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10cm 이상의 거대 간세포암의 우엽 절제술에서의 전방 접근법
김태환(Tae-Hwan Kim),이승규(Sung-Gyu Lee),송기원(Gi-Won Song),황신(Shin Hwang),김기훈(Ki-Hun Kim),안철수(Chul-Soo Ahn),문덕복(Deok-Bog Moon),하태용(Tae-Yong Ha),정동환(Dong-Hwan Jung) 한국간담췌외과학회 2008 한국간담췌외과학회지 Vol.12 No.4
Purpose: This study was conducted to evaluate the technical feasibility and the impact on survival of the anterior approach technique for resecting a huge hepatocelluar carcinoma (HCC) as compared with the conventional approach technique. Methods: We performed a retrospective observational study on 57 patients who underwent right hemihepatectomy for a huge HCC over than 10cm in diameter. A total of 57 patients were divided into two groups; the anterior approach technique group (AA group, n=23) and the conventional approach group (CA group, n=34). The overall perioperative data was collected and analyzed. The post-hepatectomy liver function, the operative mortality and morbidity and the survival outcome were compared between the two groups. Results: The post-hepatectomy liver function profile was not significantly different between the two groups. The operative mortality and morbidity were comparable in both groups. The transfusion requirement was not significantly different in both groups (p=0.470), but the cases without transfusion were more common in the AA group (p=0.046). The tumor with an advanced stage (UICC stage III/IV) was significantly more frequent in the AA group (p=0.014). The overall patient survival and disease-free survival was not significantly different between the two groups despite of the difference of the disease stage between the 2 groups (p=0.050, p=0.822). Pulmonary metastasis was more common in the CA group (p=0.035). Conclusions: Despite of the advanced disease state, the anterior approach technique resulted in comparable operative and survival outcomes as compared with the outcomes of the conventional approach technique. In terms of the technical feasibility, the anterior approach technique may reduce the required amount of transfusion when performing hepatectomy for a huge HCC.
플라즈마 EGR 조합시스템 디젤기관의 성능 및 배기 배출물 특성
배명환(Myuang-whan Bae),하태용(Tae-yong Ha),김호갑(Ho-gab Kim),박재윤(Jae Yoon Park),하현진(Hyun JIN ha) 한국자동차공학회 2003 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
The effects of non-thermal plasma reactor and recirculated exhaust gas on performance and exhaust emissions under four kinds of engine loads were experimentally investigated by using a four-cycle, four-cylinder, swirl chamber type, water-cooled diesel engine with a combined plasma EGR system operating at three kinds of engine speeds. The purpose of this study is to develop the combined exhaust gas recirculation(EGR) control system with a non-thermal plasma reacto for reducing NOⅹ and soot emissions simultaneously in diesel engines. The EGR system is used to reduce NOⅹ emissions, and the non-thermal plasma reactor is used to reduce soot emissions. The plasma system in this study is a flat-to-flat type reactor operated by a plasma power supply. The experiments arc performed at the fixed fuel injection timing of 4˚ ATDC regardless of experimenlal conditions. It is found that NOⅹ and soot emissions are decreased, especially soot emissions are markedly reduced at the middle loads, as the applied electrical voltage of plasma reactor is elevated.<br/>
Assessment of Genetic Diversity of Horse Breeds Using Microsatellite Makers
Ji-Hye Jung(정지혜),Mi-Rang Lee(이미랑),Tae-Yong Ha(하태용),Seon-Ku Kim(김선구),Teak-Soon Shin(신택순),Han-Seok Kang(강한선),Hong-Gu Lee(이홍구),Gil-Jae Cho(조길재),Kyung-Do Park(박경도),Byung-Wook Cho(조병욱) 한국생명과학회 2009 생명과학회지 Vol.19 No.2
본 연구는 마품종 간의 유전적 배경과 다양성을 분석하기 위해 제주마, 경주마, 더러브렛, 몽고마, 쿼터호스, 일본마를 기초 축으로 생물체 집단 간의 유전적 배경 및 관련성을 연구하는데 도움 되는 microsatellite marker를 사용하여 13종의 좌위에 대한 개체별 유전자형을 분석하여 대립 유전자별 빈도에 있어 품종별 차이를 보이는 microsatellite loci들을 나타냈다. 전체 개체들의 유전적 다양성을 나타내는 유전자 좌위별 품종별 기대 이형질성은 0.669-0.869를 나타냈고, 전체 집단 간의 유전자 분화정도는 0.061-0.219를 나타냈다. 이러한 대립 유전자 빈도를 근거로 하여 DISPAN 프로그램을 이용하여 집단 간 표준 유전적 거리를 도식하여 유전자 좌위별 유전적 거리는 0.137-0.414를 나타내어 마품종간의 유전적 다양성과 관련성을 고찰할 수 있게 되었다. 따라서 초위성체 유전자 표지를 이용하여 집단 내의의 혈통분석 및 분자 진화학을 연구하는데 도움이 될 것으로 사료된다. To assist in selection schemes we estimate the genetic diversity of the horse breeds. Genetic diversity at 13 microsatellite loci was compared in six horse breeds : Jeju Native Horse, American Quarter, Jeju Racing Horse, Mongolian Horse, Japanese Horse and Thoroughbred. All of the equine microsatellite used in this study were amplified and were polymorphic. The expected total heterozygosity over all the populations varied between 0.669 and 0.869 and the expected heterozygosity within population range from 0.569 to 0.219 in this study. The low coefficient of gene differentiation value showed that only 0.118 of the diversity was between horses breeds. The constructed dendrogram from the genetic distance matrix showed little differentiation between horse breeds using DISPAN program. The genetic distance using 13 microsatellites ranged between 0.137 and 0.414 for the six horse breeds. These results confirm the potential use of equine microsatellite loci as a tool for genetic studies in horse populations. The genetic diversity of the six horse breeds to each other closed to their geographical distribution. Suggesting that the loci would be suitable for horse breeds parentage testing. Therefore, Microsatellite marker seems to be very useful for clarifying the evolutionary relationships of closely related populations.
스크러버형 EGR시스템 디젤기관의 배기 배출물에 미치는 흡입 혼합기 온도의 영향
배명환(Myung-whan Bae),류창성(Chang-sung Ryu),하태용(Tae-yong Ha),김진옥(Jin-ok Kim),김형만(Hyung-Man Kim) 한국자동차공학회 2002 한국자동차공학회 춘 추계 학술대회 논문집 Vol.2002 No.5_1
The effects of intake mixture temperature on performance and exhaust emissions under four kinds of engine loads were experimentally investigated by using a four-cycle, four-cylinder, swirl chamber type, water-cooled diesel engine with scrubber EGR system operating at three kinds of engine speeds. The EGR system is used to reduce NOx emissions. And a novel diesel soot-removal device with a cylinder-type scrubber which has five water injection nozzles is specially designed and manufactured to reduce soot contents in the recirculated exhaust gas to the intake system of the engine. The influences of cooled EGR and water injection, however, would be included within those of scrubber EGR system. In order to study the effect of intake mixture temperature, a intake mixture heating device which has five heating coils is made of a steel drum. It is found that NO. emissions are decreased, while soot emissions are increased owing to the decrease in intake and exhaust oxygen concentrations and the increase in equivalence ratio. The influence of cooled EGR is considerably great due to intake mixture temperature.
간이식 수술 후 재발된 B형 간염 환자 및 de novo 감염 환자에서 Adefovir의 치료 효과에 대한 예비 보고
김건국 ( Keon Kuk Kim ),김기훈 ( Ki Hun Kim ),황신 ( Shin Hwang ),안철수 ( Chul Soo Ahn ),문덕복 ( Deok Bog Moon ),하태용 ( Tae Yong Ha ),이승규 ( Sung Gyu Lee ) 대한소화기학회 2005 대한소화기학회지 Vol.45 No.3
Background/Aims: Anti-viral therapy using hepatitis B immune globulin and lamivudine could not prevent HBV recurrence after liver transplantation (LT) completely. Adefovir dipivoxil is a acyclic nucleotide phosphate analogue and known to have potent anti-