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α2A-, α2B-, α2C-아드레날린 수용체 유전자 다형성과 대뇌 백색질변성과의 연관성
김미화,안세아,이한빈,추승욱,김남근,김원찬,김옥준,오승헌 대한뇌졸중학회 2011 Journal of stroke Vol.13 No.2
Background: An α2-adrenergic receptor (α2-AR, ADRA2) mediates induction of hypotension and inhibition of lipolysis and insulin secretion. We evaluated whether single nucleotide polymorphisms (SNPs) of α2A (ADRA2A), α2B (ADRA2B), and α2C (ADRA2C)adrenergic receptors are associated with cerebral white matter lesion (cWML). Methods: Total 336 study subjects who had no stroke were enrolled in this study. The Indices of cWML include total WML (TWML), periventricular WML(PVWML), and subcortical WML (SCWML) on brain fl uid-attenuated inversion recovery (FLAIR) image. Common genetic variants of ADRA2A (1780G>A), ADRA2B (Ins/Del301-303), and ADRA2C (Ins/Del322-325) were examined. Results: Among 336 study subjects, cWML was found in 66 patients (20%). In multivariate analysis, there were no signifi cant effects of all tested ADRA2 polymorphisms on TWML. Signifi cant association of ADRA2A 1780 AA genotype was found in PVWML(OR: 3.368, 95% CIs: 1.280-8.865, adjusted p-value after false discovery rate (FDR) correction=0.014) but not SCWML. Conclusion: Although SNPs of three ADRA2 subtypes failed to reach a signifi cance in overall risk for cWML, the ADRA2A 1780G>A polymorphism may be associated with development of PVWML. (Korean J Stroke 2011;13:66-73)
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최정원,이기욱,장예지,김현경,서태호,노유정,추승욱,오승헌 연세대학교의과대학 2023 Yonsei medical journal Vol.64 No.1
Purpose: The mean platelet volume (MPV) is regarded as a marker for thrombosis, atherosclerosis, and inflammation in various vascular diseases. However, it still remains unclear whether plasma MPV is associated with cerebral white matter hyperintensities (WMH) and cerebral microvascular pathology in the elderly population. Materials and Methods: We examined whether MPV level is associated with the presence of cerebral WMH on brain magnetic resonance imaging from 870 non-stroke outpatient subjects. The subjects were divided into three groups according to the consecu tive level of MPV (low T1, middle T2, and high T3 MPV tertile groups). To determine the association of MPV levels with the WMH, logistic regression and receiver operating characteristic curve analyses were conducted. Results: Subjects with higher MPV level were older and more likely to have hypertension, diabetes mellitus, and low renal func tion. Cerebral WMH were more prevalent in subjects with higher MPV level. After adjusting for confounding factors, moderate to severe cerebral WMH were significantly associated with high MPV tertile level. This association remained significant after adjust ing for other cerebral vascular pathologies. T2 [odds ratio (OR): 1.49, 95% confidence interval (CI): 1.03–2.15] and T3 MPV tertile groups (OR: 1.51, 95%CI: 1.04–2.20) had more cerebral WMH lesions compared to T1 MPV tertile group. In addition, the subjects with higher Fazekas scores showed higher MPV level (p=0.020). Conclusion: We found that high MPV level is independently associated with cerebral WMH. This result suggests that platelet acti vation plays a role in the development of cerebral WMH.
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