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함성호,송경,고건일,김재백,손동환,Ham, Seong-Ho,Song, Kyung,Ko, Gun-Il,Kim, Jae-Baek,Sohn, Dong-Hwan 한국약제학회 1994 Journal of Pharmaceutical Investigation Vol.24 No.3
Drug delivery system by the use of red blood cells was established to sustain the release of drugs in the circulatory system by the intravenous injection. The entrapment method by the preswelling technique was re-examined and evaluated for searching the new entrapping conditions without hemolysis. The addition of 4 volume of $0.6{\times}\;hank's$ balanced salt solution (HBSS) into 1 volume of 50% red blood cells suspension did not induce the hemolysis and change the hematocrit level in this experimental condition (within 15 min). Most of daunorubicin could be entrapped into red blood cells within 15 min. While the intracellular adenosine triphosphate (ATP) level followed by the entrapment was reduced to 86% of normal ATP level, the membrane fluidity and the shape factor of red blood cells were not altered. The release rate of daunorubicin from red blood cells was affected by the hemolysis under this condition. To maintain the intracellular ATP in red blood cells, the new reaction buffer was made With the addition of ATP and sodium pyruvate during the entrapment procedure because the hemolysis during the release test would reflect the loss of intracellular ATP that might result in the decrease of the viability in vivo. The addition of ATP raised the intracellular ATP level, which protect the hemolysis during the release test.
Theophylline 의 용출특성과 생체이용성의 상관성에 관한 연구
함성호,한상수,고건일,김재백 圓光大學校 藥品硏究所 1990 藥品硏究所報 Vol.5 No.1
Studies on correlation between dissolution characteristics and bioavailability of theophylline were conducted by dissolution tests of theophylline from newly designed sustained release tablets which contain sustained release granules and monitering the plasma concentration of theophylline after oral doses of newly designed sustained release tablets of 250mg to six healthy volunteers. Sustained release tablets were prepared from plain granules by coating with HPMCAS coating solution. Dissolution profiles showed that approximately 80% of the drug was released in 6 hr. from tablet, indicating that preparations prolonged release of the drug. The plasma concentration profiles after administration of sustained release tablets to six healthy volunteers was similar to the dissolution profiles from the tablets.
함성호,고건일,김재백,손동환 圓光大學校 藥品硏究所 1995 藥品硏究所報 Vol.10 No.1
Drug delivery system by use of red cells was established to sustain the release of daunorubicin. Daunorubicin could be rapidly entrapped into red cellls by addition of distilled water containing daunorubicin and adenosine triphosphate(ATP). Daunorubicin could be entrapped into red cells within 2 minutes. This modified method induced no hemolysis and could sustain the level of intracellular ATP as same as normal red cells. Therefore, this method shows very efficient to make a red cell delivery system which has release pattern withour hemolytic leakage within a desire time since the hemolysis during the release would reflect the loss of intracellular ATP that might result on the decrease of the viability in vivo. Additionally this method would supply rapid and efficient for the dispensing because the short time and small volume are needed for the entrapping procedure.