9 to 2, and increased amounts and novel forms of the food the patient consumed were observed. Despite the lack of a case, the results showed that Gamchobunmil-tang was effective in reducing the pain caused by the early dumping syndrome. Further research might prove that Gamchobunmil-tang could be an alternative treatment method for early dumping syndrome.

집속초음파 치료의 한의 임상 활용에 대한 고찰

최유민,이마음,허나연,이은희,최혁용,서형식,황의형,장인수 경락경혈학회 2023 Korean Journal of Acupuncture Vol.40 No.3

Objectives : The purpose of this study is to investigate various application methods of focused ultrasound and apply them to clinical use in Korean medicine. Methods : Search was performed using the search engines of electronic databases, including PubMed, ScienceDirect, Cumulative Index to Nursing and Allied Health Literature (CINAHL), ScienceON, Oriental Medicine Advanced Searching Integrated System (OASIS), China National Knowledge Infrastructure (CNKI), Wanfang Data, Japan Science Technology Information Aggregator, Electronic (J-STAGE) and Citation Information by NII (CiNii), from inception to July 2023 without language limitation. Inclusion criteria were clinical studies including randomized controlled trials (RCTs), and animal experimental studies related with focused ultrasound treatments for acupoints or meridian sinews. Results : Total 17 papers, 7 for RCT, 6 for in vivo animal studies, and other experimental studies, were finally selected. Indications used in studies were shoulder pain, back pain, chronic back pain, and degenerative knee arthritis. In experimental studies, studies on animal models of hypoxic ischemic brain damage and hyperlipidemia were also conducted. As for the acupoints, LR3, LI4, and ST36 were used in clinical studies and, in animal experimental studies, GV20, KI1, and ST36 were used. As for the dose, 4 studies below 3 W/cm2 and 3 studies in the range of 0.625 to 5 W/cm2 in clinical studies, and all studies did not exceed 5 W/cm2. In animal experimental studies, 0.5 W/cm2, 2 W/cm2, 7.5 WW/cm2, 15 W/cm2, 10∼20 W/cm2 were used. In all three studies describing the penetration depth during irradiation, it was less than 1 cm. Conclusions : We suggest that focused ultrasound is an appropriate treatment tool for stimulating the acupoints to transfer heat energy. Future studies with rigorous and well-designed RCTs for various diseases will be required to ascertain the focused ultrasound stimulate acupoints or meridian sinews.

누크관 수종 제거 이후 후유증에 대한 한방치료 1례 : 증례보고

안수빈,염지윤,허나연,강세영 대한한방내과학회 2023 大韓韓方內科學會誌 Vol.44 No.5

Objective: The purpose of this case study is to report the hydrocele of the canal of Nuck and the effectiveness of Korean medicine in post-surgery improvement of symptoms. Method: A patient who was diagnosed with hydrocele of the Nuck canal and had symptoms after Lichtenstein’s operation was treated using Korean medicine, including acupuncture, herbal medicine, and moxibustion, every day. The evaluation was performed using the Numeral Rating Scale (NRS), the 5-level EQ-5D version (EQ-5D-5L), the EQ visual analogue scale (EQ-VAS), and the World Health Organization Quality of Life-Brief (WHOQOL-BREF). Results: After treatment, changes were observed in NRS (from 8 to 2-3) and EQ-VAS (from 60 to 85), whereas there was no difference in EQ-5D-5L (both 6). There was an overall improvement in the domains of WHOQOL-BREF and subjective symptoms. Conclusion: This study suggests that Korean medicine may improve symptoms after surgery of hydrocele of the canal of Nuck and can be evaluated using an overall QoL questionnaire.

채색안료 분석에서 ED-XRF(ELIO)의 적용 연구

장준영 ( Junyoung Jang ),허나연 ( Nayeon Heo ),김규호 ( Gyuho Kim ) 공주대학교 문화재보존과학연구소 2023 문화재과학기술 Vol.18 No.1

본 연구는 채색문화유산을 대상으로 MA-XRF (Macro-XRF)의 활용 가능성을 검토해 보고자 한다. MA-XRF는 분석 면적을 μm 간격의 연속된 포인트로 스캔하여 성분 원소의 정성·정량 데이터를 얻을 수 있고, 이를 매핑 기능을 활용하여 시각적으로 분류할 수 있다. 활용 장비는 Portable MA-XRF인 ELIO (Bruker Nano GmbH, Germany)를 사용하여 전압 40 kV, 전류 20 μA, 면적 50 mm × 45 mm의 조건에서 측정하였다. 예비 분석은 파피루스 달력을 대상으로 ELIO 분석 및 매핑 결과, 포인트 간 거리 1000 μm, 포인트당 측정 시간 1초가 해상도와 측정 시간이 효율적이라 판단하였다. 이 조건으로 직접 제작한 단청 일부(50 mm × 45 mm)에 대한 활용 가능성을 평가하였다. 단청 채색층의 매핑 결과, 두 가지 안료를 혼합하여 사용한 경우 원소 매핑을 통해 시각적으로 구분되고 원소의 검출 강도를 비교하여 동일 색상 내에서 채색층의 두께가 다름이 확인된다. 이와 같은 분석 결과에서 ELIO MA-XRF는 농도 조절, 채색 기법과 보존처리 흔적에 대한 정보를 얻을 수 있으며 채색층의 균질도, 혼합안료의 특성 그리고 덧칠과 수정 흔적을 확인할 수 있는 장점을 가지고 있다. This study is to review the possibility of utilizing MA-XRF (Macro-XRF) targeting colored cultural heritage. MA-XRF can visually show it by utilizing the mapping function based on qualitative and quantitative data of component elements obtained by scanning the analysis area at consecutive points at μm intervals. It was measured at the conditions with voltage of 40 kV, current 20 μA, and area of 50 mm × 45 mm using ELIO (Bruker Nano GmbH, Germany), a portable MA-XRF. In a preliminary survey, the analysis and mapping results of the papyrus calendar with ELIO get the efficient rssults of the resolution and measurement time the condition that the distance between points is 1000 μm and the measurement time per point is one second. And These conditions is evaluated by measuring a part of the produced Dancheong (50 mm × 45 mm). As a result of the mapping of the Dancheong color layer, when two pigments are mixed and used, it is visually classified through elemental mapping, and the thickness of the color layer is different within the same color by comparing the detection intensity of the elements. From these analysis results, information on concentration control, painting techniques, and preservation treatment traces can be obtained, and the homogeneity of the color layer, the characteristics of the mixed pigment, and the overpainting and traces of modification can be confirmed.

뇌성마비로 인한 발육이상 아동 한방치료 1례

임슬우,조장현,김진엽,신중기,하동림,김준형,허나연,김홍준 대한한의학방제학회 2022 大韓韓醫學方劑學會誌 Vol.30 No.4

Objectives : The purpose of this study is to report one case of Korean medical treatment of patient with developmental abnormality by cerebral palsy whose main symptoms are difference in left and right leg length, foot size and construction of right ankle. Methods : We did retrospective study for one developmental abnormality patient who had been treated by herbal medicine(Samul-tang, Yookmijihwang-tang hap Yijin-tang + Sungjang-hwan), acupuncture, and moxibustion for more than one year. The effects of treatment were evaluated by measurement of leg length, foot size and dorsiflexion ROM. Results : After treatment, length and foot size difference between both leg, ROM difference between both ankle were almost reduced. According to the ratio of the right to the left, leg length was improved from 0.91 to 0.98 and foot size was improved from 0.93 to 0.98. The difference in left and right ankle dorsiflexion ROM was improved from 55° to 27.5°. Conclusions : This clinical case study has demonstrated that Korean medicine may be an safe and effective option for treating developmental abnormality.