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표주연,홍순원,김지섭,최성은,신은아,양석우,박정수,김석모 연세대학교의과대학 2017 Yonsei medical journal Vol.58 No.1
We describe herein histologic, immunohistochemical, and molecular findings and clinical manifestations of a rare case of an extremelywell differentiated papillary thyroid carcinoma (EWD-PTC). Similarly, it is also difficult to diagnose follicular variant papillarythyroid carcinoma (FVPTC), whose diagnosis is still met with controversy. A recently reported entity of well-differentiated tumor of uncertain malignant potential (WDT-UMP) is added to the diagnostic spectrum harboring EWD-PTC and FVPTC. We reportthis case, because EWD-PTC is different from FVPTC in its papillary architecture, and also from WDT-UMP in its recurrence and metastatic pattern. These morphologically deceptive entities harbored diagnostic difficulties in the past because the diagnosisdepended solely on histology. However, they are now diagnosed with more certainty by virtue of immunohistochemical and molecularstudies. We experienced a case of EWD-PTC, which had been diagnosed as adenomatous hyperplasia 20 years ago and manifested recurrence with lymph node (LN) metastasis 7 years later. After another 7 years of follow-up, a new thyroid lesion had developed, diagnosed as FVPTC, with LN metastasis of EWD-PTC. One year later, the patient developed metastatic FVPTC in the skull. Immunohistochemically, the EWD-PTC was focally positive for CK19, negative for galectin-3, and focally negative for CD56. Molecular studies revealed BRAF-positivity and K-RAS negativity. The FVPTC in the left thyroid showed both BRAF and K-RAS negativity. In conclusion, EWD-PTC and FVPTC share similar histologic features, but they are different tumors with different molecularbiologic and clinical manifestations. A large cohort of EWD-PTC should be included in further study.
표주연,홍순원,최성은,신은아,구자승 대한병리학회 2017 Journal of Pathology and Translational Medicine Vol.51 No.5
Background: When differential diagnosis is difficult in thyroid follicular lesions with overlapping histological features, the immunohistochemical staining can help confirm the diagnosis. We aimed to evaluate the effectiveness of rapid immunohistochemical stains of CD56 and cytokeratin 19 on frozen sections of thyroid follicular lesion and explore the possible gains and limitations of the practice. Methods: Eighty-six nodules of 79 patients whose intraoperative frozen sections were selected as the control group, and 53 nodules of 48 patients whose intraoperative frozen sections were subject to rapid immunohistochemistry were selected as the study group. Results: Five nodules (6%) in the control group were diagnosed as follicular neoplasm and six nodules (7%) were deferred. In the study group, six nodules (11%) were follicular neoplasm and none were deferred. Three nodules (4%) in the control group showed diagnostic discrepancy between the frozen and permanent diagnoses, but none in the study group. The average turnaround time for the frozen diagnosis of the control group was 24 minutes, whereas it was 54 minutes for the study group. Conclusions: Intraoperative rapid immunohistochemical stains significantly decreased the diagnostic discrepancy in this study. Considering the adverse effects of indefinite frozen diagnosis or discrepancy with permanent diagnoses, the intraoperative rapid immunohistochemical stain can help to accurately diagnose and hence provide guidance to surgical treatment.
자궁목암종에서 Hypoxia Inducible Factor-1α의 발현과 Cyclin A1, Cyclin B1 발현 및 임상병리학적 인자들과의 연관성
표주연,조재호,김영태,조남훈,김현기,박종필 대한병리학회 2009 Journal of Pathology and Translational Medicine Vol.43 No.1
Background : Hypoxia inducible factor-1α(HIF-1α) is a transcription factor for various target genes that are involved in adapting cells to hypoxia. It promotes cell proliferation and survival via modulation of such cell cycle regulators such as cyclin A1 and cyclin B1 in response to hypoxia. This is associated with local failure of radiotherapy, which renders a poor prognosis for cervical carcinoma. Methods : Using the tissue histologic sections and a tissue microarray of the archived biopsy and surgical specimens of uterine cervical carcinoma from 57 patients who were treated with radiation therapy alone, we performed immunohistochemical staining for HIF-1αand cyclin A1 and B1 to evaluate the correlations between the expressions of these proteins in tumors and the clinicopathologic parameters associated with the prognosis. Results : The large tumor cell nests and invasive front margins of the tumors showed comparatively intense immunoreactivity of HIF-1α. There was no significant correlation between the HIF-1α, cyclin A1 and cyclin B1 expressions and the clinicopathologic factors. Conclusions : The HIF-1αexpression showed marked intra-tumoral heterogeneity. The HIF-1αexpression is neither a powerful predictor of resistance to radiotherapy nor is it a poor prognostic marker in cervical carcinoma patients who are treated with radiotherapy. The expressions of cyclin A1 and cyclin B1 are neither independently associated with the response of radiation therapy nor are they associated with the prognostic parameters of uterine cervical carcinoma.
표주연,신숙 한국동물분류학회 2011 Animal Systematics, Evolution and Diversity Vol.27 No.2
Tunicates were collected from three harbors (Gampo, Bangeojin, Daebyeon) in Gyeongsangnam-do and one harbor (Seogwipo) in Jejudo Island during the period from August 2008 to January 2011 and were identified on the basis of their morphological characteristics. Among them, colonial tunicate Clavelina lepadiformis (Müller, 1776) belonging to the family Clavelinidae was found to be an invasive alien species introduced from the North Atlantic, and this is the first record of its occurrence in Korea.
표주연,노재윤,전순호 대한흉부외과학회 2013 Journal of Chest Surgery (J Chest Surg) Vol.46 No.6
Nonossifying fibromas are not uncommon, but those described in the rib are unique. We report the case of a 15-year-old patient with symptoms of chest wall pain for 5 days who underwent a video-assisted thoracoscopic rib resection for a 2.5-cm rib mass. Unexpectedly, pathological results revealed a nonossifying fibroma of the rib. The results showed excellent cosmesis and new bone formation because of the preservation of the overlying periosteum.
총설: 인지과학적 기법의 수사 활용에 관한 고찰: 피해자와 목격자의 기억을 중심으로
함근수,표주연,주이현,심유진 한국과학수사학회 2022 과학수사학회지 Vol.16 No.1
피해자 및 목격자 등 인적 자원에 대한 수사에 있어서 가장 중요하게 고려해야할 요인 중 하나는 정확하고 많은 정보를 어떻게 진술할 수 있게 할 것인가이다. 그리고 피해자 및 목격자의 진술 내용을 어느 정도 신뢰할 수 있는 지를 평가하거나 분석함으로써 수사 활용 가능성을 알아보는 것 또한 중요하다. 본 총설에서는 인지신경과학적 기법의 수사활용 가능성을 알아보기 위하여 비침습적이고, 비교적 사용하기 쉬운 수평 도약 눈 운동을 통한 기억고양 기법과 뇌파의 EEG 및 ERP, fNIRS, 그리고 EEG+fNIRS 하이브리드 기법을 활용한 기억정확성 평가 기법에 대하여 알아보았다. 또한 각 인지신경과학적 기법의 이론적 토대와 관련 연구 동향을 살펴보았으며, 일반적인 범죄 피해자 및 목격자 기억의 특성과 인지신경과학적 기법의 수사활용에 있어서 제한점과 고려사항들을 알아보았다. 앞으로는 인지신경과학적 기법들을 범죄 피해자 및 목격자의 기억 고양과 기억정확성 평가에 적용한 인적 자원에 대한 수사의 과학화뿐만 아니라, 수사의 효율성을높이기 위한 방법론적 변화가 필요하다. 그러므로 인지신경과학에 기반을 둔 인지신경과학적 기법들이 이러한 방법론적 변화의 중요한 토대를 제공할 것이다
소변검사의 재검 시 세포원심분리법과 액상세포검사 $ThinPrep^{(R)}$의 효율성에 관한 비교
김현경,표주연,이윤희,정우희,김세훈,홍순원,Kim, Hyun-Kyung,Pyo, Ju-Yeon,Lee, Yoon-Hee,Jung, Woo-Hee,Kim, Se-Hoon,Hong, Soon-Won 대한세포병리학회 2007 대한세포병리학회지 Vol.18 No.1
Once diagnosed as "cell paucity"or "atypia" by the cytospin (CS) preparation, this CS preparation does not secure a precise diagnosis by repeated testing alone. Although the ThinPrep (TP) preparation is acknowledged to show increased cellularity, performing the screening tests for the cases that have enough cellularity, according to CS, raises issues for the cost-effectiveness. To obtain a more precise diagnosis through increasing the cellularity by performing TP, we selected the cases that were diagnosed as "cell paucity" or "atypia" by CS, but they required a more precise diagnosis, and the samples were processed via both CS and TP to compare the results. 11 patients diagnosed as "cell paucity" and 22 patients diagnosed as "atypia" by CS participated in this study. When the detection rate of atypical cells in both preparations with repeated urine cytology was compared, the overall detection rate of TP (16cases, 48.5%) was superior than that of CS (11cases, 33.3%), with statistical significance. The cellularity of both preparations was compared on repeated urine cytology; the general cellularity of TP (29cases, 87.9%) was higher than that of CS (20cases, 60.6%), but there was no statistical significance. Particularly, we repeated the TP for the 1 case that was diagnosed as "atypia" and we performed polyoma virus immunohistochemical staining, which confirmed polyoma virus. In conclusion, we can avoid obtaining negative diagnosis from cases with uncertain "atypia" or "cell paucity" by performing repeated TP testing.