방추형 추골 동맥류 혈전증에 의한 일시적 외측 연수 허혈 -증례 보고-

최하철,임형석,오선영,신병수 대한중환자의학회 2012 Acute and Critical Care Vol.27 No.1

The frequency of vertebral artery aneurysm is rare and a common presenting sign is subarachnoid hemorrhage. Lateral medullary syndrome is characterized by loss of pain and temperature sensation on the contra lateral lesion side of the body and ipsilateral lesion side of the face, dysphagia, dysarthria, ataxia, vertigo, nystagmus, and Horner syndrome. Vertebral artery dissecting aneurysm is a common cause of lateral medullary infarction. We present a rare case of a 46-year old male patient that developed ischemic attack presenting as transient lateral medullary syndrome due to thrombosed-fusiform aneurysm of vertebral artery. He was treated with aspirin and heparin, and then discharged with complete resolution of symptoms.

메트로니다졸에 의한 가역성 소뇌병증

최하철,신병수,서만욱,김영현,오선영 대한평형의학회 2009 Research in Vestibular Science Vol.8 No.2

Metronidazole is a nitroimidazole antibiotic used for anaerobic infections, protozoan infections, and Helicobacter pylori infections. It may produce rare but well known neurological adverse effects including peripheral neuropathy, encephalopathy, cerebellar dysfunction, and seizures. We describe three patients with metronidazole-induced reversible cerebellar dysfunctions characterized by abnormal oculomotor findings, dysmetria, and ataxia. The diagnosis of metronidazole toxicity was made clinically and supported by the brain MRI findings. The neurological signs and abnormal signal intensity on MRI resolved after discontinuation of metronidazole. Metronidazole is a nitroimidazole antibiotic used for anaerobic infections, protozoan infections, and Helicobacter pylori infections. It may produce rare but well known neurological adverse effects including peripheral neuropathy, encephalopathy, cerebellar dysfunction, and seizures. We describe three patients with metronidazole-induced reversible cerebellar dysfunctions characterized by abnormal oculomotor findings, dysmetria, and ataxia. The diagnosis of metronidazole toxicity was made clinically and supported by the brain MRI findings. The neurological signs and abnormal signal intensity on MRI resolved after discontinuation of metronidazole.

기질성 정신장애환자와 정상노인의 인식기능에 관한 연구

신석철,최하석 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.2

This study was designed to examine cognitive function between organic mental disorder(OMD) patients and normal edlerly. First, the authors selected 41 OMD patients and 38 normal elderly, and then performed CAMCOG(Cognitive examination of CAMDEX) to them. Second, the authors selected not-different CAMCOG items between the two groups, and using SPSS/PC' performed factor analysis. The results were summarized as follows. 1. Seven factors were found out by factor analysis, and total variance of these factors were 64.1%. 2. Factor 1 was Praxis and Reading comprehension, Factor 2 was Language comprehension, Factor 3 was Unknown factor, Factor 4 was Language comprehension and expression, Factor 5 was Response to language, and Factor 6 was Expression of definitions. 3. Factor 1 was the most important factor, with eigen value 2.45, variance 17.5.

희귀한 대장게실증 2례

신병철,김경일,최철호,이상훈,전명호,이상기,이찬세,최하진 인제대학교 1991 仁濟醫學 Vol.12 No.2

우리나라에 있어서 대장게실의 발생빈도는 서양에 비하면 아주 적고 특히 다발성 대장게실의 경우는 아주 희귀하므로 중례보고하는 바이다. It has been usually believed that diverticular disease of the colon were more frequent in western countries than in Asia and in Korea. It was formerly considered to be rare, but according to recent Korean literatures, the incidence of colon diverticulums found on the barium enema studies were salts to be not so rare and the rates ranged between 0.33% (our own experince out of 1800 exams) to 11.8%. However, the following cases we report here were thought to be very rare in any literatures as far as we have known. The first case we experinced was a 37 years old male patient with multiple cecal diverticulosis visible on the films and the next one was 41 years old male patient with numerous widely distributed down to sigmoid colon. They were diagnosed on routine exam for nonspecific gastrointestinal symptoms, that is irregular frequent abdominal pains and frequent diarrheas after some alcoholic drinks. Their daily diets were usual Korean food stuffs with large amount of vegetable fibers. As for the developmental mechanism of above two cases were thought to be due to congenital malformation rather than acquired relating to the diet or intestinal Internal pressures, because of their location and multiplicites.

양극성 기분장애에서 세로토닌 수용체 유전자의 다형성(102T/C)에 관하여

지익성,신석철,왕성근,이선우,신용재,김충수,김상국,최하석,오승용,류택근,이영호 대한생물치료정신의학회 1999 생물치료정신의학 Vol.5 No.2

Optimization of Large-Scale Expansion and Cryopreservation of Human Natural Killer Cells for Anti-Tumor Therapy

민보경,최하나,허정현,정미영,김효진,정미영,이은경,조성유,황유경,신의철 대한면역학회 2018 Immune Network Vol.18 No.4

Allogeneic natural killer (NK) cell therapy is a potential therapeutic approach for a variety of solid tumors. We established an expansion method for large-scale production of highly purified and functionally active NK cells, as well as a freezing medium for the expanded NK cells. In the present study, we assessed the effect of cryopreservation on the expanded NK cells in regards to viability, phenotype, and anti-tumor activity. NK cells were enormously expanded (about 15,000-fold expansion) with high viability and purity by stimulating CD3+ T cell-depleted peripheral blood mononuclear cells (PBMCs) with irradiated autologous PBMCs in the presence of IL-2 and OKT3 for 3 weeks. Cell viability was slightly reduced after freezing and thawing, but cytotoxicity and cytokine secretion were not significantly different. In a xenograft mouse model of hepatocellular carcinoma cells, cryopreserved NK cells had slightly lower anti-tumor efficacy than freshly expanded NK cells, but this was overcome by a 2-fold increased dose of cryopreserved NK cells. In vivo antibody-dependent cell cytotoxicity (ADCC) activity of cryopreserved NK cells was also demonstrated in a SCID mouse model injected with Raji cells with rituximab co-administration. Therefore, we demonstrated that expanded/frozen NK cells maintain viability, phenotype, and anti-tumor activity immediately after thawing, indicating that expanded/frozen NK cells can provide ‘ready-to-use’ cell therapy for cancer patients.

소뇌증상으로 발현한 중심교뇌수초용해증

김의중,오선영,최하철,신병수,임미혜 대한신경과학회 2009 대한신경과학회지 Vol.27 No.3

Central pontine myelinolysis (CPM) is a neurologic disorder that is usually related to rapid correction of hyponatremia and chronic alcoholism. CPM involves concentrated, symmetric, noninflammatory demyelination within the central pons; this pathology also occurs in extrapontine regions. Frequently observed clinical manifestations are sudden weakness, dysphagia, dysarthria, loss of consciousness, and locked-in syndrome. We describe herein a case of CPM predominated by cerebellar signs without typical symptoms, but with involvement of the cerebellum or cerebellar peduncle. Central pontine myelinolysis (CPM) is a neurologic disorder that is usually related to rapid correction of hyponatremia and chronic alcoholism. CPM involves concentrated, symmetric, noninflammatory demyelination within the central pons; this pathology also occurs in extrapontine regions. Frequently observed clinical manifestations are sudden weakness, dysphagia, dysarthria, loss of consciousness, and locked-in syndrome. We describe herein a case of CPM predominated by cerebellar signs without typical symptoms, but with involvement of the cerebellum or cerebellar peduncle.

상부 공장의 평활근종 2례

채창식,이성근,이재윤,서정철,이상혁,설상영,정정명,최하진 인제대학교 1993 仁濟醫學 Vol.14 No.1

저자들은 장출혈과 급성 빈혈을 동반한 상부 공장의 평활근종 2례를 경험하고 문헌고찰과 함께 이를 보고하는 바이다. The small bowel tumors are often very difficult to confirm, and in many cases, these tumors are incidentally found during exploratory laparotomy. Sometimes, these tumors cause unexplained abdominal pain, intestinal obstruction, or intestinal hemorrhage, which leads to emergency surgical intervention with relatively high mortality. We report 2 cases of upper-jejunal leiomyoma with intestinal hemorrhage experienced in Inje University Pusan Paik Hospital in December, 1990 and January, 1991 with brief review of the cases.

위장관 ( 胃腸管 ) : Campylobacter Pylori와 Carcinogen의 투여에 의한 Mouse의 위점막 변화

정정명(Jung Myung Chung),최하진(Ha Jin Choi),김동수(Dong Soo Kim),설상영(Sang Young Seol),서정철(Jeong Cheol Seo),채창식(Chang Sik Chai) 대한소화기학회 1991 대한소화기학회지 Vol.23 No.1

N/A Although it has long been assumed tht the infection of pathogenic bacteria within stomach may cause various kinds of gastric diseases, little interest has been really taken because of a previous inability to isolate the organism. However, after a campylobacter-like organism was first isolated in 1983 and is named campylobacter pylori, the association between the infection of campylobacter pylori and the various kinds of gastritis was investigated at a lot of clinics. It seems to be that campylobacter pylori played a important role in the etiology of chronic gastritis or peptic ulcer diseases. But there is limited evidence to suggest such a role. In order to find out how campylobacter pylori affects gastric mucosa, we made an oral administration of campylobacter pylori only, MNNG only, and both of campylobacter pylori and MNNG at the same time to the experimental mice and observed the changes to gastric mucosa in each mice group at periods. The following results were obtained 1) The change of gastric mucosa of the mice that had the administration of only campylobacter pylori: In the three-month group, all the five mice showed inflammatory change in antrum of the stomach but only one mouse showed inflammatory change in body of the stomach and in the six-month group, all the five mice showed inflammatory change in antrum and three of them showed inflammatory change in body of the stomach. 2) The change of gastric mucosa of the mice that had the administration of only MNNG: In the six-month group, two of five mice showed gracie A mucosal abnormality and in the nine-month group, four of seven mice showed grade A and three of seven mice showed grade B abnormality. 3) The change of gastric mucosa of the mice that had the administration of both campylobacter pylori and MNNG at the same time: In the six-month group, two of four mice showed grade A mucosal abnormality and in the nine-month group, two of six mice showed grade B and four of six mice showed grade C mucosal abnormality. But in none of them occurred cancer. From these results, it could be suggested that the campylobacter pylori causes the mucosal changes in the stomach antrum and that, in the longterm infection, this inflammation could progress to the body of the stomach. And also, in the administration of both of campylobacter pylori and carcinogen at the same time, there is high possibility of promoting the development of stomach cancer. Of course, this subject needs a lot of further researches hereafter.

OADM을 포함한 2.5Gbps x 16채널 WDM 장거리 전송시스템 구현

이강호(Ghang-Ho Lee),조주철(Ju-Cheol Cho),김병훈(Byeong-Hoon Kim),최하순(Ha-Sun Choi),심창섭(Chang-Sup Shim) 한국통신학회 1999 한국통신학회 학술대회논문집 Vol.1999 No.7