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효모에서 분리한 멜라닌 생성 억제 물질의 세포분화 억제
최태부 ( Taeboo Choe ),이승선 ( Seungsun Lee ),정호권 ( Hokwon Jung ),오철 ( Oh Chul ) 대한화장품학회 2005 대한화장품학회지 Vol.31 No.1
본 연구에서는 효모에서 분리한 melanoston이라고 명명된 멜라닌 생성을 억제하는 물질의 작용 기전을 밝히기 위한 것이다. α-MSH를 처리한 B16 melanoma 세포에서 melanoston은 tyrosinase mRNA 발현양을 10% 정도 저해되는데 그쳤으며 western blotting을 이용한 단백질 측정에서도 이와 비슷한 정도의 단백질 생성 억제를 보였다. 그러나 B16 세포 배양액에 melanoston을 첨가할 경우 세포내 tyrosinase 활성이 30%까지 감소되는 것으로 나타나 melanoston이 tyrosinase inhibitor는 아니지만 세포내 tyrosinase 활성화(activation) 과정을 억제하는 것으로 추측할 수 있었다. 또한 광학 현미경을 이용한 morphology 관찰에서 α-MSH를 처리한 세포에서는 많은 dentrite가 형성되면서 세포분화가 일어나는 반면 melanoston를 처리한 경우에는 dendrite가 감소하면서 세포형태가 대조군과 비슷하게 회복되는 것을 알 수 있었다. 또 FITC-anti-tyrosinase-Ab를 이용한 형광염색을 통해서는 α-MSH만 처리한 세포에서는 tyrosinase의 분포가 dendrite를 포함한 세포 전체로 퍼져나가는 것을 관찰 할 수 있었고 α-MSH와 melanoston을 동시에 처리한 세포에서는 대조군과 비슷하게 tyrosinase가 핵 주변에서만 관찰되어 melanoston이 B16 melanoma 세포의 분화과정에서 이를 억제하는 효과를 주고 있음을 알 수 있었다. 이상의 결과들을 종합해 볼 때 melanoston은 α-MSH에 의해 진행되는 B16 세포의 분화를 억제하고 이 과정에서 멜라닌 생성의 주된 효소인 tyrosinase의 활성화를 억제하며 결과적으로는 멜라닌 생성을 저해하는 것으로 사료된다. Melanocytes synthesize melanin within discrete organelle termed melanosomes which are transferred to the surrounding keratinocytes and can be produced in varying sizes, numbers and densities. Skin whitening products have become increasingly popular in the past few years. The most successful natural skin whitening agents are: arbutin, vitamin C, kojic acid, and mulberry, which are all tyrosinase inhibitors. In this work, melanoston, a melanogenesis inhibitor isolated from yeast was studied to understand its mechanism of melanogenesis inhibition. It was found that melanoston was not a tyrosinase inhibitor, while when melanoston was applied to the B16 melanoma cell culture media, the intracellular tyrosinase activity was decreased by more than 30%. When B16 melanoma was stimulated with α-MSH, cell morphololgy was dramatically changed to have lots of dendrites on the cell membrane surface. On the other hand, B16 was treated with α-MSH and melanoston, simultaneously, the change of cell morphologv was not so great. This inhibitory effect of melanoston was found to be related to the inhibition of intracellar activation and transportation of tyrosinase, which was observed by irmmunostaining of B16 melanoma using anti-tyrosinase antibody. From these results, melanoston was regarded as an inhibitor to the differentiation of melanoma cells.
포도(Red Glove)의 Pectinase 처리가 레드와인의 생산과 품질에 미치는 영향
이정창(Jung-Chang Lee),최용근(Yong-Keun Choi),박정수(Jung Soo Park),정희훈(Heehoon Jung),이동희(Dong-Hee Yi),최태부(Taeboo Choe),강상모(Sang-Mo Kang),김형주(Hyung Joo Kim) 동아시아식생활학회 2012 동아시아식생활학회지 Vol.22 No.2
The effect of pectinase on wine production and quality during wine fermentation was investigated in an experiment a laboratory scale (2 ㎏ grape/5 L tank). Experimental results show that the enzyme-treated sample displayed a 13% higher rate of grape juice production compared to control (enzyme-untreated). In the case of color analysis, the addition of pectinase improved the color quality of wine in terms of both color intensity and hue values. The results show that pectinase enhanced both dark-red color and clarity of wine during the fermentation period. Further, the methanol concentration of the wine sample treated with pectinase reached 225.32 ㎎/L (control: 100.72 ㎎/L) due to hydrolysis of pectin. Sensory analysis after fermentation showed that pectinase significantly increased the color, smell, taste, and touch intensity scores of wines compared to control.
천연 방부제의 항균 활성과 화장품 조성에 따른 방부력 변화
최은영,이진성,최연선,최태부 건국대학교 산업기술연구원 2006 건국기술연구논문지 Vol.31 No.-
Grapefruit Seed Extract (GSE), thyme and lemongrass oil have been well known as natural materials with its distinguished antimicrobial activities. In this study, antifungal and antimicrobial susceptibility of methyl paraben and propyl paraben, which are both synthetic and common cosmetic food grade preservatives, and also that of natural preservatives were tested. Thus, we tested preservative activity of lotion formulation with natural preservatives. From the results of the test with liquid culture medium revealed that GSE had the highest antimicrobial effect among the test resulting materials with Minimum Inhibitory Concentration (MIC) value and Minimum Bactericidal Concentration value, and that thyme and lemongrass had similar ranges of inbibitory concentration. Therefore, from the results of the test, it was confirmed that all natural materials had higher level of antimicrobial activity, and based on this test result, relevant cosmetics were made and the possibility of a preservative was tested accordingly. It was confirmed that there were antimicrobial activities which were higher than that of existing synthetic preservatives or similar to it in all formulations that contained each of GSE, thyme, and lemongrass. And it was confirmed that there were antimicrobial activities at 0.03%, 0.1%, 0.1% of samples, respectively. Also, me tested preservative activity of the mixture of essential oil, it was unable to confirm the synergic effects caused by mixture use. And it showed similar results to the antimicrobial activity of essential oil alone. In consequence, it was concluded that GSE, thyme and lemongrass oil could replace existing synthetic preservative effectively.