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- 저자 : 한경근(Kyung Geun Han) (검색결과 2 건)
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한경근(Kyung Geun Han),배성진(Sung Jin Bae),김성은(Seong Eun Kim),김기현(Ki Hyun Kim),박정하(Jeong Ha Park),지삼룡(Sam Ryong Ji),임정현(Jeong Hyun Lim),장광열(Goang Yul Jang) 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.3
N/A There are some clinical evidences that hepatitis B virus(HBV) infection may cause IgA nephropathy. To evaluate clinical significances and pathogenetic roles of HBV infection in patients with IgA ne-phropathy, we studied that varius clinical and lab- oratory findings in 172 patients with IgA nephrop-athy as serum hepatitis B surface antigen(HBsAg) positive(19 cases) and negative group(153 cases). The result was as following: 1) The incidence of positive serum HRsAg was 11.0%(19/172 cases) in patients with IgA nephrop- athy and it was higher than that of the randomized age-sex matched general population(4.1%) but has no significance statistically. 2) There was no significant differences in incidence of hypertension, serum levels of IgA, C3, SGOT, SGFf between HBsAg postive and negative group. 3) The cases of nephrotic range proteinuria(3.5g/ day) was more prevalent in HBsAg positive group (31.6%) than that in negative group(7.2%). significantly(p<0.05). 4) The cases of impaired renal function(serum creatinine more than 1.4mg/dL) were more frequent in HBsAg positive group(42.19%) than that in neg-ative group(13.1%) significantly(p<0.05).
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성인 미세변화신증후군 환자에서 β₂-Microglobulin 량에 의한 스테로이드 치료 반응의 예측
김기현,김성은,우영석,배성진,장광열,한경근 대한신장학회 1998 Kidney Research and Clinical Practice Vol.17 No.6
Urinary protein per se causes renal tubular injury and stimulates immunologic reaction. The extent of proximal tubular injury can be estimated by measuring the amount of 24 hours urinary ?2-microglobulin(U ?2-MG). The aim of this study was whether U ?2-MG level could predict the response to the initial steroid treatment for the patients with minimal change nephrotic syndrome(MCNS). We analyzed 58 adult patients(33 M, 25 F), aged 33?15 years(range 16-76), with biopsy-proven MCNS treated with 40 to 60mg of oral prednisolone daily up to 16 weeks. The responsiveness(44 cases) inculded complete and partial remission or steroid resistance(14 cases). No difference was found between the steroid responsive and resistant group with regard to age, BUN, serum creatinine, albumin, cholesterol, and urinary protein. The levels of U ?2- MG(?g/g creatinine) were 250808?478917 and 1648?2386 in resistan ??Kwang-Yul Chang, et al.:Prediction of Steroid Responsiveness in Adult Minimal Change Nephrotic Syndrome Using -Microglobulint group and responsive group, respectively(P<0.05). The cut off value was 400?g/ g creatinine with 78% of sensitivity and 48% of specificity. The likelihood ratio for the resistance was 2.5 to 2.8 with the U ?2-MG levels over 400 ug/g creatinine and was 0.2 to 0.3 below that value. Multivariate analysis confirmed that higher U ?2- MG level was associated with a lower likelihood of steroid responsiveness, independent of age, sex, creatinine, serum protein, and urinary protein. This study showed that the pretreatment U ?2- MG level may be used to identify subgroup of patients with MCNS who are more likely to be responsive to initial steroid treatment.
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