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하새현,류지훈,홍석진,손숙자 대한피부과학회 2002 大韓皮膚科學會誌 Vol.40 No.12
Rowell's syndrome is described as erythema multiforme(EM)-like lesions in the presence of lupus erythematosus(LE) associated with immunoserological characteristics of speckled antinuclear antibodies and positive tests for anti-Ro/La antibodies and rheumatoid factor. We report a case of Rowell's syndrome in a 28-year-old woman with systemic lupus erythematosus for 13 years, who presented with targetoid eruptions on the right arm and with positive immunoserologic findings as above. (Korean J Dermatol 2002;40(12) 1584∼1586)
하새현,류지훈,이증,손숙자 대한피부과학회 2003 대한피부과학회지 Vol.41 No.2
Pseudocyst of the auricle is a disease of degenerative cartilage associated with asymptomatic swelling of the external ear caused by an intracartilaginous accumulation of serous fluid. Histological examination shows an intracartilaginous cavity without an epithelial lining. This disease is characterized by frequent relapses despite various therapeutic approaches. In this report we describe one patient with pseudocyst of the auricle who was successfully treated with intralesional injection of 1 ㎎/㎖ of minocycline hydrochloride. (Korean J Dermatol 2003;41(2) : 269∼271)
유방외 Paget 병의 임상, 병리조직 및 면역조직화학적 연구
하새현 ( Ha Sae Hyeon ),이증 ( Lee Jeung ),박찬금 ( Park Chan Geum ),손숙자 ( Son Sug Ja ) 대한피부과학회 2004 대한피부과학회지 Vol.42 No.1
N/A Background: Extramammary Paget`s disease (EMPD) is an uncommon but distinctive tumor. Definitive diagnosis requires biopsy of the lesion and immunohistochemical staining. Immuno-histochemical study using anti-cytokeratin monoclonal antibodies may be helpful for differentiating EMPD from other similar skin lesions and primary EMPD from pagetoid spread of underlying regional internal malignancy (secondary EMPD). Objective: The purpose of this study was to identify clinical findings, histopathologic features and immunohistochemical characteristics of EMPD. Methods: The twelve cases diagnosed as EMPD at our institution over ten years were included. Clinical records and pathology slides of the patients were reviewed retrospectively. Immunohi-stochemical stains for CK7, CK20, CEA, EMA, PSA, GCDFP15 and mucin stains such as PAS, d-PAS, alcian blue (pH 2.5) were done using paraffin blocks. Results: 1. In most cases, EMPD developed on the scrotum of senile male patients. 2. In the pathologic findings, Paget cells were observed from the epidermis only in 2 cases, from the epidermis and intradermal skin appendages in 7 cases and from the epidermis only in 2 cases, from the epidermis and intradermal skin appendages in 7 cases and from the dermis in 3 cases. 3. In all cases except for the single case associated with a transitional cell carcinoma of the urinary bladder, there were histochemical findings of alcian blue-, PAS- and immunohistochemical findings of CK7+, CK20-, CEA+, EMA+. 4. In the single case associated with transitional cell carcinoma of the urinary bladder, there were histochemical findings of alcian blue-, PAS- and immunohistochemical findings of CK7+, CK20+, CEA-, EMA-. Conclusion: The combination of CK7 and CK20 demonstrates these to be useful markers in distinguising primary EMPD from a pagetoid Paget cells suggest underlying regional internal malignancy. (Korean J Dermatol 2004;24(1):1~8)