한국 공황장애 환자에서 COMT 및 5-HTTLPR 다형성의 연관 분석 : 재현 연구

김세웅,최태규,이상혁,Kim, Se-Woong,Choi, Tai Kiu,Lee, Sang-Hyuk 대한생물정신의학회 2016 생물정신의학 Vol.23 No.4

Objectives We investigated whether the catechol-O-methyltransferase (COMT) and serotonin related gene polymorphisms may be associated with agoraphobia in patients with panic disorder in Korea. Methods The COMT gene (rs4680), 5-hydroxytryptamine (serotonin) transporter linked polymorphic region (5-HTTLPR) gene (rs25531), serotonin receptor 1A (HTR1A) gene (rs6295) genotypes were analyzed in 406 patients with panic disorder and age-sex matched 206 healthy controls. Patients with panic disorder were dichotomized by the presence of agoraphobia. The following instruments were applied : the Beck Depression Inventory, the Beck Anxiety Inventory, the Panic Disorder Severity Scale. Results There was a significant difference in the distribution of 5-HTTLPR genotype between panic patients with agoraphobia and without agoraphobia (p = 0.024). That is, the panic patients with agoraphobia had a significant excess of the less active 5-HTTLPR allele (S allele). (p = 0.039) Also, we replicated previous western reports which indicated a significant difference in the distribution of COMT genotype between the patients with panic disorder and the healthy controls (p = 0.040). However, no significant associations of agora-phobia or panic disorder with HTR1A gene polymorphisms were found. Conclusions This result supports that the COMT polymorphisms may be associated with panic disorder and suggests that the 5-HTTLPR polymorphisms may play a role in the pathogenesis of agoraphobia in the Korean patients with panic disorder.

스마트폰중독과 정신병리 사이의 상관관계

이성재,김보라,최태규,이상혁,육기환,Lee, Sung-Jae,Kim, Borah,Choi, Tai Kiu,Lee, Sang-Hyuk,Yook, Ki-Hwan 대한생물정신의학회 2014 생물정신의학 Vol.21 No.4

Objectives This study aims to investigate possible associations between proneness toward smartphone addiction and certain psychopathological variables to evaluate the psychopathological meaning of smartphone addiction. Methods Questionnaires were assigned to 755 adults between September and November 2012. We used the Korean Smartphone Addiction Proneness Scale (SAPS), the Beck Depression Inventory (BDI), the Beck Anxiety Inventory (BAI), the Obsessive-Compulsive Inventory-Revised (OCI-R), and the Barratt Impulsivity Scale-11 (BIS-11). Subjects were classified into two groups according to the scores of the SAPS ; the addiction proneness group and the normal-user group. Results The addiction proneness group had significantly higher scores than the normal-user group in the BDI, BAI, OCI-R, and BIS-11. The scores of the SAPS were positively correlated with the scores of the BDI, BAI, OCI-R, and BIS-11. Using logistic regression analysis, smartphone addiction proneness showed a significant association with BIS-11. Conclusions The results of this study suggest that smartphone addiction proneness may be associated with depression, anxiety, obsessive-compulsive symptoms, and impulsivity. Furthermore, impulsivity could be a vulnerability marker for smartphone addiction proneness.

공황장애 환자에서 범불안장애 공존 유무에 따른 임상적 특징 비교

오종수,정슬아,최태규,Oh, Jongsoo,Jung, Sra,Choi, Tai-Kiu 대한불안의학회 2017 대한불안의학회지 Vol.13 No.1

Objective : This study aimed to investigate differences in demographic, clinical characteristics, and quality of life between panic-disorder patients with generalized anxiety disorder (PD+GAD) and without generalized anxiety disorder (PD-GAD). Methods : We examined data from 218 patients diagnosed with PD+GAD (150 patients) and PD-GAD (68patients). The following instruments were applied: Stress coping strategies, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Panic Disorder Severity Scale (PDSS), Anxiety Sensitivity Index-Revised (ASI-R), Albany Panic and Phobia Questionnaire (APPQ), NEO-neuroticism(NEO-N), Short Form health survey-36 (SF-36). Results : Compared to the PD-GAD group, the PD+GAD group had higher scores in emotion-focused coping strategies and clinical severity, such as BDI, BAI, PDSS, ASI, APPQ, and neuroticism. The PD+ GAD group showed lower scores in most scales in SF-36 status than PD-GAD group. Conclusions : This study shows that PD+GAD patients are different from PD-GAD patients in coping strategies, clinical severity and quality of life. It emphasizes the need of personalized therapy in clinical approach among patients with PD+GAD.

초발 조현병, 만성 조현병과 건강 대조군의 뇌활과 분계섬유줄 연결성 비교

이아리라,윤미림,육기환,최태규,이강수,방민지,이상혁,Lee, Arira,Yun, Mirim,Yook, Ki Hwan,Choi, Tai Kiu,Lee, Kang Soo,Bang, Minji,Lee, Sang-Hyuk 대한생물정신의학회 2019 생물정신의학 Vol.26 No.1

Objectives Disrupted integrities of the fornix and stria terminalis have been suggested in schizophrenia. However, very few studies have focused on the fornix and stria terminalis comparing first-episode schizophrenia (FESZ), chronic schizophrenia (CS), and healthy controls (HCs) with the application of diffusion-tensor imaging (DTI) technique. The objective of this study is to compare the connectivity of the fornix and stria terminalis among FESZ, CS, and HCs. Methods We included the 44 FESZ patients, 39 CS patients and 20 HCs in this study. Voxel-wise statistical analysis of the fractional anisotropy (FA) data was performed using Tract-Based Spatial Statistics to analyze the connectivity of fornix and stria terminalis. In addition, the Scale for the Assessment of Positive Symptoms (SAPS) and the Scale for the Assessment of Negative Symptoms (SANS) were used to evaluate clinical symptom severities. Results There were no significant differences between the FESZ, CS, and HCs in age, sex, education years. The SAPS and SANS scores of the schizophrenia groups showed no significant differences. FA values of the right fornix cres/stria terminalis in the CS group were significantly lower than those in FESZ and HCs. There were no significant differences of FA values of the right fornix cres/stria terminalis between the FESZ and the HCs. Pearson correlation analyses revealed that significant correlation between FA values of the right fornix cres/stria terminalies of the the FESZ group and positive, negative symptom scales, and FA values of the right fornix cres/stria terminalis of the CS group and negative symptom scales. Conclusions This study shows that FA values of the fornix and stria terminalis in the CS were lower than in the FESZ and the HCs. These results suggest that the fornix and stria terminalis can play a role in pathophysiology of schizophrenia. Thus current study can broaden our understanding of the pathophysiology of schizophrenia.

초기 성 학대 경험이 있는 여성 공황장애 환자의 임상적 특성

김경민,김민경,이강수,최태규,이상혁,Kim, Kyung Min,Kim, Min-Kyoung,Lee, Kang Soo,Choi, Tai Kiu,Lee, Sang-Hyuk 대한생물정신의학회 2016 생물정신의학 Vol.23 No.4

Objectives The objective of this study is to investigate differences of clinical characteristics between a healthy female control group and female panic disorder (PD) patients with early sexual abuse history (PD+S) and without early sexual abuse history (PD-S). Methods We examined data from 83 patients diagnosed with PD and 20 healthy control subjects. We divided the patients with PD into PD+S (32 patients) and PD-S (51 patients) to compare demographic and clinical characteristics. The following instruments were applied: the Stress coping strategies, the Beck Depression Inventory (BDI), the Panic Disorder Severity Scale, the Anxiety Sensitivity Index-Revised (ASI-R), the Albany Panic and Phobia Questionnaire (APPQ) and the NEO-neuroticism. Results Compared to the PD-S, the PD+S group showed higher scores in neuroticism and the APPQ. And, in the PD+S group, the scores of neuroticism were correlated with the ASI-R and APPQ subscale scores and the APPQ total scores were associated with the scores of BDI. Conclusions This study shows that female PD+S patients have higher scores in neuroticism and the APPQ than the PD-S group, and these factors are associated with the panic-related symptoms severity. It emphasizes the need of specific strategies considering the childhood abuse history such as early sexual abuse in clinical approach among patients with PD.

유산 경험이 있는 여성 공황장애 환자의 임상적 특성

황혜진,오종수,방민지,원은수,이강수,최태규,이상혁,Hwang, Hye Jin,Oh, Jongsoo,Bang, Minji,Won, Eunsoo,Lee, Kang Soo,Choi, Tai Kiu,Lee, Sang-Hyuk 대한생물정신의학회 2019 생물정신의학 Vol.26 No.2

Objectives The objective of this study is to investigate differences in clinical characteristics between female panic disorder (PD) patients with abortion history (PD+A) and without abortion history (PD-A). Methods We examined data from 341 female patients diagnosed with PD. We divided the patients with PD into PD+A (82 patients) and PD-A (259 patients) to compare demographic and clinical characteristics. The following instruments were applied : stress coping strategies, NEO-neuroticism, the Anxiety Sensitivity Index-Revised (ASI-R), the Albany Panic and Phobia Questionnaire (APPQ), the Beck Depression Inventory, the Beck Anxiety Inventory (BAI) and the Sheehan Disability Scale. Results Compared to the PD-A, the PD+A group showed no significant difference in coping strategies. However, significantly higher scores in neuroticism, the ASI-R, the APPQ and the BAI were observed. In terms of health-related disability, the PD+A group did not show significant difference. Conclusions Our results suggest that the PD+A group may differ from the PD-A group in trait markers such as neuroticism and anxiety sensitivity, and abortion history may be associated with panic-related symptom severity. Our study suggests that further consideration is needed on such clinical characteristics in PD patients with abortion history.

초등학생의 주의력결핍과잉행동 증상과 인터넷 중독 경향성, 우울, 불안 증상의 관련성

유 미(Mi Lyu),김근향(Keun-Hyang Kim),홍현주(Hyun Ju Hong),최태규(Tai-kiu Choi),육기환(Ki-Hwan Yook) 한국중독정신의학회 2010 중독정신의학 Vol.14 No.1

Objectives:This study aimed to evaluate the relationship between Attention-Deficit/Hyperactivity Symptoms and Internet Addiction, Depression, and Anxiety in Elementary-school Students. Methods:Participants were 477 children, ranging from the 4th to the 6th grade in elementary school and their parents. The participants completed the following measures; the Korean version of the parent ADHD Rating Scale (K-ARS), the Korean version of the Conners Parent Rating Scale (K-CPRS), the Korean version of the Child Behavior Checklist (K-CBCL), the Young’s Internet Addiction Test (IAT), the Children’s Depression inventory (CDI), and the Revised Children’s Manifest Anxiety Scale (RCMAS). Results:ADHD symptoms, depression, and anxiety symptoms were significantly related to Internet addiction severity. After we controlled for the effects of sex, depression, and anxiety symptoms, ADHD symptoms predicted Internet addiction severity, as parent-reported and as child-reported. However, there were some differences between parent-report scale scores and child-report scale scores. In the parent reports, ADHD symptoms correlated more significantly with Internet addiction than with either depression or anxiety symptoms, whereas the child reports, depression contributed more to Internet addiction than did ADHD symptoms. Conclusion:These results suggest we might need to pay more attention to diagnosing and treating Internet addiction, since different informants could be reporting the variables affecting internet addiction differently.