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당뇨병환자의 신장이야기-당뇨병환자의 신장합병증 예방과 관리
한동철,Han, Dong-Cheol 사단법인 한국당뇨협회 2007 당뇨 Vol.214 No.-
혈관이 상하게 되고, 혈압이 낮아도 소변이 나오지 않게 됩니다. 또한 혈관뿐만 아니라 소변이 지나가는 관도 매우 작고 가늘어서 요세관이라고 합니다. 조그마한 혈관들이 빽빽하게 지나가는 자리 옆에 소변이 지나가는 자리 역시 매우 빽빽하게 들어차 있습니다. 한번 콩팥이 망가지면 잘 고쳐지지 않는 이유가 이러한 모습 때문입니다.
페니토인의 장기 복용으로 발생한 감각운동성 다발성 신경병증
한동철,박현미,신동진,이영배,Han, Dong-Chul,Park, Hyeon-Mi,Shin, Dong-Jin,Lee, Yeong-Bae 대한임상독성학회 2006 대한임상독성학회지 Vol.4 No.2
Phenytoin has been used globally as an effective anticonvulsant. Among its adverse effects, peripheral neuropathy including polyneuropathy has sometimes been reported. We report a case of sensorimotor polyneuropathy associated with high serum level and long-term phenytoin therapy. A 29-year-old male presented with motor weakness in all extremities. He was treated with phenytoin (400 mg/day) for about eight years because of generalized tonic clonic seizure. During none conduction assessment, sensorimotor polyneuropathy was discovered.
한동철,오영미,정성해,구자원,김지수 대한신경과학회 2007 대한신경과학회지 Vol.25 No.1
Background: Acoustic stimulation of the saccule can evoke the vestibulocolic reflex and the inhibitory potential can be measured in the ipsilateral sternocleidomastoideus as a vestibular evoked myogenic potential (VEMP). We investigated the saccular dysfunction in patients with Ménière's syndrome by using VEMP, and correlated the findings with those of other vestibular function tests. Methods: Thirty-six patients, 29 with Ménière's disease and 7 with delayed endolymphatic hydrops, underwent interictal VEMP. Eight patients reported Tumarkins otolithic crisis. The patients also had a bithermal caloric test, testing of the subjective visual vertical (SVV), and brainstem auditory evoked potentials (BAEP) in addition to pure tone and speech audiometry. Results: Abnormal VEMP was observed in 21 (58.3%) patients. All the patients with abnormal VEMP showed decreased amplitude or absence of VEMP in the lesion side. Three of them also exhibited delayed p13 or n23 latency. The VEMP was abnormal in four of the 13 patients with normal calorics, 13 of the 21 with normal SVV, and 11 of the 21 with normal BAEP. The abnormal VEMP was more common in patients with delayed endolymphatic hydrops (71.4%) and Tumarkins otolithic crisis (75.0%), but without statistical significance. Conclusions: VEMP detects saccular dysfunction in Ménière's syndrome. The abnormal VEMP in some patients with normal calorics, SVV or BAEP suggests differential involvement of the vestibular subsystem in Ménières syndrome especially in the early stage.