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RISS 인기검색어
- 검색키워드
- 저자 : 추한나 ( Han-na Choo ) (검색결과 3 건)
- 무료
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쪽 니람의 DNCB 유발 생쥐의 아토피 피부염에 미치는 효과
추한나,박은혜,정종길,백윤웅,김정상,Choo, Han-Na,Park, Eun-Hye,Jeong, Jong-Kil,Paek, Yun-Woong,Kim, Jeong-Sang 대한한의학방제학회 2014 大韓韓醫學方劑學會誌 Vol.22 No.1
Objectives : The purpose of this study was to investigate the effects of Polygonum tinctoria Niram(PTN) on atopic dermatitis(AD) in hairless mice induced by 2,4-dinitrochlorobenzene(DNCB). Method : They were divided into four group, Nor, Con, 1X and 5X, for evaluating the change of appearance of skin surface, skin hydration, thickness of epidermis and mast cell numbers during 30 days. Results : PTN suppressed symptoms of AD in appearance of skin and increased skin hydration for 1X and 5X. In histopathological examination, 1X and 5X significantly reduced the thickness of epidermis and number of mast cell in dermis. These results suggested that the PTN improved the AD-like symptoms of hairless Mice.
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추한나 ( Han-na Choo ),이숭인 ( Soong-in Lee ),김정상 ( Jeong-sang Kim ),정종길 ( Jong-kil Jeong ) 대한본초학회 2015 大韓本草學會誌 Vol.30 No.4
Objectives: Clerodendron trichotomum Thunberg grows wild fields and mountains in South Korea and China. They have been used for anti-hypertension disease. This study was performed in order to observe the effects of Clerodendron trichotomum Thunberg tea on anti-hypertension. Methods: For the study of Clerodendron trichotomum Thunberg tea, we had divided male SHR (Spontaneously Hypertensive Rat) to ten groups. Control group is SHR. The treatment group is SHR which is administered tea extract at dose of 200 mg/kg/day and 500 mg/kg/day orally for 8 weeks. We measured systolic blood pressure, diastolic blood pressure, number of pulse, body weight, total cholesterol and triglyceride from blood serum. Results: The level of systolic and diastolic blood pressure were significantly decreased by 12.5% and 44.9% in Clerodendron trichotomum Thunberg tea groups than control group. Heart rate of Clerodendron trichotomum Thunberg tea groups, 24.5%, was significantly lower than control group. We found that treatment with the water extract from Clerodendron trichotomum Thunberg leave and flower significantly decreased weight of body, total cholesterol and triglyceride to 20.4% and 27.7% compared to untreated control group, significantly ( P< 0.05). Conclusions: These results suggest that leaf and flower tea of Clerodendron trichotomum Thunberg tea is effective in prevention and treatment of hypertension and decreasing cholesterol. Long term consumption of Clerodendron trichotomum Thunberg leaf and flower tea can be help in lowering high systolic and blood diastolic pressure, heart rate and blood serum in SHR.
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천마 추출액이 Scopolamine으로 유발된 기억력 감퇴 흰쥐에 미치는 영향
김진호(Jin-Ho Kim),추한나(Han-na Choo),박은혜(Eun-hye Park),정종길(Jong-Kil Jeong),김경옥(Kyeong-Ok Kim),김정상(Jeong-Sang Kim) 한국식품영양과학회 2013 한국식품영양과학회지 Vol.42 No.4
알츠하이머병은 신경세포가 점차적으로 퇴화되는 질환으로 특히 해마와 기저쪽 앞뇌의 뇌조직이 위축되어 점진적으로 기억력을 잃어간다. 본 연구는 scopolamine(1 mg/kg, 7일 동안 1일 1회)으로 유발된 수컷 Sprague-Dawley 흰쥐 해마의 신경독성에 대한 천마 물 추출액의 효과를 규명하기 위하여 수행하였다. 실험동물(n=25)은 5군으로 나누었으며, 각 군마다 5마리씩 사용하였다. 실험군은 생리식염수를 투여한 정상군(Nor), scopolamine으로 유발한 다음 생리식염수를 20일(C-20)과 30일(C-30) 동안 투여한 대조군, scopolamine으로 유발한 다음 천마 추출액(200 mg/kg)을 20일(G-20)과 30일(G-30) 동안 투여한 실험군으로 구분하였다. 광학현미경으로 관찰한 결과 해마의 신경세포 핵은 G-20과 G-30에 비하여 C-20과 C-30에서 보다 응축되었거나 위축되어 있었다. 해마의 CA1과 CA3의 세포밀도를 조사한 결과 실험군이 대조군보다 높게 나타났다. 해마 주변의 뇌세포를 PAS로 염색한 결과 amyloid β 단백질을 함유한 PAS-양성물질이 대조군에 비하여 실험군에서 감소하였다. 이상의 결과로 보아 천마 물추출액은 scopolamine으로 유발된 신경 독성을 개선하는 효과가 있는 것으로 사료되었다. Alzheimer"s disease is a progressive neurodegenerative disorder characterized by a gradual decline in memory associated with shrinkage of brain tissue, with a localized loss of neurons mainly in the hippocampus and basal forebrain. This study investigated the neuroprotective effect of Gastrodia elata aqueous extracts against scopolamine- induced neurotoxicity in the hippocampus of male Sprague-Dawley rats. The animals (n=25) were divided into five different groups with five animals per each group. The normal group (Nor) was administered with saline, while the control (Con) group was administered saline after scopolamine treatment. The experimental group (Exp) was administered Gastrodia elata aqueous extracts (200 mg/kg body weight) for 20 or 30 days after scopolamine treatment. From a light microscopy study, the nuclei of neurons in the hippocampus were more shrunken or condensed in the 20 or 30 day control groups compared to experimental groups. The densities of neurons from the CA1 and CA3 area of the hippocampus in the Exp increased compared with the Con. Amyloid β protein, containing PAS-positive materials, was lower in the Exp compared with the Con. The present study demonstrates that Gastrodia elata aqueous extracts possess neuroprotective potential, thus validating its use in alleviating the toxic effects of scopolamine.
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