http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
신규 퀴놀론 항균제 DW-116 의 in vitro 및 in vovp 항균활성
이진(Jin Lee),정용호(Yong Ho Chung),윤성준(Sung June Yoon),이덕근(Dug Keun Lee),황연하(Yun Ha Hwang),한경오(Kyung Oh Han),양희복(Hee Bog Yang) 한국응용약물학회 1997 Biomolecules & Therapeutics(구 응용약물학회지) Vol.5 No.2
The in vitro and in vivo antibacterial activity of DW-116, a newly synthesized fluoroquinolone, were compared with those of other quinolones. DW-116 exhibited more potent antibacterial activity than rufloxacin and lower activity than ofloxacin and ciprofloxacin in in vitro assay. But, DW-116 particularly showed strong activity against the family of staphylococci including methicillin-sensitive staphylococcus and its activity was more active than that of ciprofloxacin. The time-kill curve studies showed rapid bactericidal activity for DW-116. The post-antibiotic effect of DW-116 was observed between 0.66 and 5 hours. The therapeutic efficacy of DW-116 against respiratory infection with P. aeruginosa was as strong as that of ciprofloxacin and its effect against urinary tract infection with E. coli was more effective than rufloxacin. The excellent therapeutic efficacy of DW-116 against these local infections is due to its good pharmacokinetic profiles.
이관복,박승춘,한경오,윤호인 충남대학교 수의과대학 동물의과학연구소 1994 動物醫科學硏究誌 Vol.1 No.-
It is important to study the activity of drug biotransformation enzymes, because from a pharmacological and therapeutic point of view these enzymes are resposible for eliminating most drugs. Their level is ciritical when deciding the dose regimen. (From a toxicological perspective, the role of these enzymes varies, with some of them being directly responsible for activation of certain chemicals to reactive intermediates with deleterious consequence to the animal.) Experiments were designed to measure in vitro, the activity of drug metabolizing enzymes in liver of Korean native cattle. The microsomal monooxygenase activities were evaluated utilizing specific substrates. The activities of BPDM and TST 6β-hydroxylase were seemed to be high level relatively to other monooxygenzses such as ECOD, EROD and AH. Interestingly, TST 16α-hydroxylase which is a maker enzyme for CYP ⅠLA was not detected in Korean native cattle. These results sugest that Korean native cattle have high contents of CYP IIB1 and CYP IIIA.