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대황목단탕의 메티실린 내성 황색 포도상구균에 대한 항균활성
한형선,권동렬,강옥화 대한본초학회 2020 大韓本草學會誌 Vol.35 No.3
Objective : Infectious diseases are a growing problem worldwide by Methicillin-resistant Staphylococcus aureus (MRSA). Daehwangmokdan-tang is one of the oriental medicine prescriptions contained in Principles and Practice of Eastern Medicine. This study investigated the antibacterial activity of EtOH 70% extracts of Daehwangmokdan-tang (DMT) which prescription is composed of oriental medicine against MRSA. Methods : The antimicrobial activity and active concentration of MRSA were verified by measuring the minimum inhibitory concentration (MIC) of DMT. In addition, the effects of the disease were checked by treating the existing antibiotics and large ethanol extract in parallel, and the extent of growth suppression was checked over time. In addition, cell membrane permeability experiment confirmed the effect of large DMT on the immunity mechanism of MRSA. Results : TThe minimum inhibitory concentration of DMT against MRSA is 500 ~ 2000 ㎍/㎖ by broth dilution method. In the checkerboard method, the combinations of DMT with antibiotics has partial synergistic effect or synergy effect and DMT markedly reduced the MICs of the antibiotics oxacillin (OX), gentamicin (GEN) against MRSA. In the inhibition of resistance mechanism of DMT against MRSA, the expression of resistance gene and protein about β-lactam antibiotic was reduced. Also, we observed the effect of DMT about cell membrane permeability against MRSA, and confirmed that DMT suppressed growth of strains by increasing cell membrane permeability and energy metabolism. Conclusion : Basis on the result, we speculate that DMT may be useful for the treatment of MRSA infections when used in combination with β-lactam antibiotic.
다중 프레임에서의 순방향과 역방향을 활용한 적응적 프레임 레이트 증가 변환 방법
양웅선(Woongsun Yang),한형선(Hyungseon Han),박대현(Daehyun Park),김윤(Yoon Kim) 한국정보과학회 2012 정보과학회 컴퓨팅의 실제 논문지 Vol.18 No.11
본 논문에서는 고해상도 비디오를 위한 새로운 프레임 레이트 증가 변환을 제안한다. 블록 기반 알고리즘에서 보다 정확한 움직임 벡터를 찾기 위해 다중 프레임을 통한 양방향 탐색 방법을 제안한다. 먼저, 초기 움직임 벡터를 찾기 위해, 순방향과 역방향으로 움직임 탐색을 실시한다. 초기 움직임 벡터를 기반으로 다중 프레임에서의 양방향 움직임 벡터를 구하고, OBMC를 이용하여 보간 프레임을 구성한다. 실험 결과는 제안하는 방법이 기존의 방법들보다 객관적 평가과 주관적인 화질에서 우수함을 나타낸다. In this paper, we propose a new frame rate up-conversion algorithm for high quality video. In order to find the true motion vectors at the block-based motion compensation, the bi-directional motion estimation is performed on the multiple frames. First, the initial motion vectors are obtained by motion estimation on the forward and the backward direction. Based on the initial motion vectors, the true motion vectors are acquired by the bi-directional motion estimation on the multiple frames. Finally, the interpolated frame is made by the overlapped block motion compensation. Experimental results indicate that the proposed control method provides better visual and PSNR performance than the conventional frame rate up-conversion algorithms.
산사의 NAFLD 보호 효과 및 그 작용기전에 관한 연구
김민철 ( Min-chul Kim ),공룡 ( Ryong Kong ),한형선 ( Hyoung-sun Han ),강담희 ( Dam-hee Kang ),이승진 ( Seung-jin Lee ),이천천 ( Cheon-cheon Lee ),왕서 ( Seo Wang ),권동렬 ( Dong-yeul Kwon ),강옥화 ( Ok-hwa Kang ) 대한본초학회 2018 大韓本草學會誌 Vol.33 No.6
Objectives : Non-alcoholic fatty liver disease (NAFLD) is characterized by the accumulation of hepatic triglycerides (TG) that leads to inflammation and fibrosis. Crataegi Fructus ethanol extract (CE) is a korean traditional herb that used for digestive diseases. It has been investigated that CE has the effect that prevent hepatotoxicity caused by CCl4 or GaIN and regulate the inflammatory in several organs. However, a hypolipidemic effect of CF has not been reported. Methods : The purpose of this study is that examine the lipid accumulation inhibitory effect of CE on NAFLD. We checked the body and liver weight change of MCD-diet induced mice with/without administration of CE. The blood lipid levels of C57BL/6J mice were checked by biochemistry. Also we observed the liver histology of MCD-diet induced mice and investigate the molecular mechanisms in MCD-diet-induced NAFLD in C57BL/6J mice. Results : CE improved MCD-diet-induced lipid accumulation and TG and TC levels. Also, CE decreased hepatic lipogenesis such as SREBP-1, C/EBPα, PPARγ, ACC and FAS. Besides, we also found out that CE increased AMPK phosphorylation. These results indicated that CE has the same ability to activate AMPK and then reduce SREBP-1, and FAS expression, finally leading to inhibit hepatic lipogenesis and hepatic antioxidative ability. Conclusions : In this report, we found CE exerted a regulatory effect on lipid accumulation by decreasing lipogenesis in MCD-diet induced NAFLD model. Therefore, CE extract may be active in the prevention of fatty liver.
대황고(大黃膏)의 메티실린 내성 황색 포도상구균에 대한 항균활성
이순애 ( Sun-ae Lee ),공룡 ( Ryong Kong ),강옥화 ( Ok-hua Kang ),서윤수 ( Yun-soo Seo ),주전 ( Tian Zhou ),김상아 ( Sang-a Kim ),송옥희 ( Ok-hee Song ),김민철 ( Min-chul Kim ),한형선 ( Hyoung-sun Han ),최지나 ( Ji-na Choi ),이영섭 대한본초학회 2017 大韓本草學會誌 Vol.32 No.2
Objectives : Infectious diseases by Methicillin-Resistant Staphylococcus aureus (MRSA) are a growing problem worldwide. Characteristic of MRSA is endlessly mutation to resist antibiotics. Daehwanggo (DHG) is one of the oriental medicine prescriptions contained in Principles and Practice of Eastern Medicine. Daehwanggo was mainly used for external preparation from old times. The purpose of this study is to confirm possibility as supplementary drug of DHG about antibiotics through observation of synergy effect between DHG and commercial antibiotics and to observe restriction on growth of MRSA on any pathway through observation of mechanism. Methods : The minimum inhibitory concentration (MIC) of DHG against MRSA is 500 ~ 2000 ㎍/㎖ by broth dilution method. In the checkerboard method, the combinations of DHG with antibiotics has partial synergistic effect or synergy effect and DHG markedly reduced the MICs of the antibiotics oxacillin (OX), gentamicin (GT) against MRSA. In the inhibition of resistance mechanism of DHG against MRSA, the expression of resistance gene and protein about β-lactam antibiotic was reduced. Also, we observed the effect of DHG about cell membrane permeability against MRSA, and confirmed that DHG suppressed growth of strains by increasing cell membrane permeability. Results : Basis on the result, we speculate that DHG increase antibacterial activity of antibiotics against MRSA by changing the structure of cell wall of MRSA. Conclusions : These data suggest that Daehwanggo possesses possibility as supplementary drug about antibiotics against MRSA.