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중등증-중증의 한국인 건선 환자에서 Secukinumab의 효과와 안전성에 관한 연구
하대룡 ( Dae-lyong Ha ),김우일 ( Woo-il Kim ),양민영 ( Min-young Yang ),이원구 ( Won-ku Lee ),김태욱 ( Taewook Kim ),박성민 ( Sungmin Park ),이현주 ( Hyun Joo Lee ),김건욱 ( Gun-wook Kim ),김훈수 ( Hoon-soo Kim ),고현창 ( Hyun-cha 대한피부과학회 2019 대한피부과학회지 Vol.57 No.1
Background: Secukinumab, a fully human monoclonal antibody that targets interleukin (IL)-17A, which is a central cytokine in the pathogenesis of psoriasis, has emerged as a promising treatment for moderate to severe psoriasis. However, to date, there are no real-world data for secukinumab in Korean patients with psoriasis. Objective: To assess the clinical efficacy and safety of secukinumab in Korean patients with psoriasis. Methods: Prospective data were gathered during follow-up from 28 consecutive patients with chronic plaque-type psoriasis treated with secukinumab for minimum of 12 weeks at a single referral center. Patient demographics, Psoriasis Area Severity Index (PASI) score, Physicians’ Global Assessment (PGA), Dermatologic Life Quality Index (DLQI), and adverse events were investigated. Results: The mean PASI score was significantly decreased after the induction period of secukinumab treatment (paired t-test, p<0.05). Of the 28 patients, 17 (60.7%) had obtained near complete clearance (PASI 90) at the last follow-up visit. No unexpected adverse events, other than nasopharyngitis, were observed. Conclusion: Secukinumab can be of benefit for the treatment of Korean patients with psoriasis, as the treatment was associated with a rapid and satisfactory response and safety profile. (Korean J Dermatol 2019;57(1):9∼14)
하대룡 ( Dae-lyong Ha ),진현주 ( Hyunju Jin ),유향석 ( Hyang-suk You ),심우행 ( Woo-haing Shim ),김정민 ( Jeong-min Kim ),김건욱 ( Gun-wook Kim ),김훈수 ( Hoon-soo Kim ),고현창 ( Hyun-chang Ko ),김병수 ( Byung-soo Kim ),김문범 ( M 대한피부과학회 2018 大韓皮膚科學會誌 Vol.56 No.4
Unilateral linear capillaritis (ULC) is a rare variant of pigmented purpuric dermatosis (PPD). ULC is clinically characterized by unilateral linear macules on the lower extremities, which fade spontaneously. We present three patients with linearly distributed purpuric macules on only one side of the lower extremities. Skin biopsy showed histopathological features of PPDs. We diagnosed ULC based on these clinicopathological findings. For all patients, the skin lesions began to fade spontaneously within several months to a few years after onset. ULC has been reported rarely, with only about 20 cases worldwide and no cases described in the Korean literature. (Korean J Dermatol 2018;56(4):273∼275)
김연아 ( Yeona Kim ),하대룡 ( Dae-lyong Ha ),손진화 ( Jin-hwa Son ),신기혁 ( Kihyuk Shin ),이정수 ( Jungsoo Lee ),김훈수 ( Hoon-soo Kim ),고현창 ( Hyun-chang Ko ),김병수 ( Byung Soo Kim ),김문범 ( Moon-bum Kim ) 대한피부과학회 2020 大韓皮膚科學會誌 Vol.58 No.9
A poroma is a benign adnexal neoplasm originating from the sweat gland duct. It usually presents clinically as a soft erythematous or flesh-colored papule, plaque, or nodule on the palms and soles. In most cases, poromas manifest as a solitary lesion, but rarely, multiple lesions have been reported and are defined as poromatosis. Although the pathogenesis is unclear, poromatosis is known to be associated with actinic damage, human papillomavirus infection, radiation therapy, or polychemotherapy. Herein, we describe a 53-year-old woman who had multiple erythematous papules on her feet for a year. She had a medical history of acute lymphoblastic leukemia and had undergone polychemotherapy with stem cell transplantation. To our knowledge, poromatosis related to chemotherapy is a rare entity, and our case could be attributed to the theory that using polychemotherapy can induce poromatosis. (Korean J Dermatol 2020;58(9):617∼619)
김연아 ( Yeona Kim ),하대룡 ( Dae-lyong Ha ),손진화 ( Jin-hwa Son ),신기혁 ( Kihyuk Shin ),이정수 ( Jungsoo Lee ),김훈수 ( Hoon-soo Kim ),고현창 ( Hyun-chang Ko ),김병수 ( Byung Soo Kim ),김문범 ( Moon-bum Kim ) 대한피부과학회 2020 大韓皮膚科學會誌 Vol.58 No.9
Background: Tumoral calcinosis is characterized by the deposition of calcific masses around major joints, and it often causes significant impairment of joint function. Dermatologists sometimes encounter patients with a subcutaneous hard mass around the joint. However, there are few studies about tumoral calcinosis in the dermatologic literature, especially in Korea. Objective: The aim of this study was to determine the clinical characteristics of tumoral calcinosis. Methods: We reviewed the clinical photographs, medical records, and biopsy specimens of 11 cases of tumoral calcinosis seen at our clinic in 10 years. Results: All 11 patients were female, and the mean age at onset was 58.5 years. The mean duration of the disease was 7.1 years. Most patients (9, 81.8%) presented with an asymptomatic subcutaneous hard mass around the iliac crest. None of the patients had a family history, or abnormal serum calcium, phosphorus, and parathyroid hormone levels. All patients underwent surgery for treatment. Conclusion: Tumoral calcinosis can occur sporadically without metabolic disease. Therefore, careful history taking and biochemical work-up involving the metabolism of calcium and phosphorus should be performed. If there is no peculiarityon examination, the lesion is cured by resection. Although the sample size of this study is small, it can be inferred that the characteristics of tumoral calcinosis in Korea can be described by its predominant sex preponderance and location, that is, the female sex and the iliac crest, respectively. (Korean J Dermatol 2020;58(9):596∼600)
Guselkumab 사용 후 호전된 Acrodermatitis Continua of Hallopeau 1예
김지호 ( Jin Ho Kim ),하대룡 ( Dae-lyong Ha ),장용현 ( Yong Hyun Jang ) 대한피부과학회 2024 대한피부과학회지 Vol.62 No.1
Acrodermatitis continua of Hallopeau (ACH) is a rare type of pustular psoriasis that causes periungual sterile pustules, paronychia, onychodystrophy, osteolysis, and atrophic skin. This condition is known for being resistant to conventional anti-psoriatic treatments. Therefore, biologics have been explored as potential management options for ACH. A 48-year-old male presented with erythematous swelling, pustular eruptions, desquamation, and nail dystrophy on his left third fingertip for a year. Despite various anti-psoriatic treatments, including 308 nm excimer laser, oral cyclosporine, acitretin, and methotrexate, the symptoms persisted. After 9 years of experiencing this condition, the patient was started on guselkumab (an interleukin-23 inhibitor), and showed significant improvement after eight injections. The patient was in good health without any adverse effects. This case report highlights the potential effectiveness of guselkumab in the treatment of refractory ACH. (Korean J Dermatol 2024;62(1):53∼57)
동일 부위에 발생한 유방외 파젯병과 뾰족콘딜로마의 연관성
유향석 ( Hyang-suk You ),하대룡 ( Dae-lyong Ha ),김정민 ( Jung-min Kim ),김건욱 ( Gun-wook Kim ),문제호 ( Je-ho Mun ),송마가렛 ( Margaret Song ),고현창 ( Hyun-chang Ko ),김병수 ( Byung-soo Kim ),김문범 ( Moon-bum Kim ),김훈수 ( Hoo 대한피부과학회 2018 大韓皮膚科學會誌 Vol.56 No.1
Extramammary Paget’s disease (EMPD) is a rare skin neoplasm, which usually affects the anogenital region of older individuals. Condyloma accuminatum is a very common benign human papilloma virus (HPV)-associated keratinous neoplasm affecting the anogenital region of children and adults. To our knowledge, two cases of simultaneous occurrence of EMPD and condyloma accuminatum have been reported in the written English literature until now. We report a case of a 58-year-old man with simultaneous occurrence of EMPD and condyloma accuminatum in a lesion for the first time in Korea. Histologic, immunohistochemical and HPV-PCR test results were also described to analyze the development of the lesion and the correlation between EMPD and condyloma accuminatum. (Korean J Dermatol 2018;56(1):53∼56)