http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
2-Chloro-2-(methylthio)acetophenone을 이용한 2-페닐벤조[b]퓨란 유도체의 합성
崔洪大,徐弼子,孫炳華 동의대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.10 No.1
It is well known that 2-arylbenzo[b]furan derivatives are occured in natural products such as Styrax obassia, Sophora tomentosa, and Krameria ramosissima. In the course of our search on the carbon-carbon bond formation utilizing 1-acyl-l-thiocarbocationic intermediates, we showed that the reaction of substituted phenols with α-chloro-α-(methylthio)acetone (1) in the presence of Lewis acid provided a convenient method for the 2-methylbenzo[b]furans (3) through the reductive desulfurization of the resulting products (2) (Scheme 1). The present paper describes the one-step synthesis for 2-phenylbenzo[b]furan derivatives from the reaction of phenol or cresol isomers with 2-chloro-2-(methylthio) acetophenone in the presence of zinc chloride. Many procedures have been reported for the preparation of 2-phenylbenzofuran ring. Among them, the most frequently employed method is based upon the cyclodehydration reaction of aryloxyacetone moiety with standard dehydrating reagents(H₂SO₄, ZnCl₂, POCl₃, KOH or PPA).
崔洪大,徐弼子,孫炳華 동의대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.10 No.1
황원자가 α-탄소상의 양이온을 안정화시키는 성질을 가짐은 널리 보고되어있다. 이 α-thiocarbocations를 이용한 탄소-탄소결합형성반응에 관한 연구의 일환으로서, 저자동은 Scheme 1처럼 Friedel-Crafts반응 또는 Pummerer반응조건하에서 발생되어지는 황원자와 acyl기(nitrile기를 포함)에 인접한 탄소양이온(1-acyⅠ-1-thiocarbocations)과 방향족 화합물로부터 arylacctic acid와 arylacetone 및 arylacetonitrile의 간편한 합성법을 개발하였다. 또한 1-acyⅠ-1-thiocarbocations를 적용하여 phenylacetic acid의 모핵구조를 포함하는 소염제인 aryalkanoic acid의 제법을 보고하였다.
최홍대,조용잔,손병화,정동윤,박종희 동의대학교 기초과학연구소 1999 基礎科學硏究論文集 Vol.9 No.1
Two isoflavonoids were isolated from the flows of Pueraria lobata (Flos puerariae) guided initially fractionation based on brine shrimp lethality assay. The structures were identified as 4',5,7-trihydroxy-6-methoxyisoflavone (tectorigenin) and 4',7-dihydroxy-6-methoxyisoflavone (glycitein), respectively, on the basis of their spectroscopic and physicochemical evidences.
메틸 2-클로로-2-(메틸티오)아세트산을 이용한 치환페놀류로부터 2(3H)-벤조푸란온 유도체의 합성
최홍대,김미헌,신상훈,손병화 동의대학교 기초과학연구소 1997 基礎科學硏究論文集 Vol.7 No.1
5-Alkyl-2(3H)-benzofuranones(3a-e) were prepared from Friedel-Crafts reaction of 4-alkyl-phenols with methyl 2-chloro-2-(methylthio)acetate(1) followed by the treatment of zinc dust-acetic acid. The reaction of disubstituted phenols with 1 in the presence of stannic chloride afforded 3-methylthio-2(3H)-benzofuranone derivatives(11a-c), which were readily converted into 2(3H)-benzofuranone derivatives(12a-c) by desulfurization with zinc dust-acetic acid.
항염증제로서 2-아릴-5-벤즈옥사졸프로피온산 유도체의 합성
최홍대,곽용실,금덕현,손병화 동의대학교 기초과학연구소 1995 基礎科學硏究論文集 Vol.5 No.1
A facile synthesis of 2-aryl-5-benzoxazolepropionic acid derivatives(10a-d), which are potent antiinflammatory agent, is reported. Methyl α-(p-hydroxyphenyl)propionate(5) was prepared from Froedel-Crafts reaction of isopropoxy benzene with methyl α-chloro-α(methylthio) acetate(1), followed by desulfurization, methylation and clevage of ether bond. Compounds(10a-d) were made from(5) by sequence of nitration, reduction, formation of benzoxazole ring, and hydrolysis in good yields, respectively.
최홍대,강병원,마정주,윤호상,손병화 동의대학교 기초과학연구소 1993 基礎科學硏究論文集 Vol.3 No.1
A new method for the synthesis of alminoprofen, which is a non-steroidal antiinflammatory agent, was described. Ethyl 2-phenyl-propionate(4) was prepared by Friedel-Crafts reaction of benzene with ethyl α-chloro-α-methylthio)acetate(1), followed by methylation and desulfurization of the resultant ethyl 2-(methylthio)phenylacetate(2). Ethyl 2-(p-aminophenyl)propionate(6) was obtained by nitration of (4) and successive reduction of ethyl 2-(p-nitrophenyl)propionate(5). Alminoprofen was synthesized by reaction of (6) with methallyl chloride, followed by hydrolysis of the resultant ethyl 2-(p-methylallylaminophenyl)propionate (7).