Expression of ICAM-1 in Blood Vascular Endothelium and Tissues in Human Premalignant Lesion and Gastric/Hepatocellular Carcinomas

캉리,김문식,이유미 대한소화기학회 2022 대한소화기학회지 Vol.79 No.4

Angiogenesis is essential for the outgrowth and metastasis of tumors. The structure and characteristics of tumor vasculature differ from those of normal vessels. We compared the characteristics of differentially expressed genes in endothelial cells (ECs) isolated from gastric and normal cells. Previously, we had isolated pure tumor ECs (TECs) and normal ECs (NECs) from advanced gastric cancer (AGC) lesions and normal mucosal tissues, respectively. Using the oligomer chip platform of the Affymetrix GeneChip technology, genes that were expressed more than three-fold with a significance of p≤0.001 were measured. The intercellular adhesion molecule 1 (ICAM-1) was found to be overexpressed in the TECs compared to the normal gastric ECs. In this study, the upregulation of ICAM-1 was confirmed in cultured TECs by immunofluorescence. The expression of ICAM-1 was upregulated in the ECs, as well as in the stromal and immune cells, in early human gastric preneoplastic and hepatic fibrotic tissues. Upregulation of ICAM-1 was observed in the TECs, immune cells, and cancer epithelial cells in AGC and hepatocellular carcinoma (HCC). These results suggest that increased ICAM-1 expression in the ECs of the tissue microenvironment progressively contributes to the recruitment of immune cells to promote inflammation, leading to fibrosis and tumorigenesis. Therefore, upregulated ICAM-1 in the tissues in premalignant gastric diseases or hepatic fibrosis and their malignant cancers could be a promising target for disease prevention and treatment.

다문화 청소년의 소수언어 구사수준: 이중문화 수용태도, 부모의 교육적 지원, 부모-자녀 간 소수언어 사용도의 영향

캉리,최나야,강소연,Kang, Li,Choi, Naya,Kang, Soyeon 대한가정학회 2021 Human Ecology Research(HER) Vol.59 No.4

This study aimed to investigate the factors that influence multicultural adolescents' proficiency in their mother's native language, or their immigrant mother's native language. A hierarchical regression analysis was performed on data from the survey answered by 1,028 multicultural adolescents aged 15 years old and whose mothers were from foreign countries for the 6th Multicultural Adolescents Panel Study(MAPS) conducted by the National Youth Policy Institute (NYPI) in 2016. The main results are as follows. First, multicultural adolescents' minority language proficiency was generally low and significant differences were observed according to their gender, parents' educational level, household income, and mother's native country. More specifically, a higher proficiency in minority language was found for girls than boys, adolescents with a higher parental educational level, adolescents with a higher income, and adolescents whose mothers were from Japan or China, compared with those from the Philippines, Thailand, or Vietnam. Second, a significant positive correlation was observed between multicultural adolescents' minority language proficiency and 1) foreign culture acceptance, 2) parent's educational support, and 3) the use of the minority language at home. Third, foreign culture acceptance, parents' educational support, and the use of the minority language at home were predictors of multicultural adolescents' minority language proficiency. The study is meaningful in that it examined multicultural adolescents' minority language proficiency, elucidating their bilingual development, whereas previous studies have only focused on their proficiency in Korean, which is the majority language.

다문화 청소년의 소수언어 구사수준: 이중문화 수용태도, 부모의 교육적 지원, 부모-자녀 간 소수언어 사용도의 영향

캉리 ( Li Kang ),최나야 ( Naya Choi ),강소연 ( Soyeon Kang ) 대한가정학회 2021 Human Ecology Research(HER) Vol.59 No.4

This study aimed to investigate the factors that influence multicultural adolescents’ proficiency in their mother’s native language, or their immigrant mother’s native language. A hierarchical regression analysis was performed on data from the survey answered by 1,028 multicultural adolescents aged 15 years old and whose mothers were from foreign countries for the 6th Multicultural Adolescents Panel Study(MAPS) conducted by the National Youth Policy Institute (NYPI) in 2016. The main results are as follows. First, multicultural adolescents’ minority language proficiency was generally low and significant differences were observed according to their gender, parents’ educational level, household income, and mother’s native country. More specifically, a higher proficiency in minority language was found for girls than boys, adolescents with a higher parental educational level, adolescents with a higher income, and adolescents whose mothers were from Japan or China, compared with those from the Philippines, Thailand, or Vietnam. Second, a significant positive correlation was observed between multicultural adolescents’ minority language proficiency and 1) foreign culture acceptance, 2) parent’s educational support, and 3) the use of the minority language at home. Third, foreign culture acceptance, parents’ educational support, and the use of the minority language at home were predictors of multicultural adolescents’ minority language proficiency. The study is meaningful in that it examined multicultural adolescents’ minority language proficiency, elucidating their bilingual development, whereas previous studies have only focused on their proficiency in Korean, which is the majority language.

중국 조선족 부모의 이중언어사용과 가정문해환경이 만 3세 유아의 이중언어 표현어휘력에 미치는 영향

곽미언,최나야,캉리 미래유아교육학회 2022 미래유아교육학회지 Vol.29 No.2

This study aimed at investigating the effects of bilingual language use of parents and home literacy environment on simultaneous bilingual preschoolers’ Korean-Chinese expressive vocabulary proficiency. A total of 126 children and their parents, who were Korean ethnics living in Tumen City and Meihekou City of China, participated in this research. Bilingual expressive vocabulary task was conducted to children and parents were required to complete questionnaires about their bilingual language use and home literacy environment. Collected data were analyzed using SPSS program to compute percentiles, means, standard deviations, and to conduct Pearson’s correlation, one-way ANOVA, and regression. The main results were as follows. First, preschoolers were found to score higher in Chinese than in Korean. Though the equivalent age was relatively lower than the actual age on both languages, Korean and Chinese vocabularies were complementary to each other. Second, Korean-Chinese parents used more Chinese than Korean at home. Additionally, this unbalanced bilingual language use had a significant effect on their children’s bilingual expressive vocabulary proficiency. Third, the home literacy environment, such as the amount of books, frequency of literacy activities, and parent-child literacy activities, played an important role in improving children’s bilingual expressive vocabulary proficiency. Considering there was rare study targeting at Korean-Chinese simultaneous bilingual young children, this study focused on these subjects and examined the effect of family factors on bilingual vocabulary development, through which clarifying the importance of bilingual exposure via parents. 본 연구의 목적은 부모의 이중언어사용과 가정문해환경이 동시적 이중언어 유아의 한국어-중국어 표현어휘력에 영향을 미치는지 살펴보는 것이다. 이를 위해 중국 연변 조선족 자치주의 만 3세 유아 126명과 그들의 부모를 대상으로 자료를 수집하였다. 유아에게 두 언어의 표현어휘력 검사를 일대일로 실시하였고, 부모를 대상으로 가정 내 언어사용과 문해환경에 대한 질문지 조사를 수행하였다. 본 연구의 결과는 다음과 같다. 첫째, 한-중 동시적 이중언어 유아들은 한국어보다 중국어 표현어휘력이 더 높은 수준이고, 두 언어에 대해 모두 실제 월령보다 등가연령이 상대적으로 낮았지만, 한국어-중국어 어휘력이 상호보완적임을 알 수 있었다. 둘째, 중국 조선족 부모들은 가정에서 한국어에 비해 중국어를 더 많이 사용하고, 이러한 부모의 이중언어사용은 자녀의 이중언어 표현어휘력에 유의한 영향을 미쳤다. 셋째, 문해자료 구비정도, 문해활동 빈도, 부모-자녀 간 문해활동이 포함된 가정문해환경은 유아의 이중언어 표현어휘력 향상에 중요한 역할을 한다. 지금까지 선행연구가 매우 부족한 한국어-중국어 동시적 이중언어 습득 유아를 대상으로 한 이 연구는 이중언어 어휘력 발달에 영향을 미치는 가정적 변인에 주목함으로써 부모를 통한 두 언어 노출의 의미를 규명하였다는 의의를 가진다.