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RISS 인기검색어
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- 저자 : 한진석 ( Jin Suk Ha (검색결과 2 건)
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각종 신질환에서의 혈청 β2 - microglobulin 측정의 의의
한진석,이정상,궁성수,오하영 대한핵의학회 1985 핵의학 분자영상 Vol.19 No.1
To evaluate change of serum beta₂-microglobulin concentration (sβ₂-MG) and the usefulness of sβ₂-MG and sβ₂-MG/serum creatinine concentration (sCr) ratio in various renal diseases, sβ₂-MG and sCr were measured in 25 normal controls and 90 patients of various renal diseases (16 cases of glomerulonephritis, 12 cases of acute renal failure, 8 cases of chronic renal failure, 24 cases of nephrotic syndrome, 15 cases of tubulointerstitial diseases and 15 cases of lupus nephritis) using Phadebasⓡ Beta₂-Micro Test kits. The results were as follows; 1) In normal control, the mean value of sβ₂-MG was 1.65±0.41 ㎎/ι and the mean value of sβ₂-MG/sCr ratio was 0.14±0.05. 2) In various renal diseases, the mean value of sβ₂-MG was 6.74±5.47 mg/ι. The mean value of sβ₂-MG/sCr ratio was 0.24±0.11 and significantly elevated than that of normal contro1. (P〈0.05). 3) The correlation between sβ2-MG and sCr in glomerular and tubulointerstitial disease was log sβ₂-MG=0.90 log sCr-0.48 and its correlation coefficie5). 4) In glomerular disease, the correlation between sβ2-MG and sCr was log sβ2-MG=0.89 log sCr-0.46 (r-0.76) and in tubulointerstitial disease, it was log sβ2-MG=0.95 1og sCr-0.59 (r-0.87). There was no significant difference between the two groups (p〈0.05). 5) Among 32 cases of glomerular and tubulointerstitial disease patients, whose sCr was within normal range, 17 cases showed elevated sβ₂-MG. The mean values of sβ2-MG/sCr ratio in these patients was 0.30±0.14 and significantly elevated than that of normal control (p〈0.05). 6) In 15 cases of lupus nephritis, 12 cases showed elevated sβ2-MG with normal sCr and 12 cases showed elevated sβ₂-MG/sCr ratio. With above results, It was found that the sβ₂-MG can be used as an index of glomerular filtration rate as in the case of sCr and thats sβ₂-MG/sCr ratio can be used as a tool in early detection of slightly decreased glomerular filtration rate and in detection of the renal disease of increased β₂-MG production.
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