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최진현(Jinhyun Choi),박서현(Seo Hyun Park),강진오(Jin Oh Kang) 대한방사선종양학회 2010 Radiation Oncology Journal Vol.28 No.3
목 적: 본 연구는 방사선 종양학과의 학술적 네트워크의 구조적 특성과 네트워크의 형성에 영향을 미치는 요인을 밝히고자 하였다. 대상 및 방법: KoreaMed 데이터베이스에서 1986년부터 2010년 4월 30일까지 국내에서 발간된 논문 중 방사선종양학과가 저자와 기관으로 참여한 논문 1,512편을 발표 연도에 따라 구분하여 네트워크 중심성 및 key player 인덱스를 구하여 비교하였다. 네트워크 분석은 UCINET 6.0을 이용하였고 sociogram을 작성하기 위해 Netdraw 2.090을 사용하였으며, key player 분석은 KeyPlayer 1.44 프로그램을 사용하였다. 결 과: 방사선종양학 분야의 네트워크 집중도는 1986∼1990 기간 8.29%에서 2006∼2010 기간 1.84%로 현저하게 낮아졌으나 의학물리학회지를 제외하고 임상분야만을 보면 2001∼2005년 2.32%에서 2006∼2010년 3.80%로 최근 들어 다시 높아졌다. 기관별 중심성 분석에서는 서울대학교가 중심성 7.9%로 가장 높은 지역 중심성을 보이고 있었다. 외향 중심성과 내향 중심성도 모든 기간에 걸쳐 서울대학교가 가장 높았으며(6.50%, 8.54%), 사이 중심성(14.94%)과 위상 중심성(135.234%)도 같은 결과가 나타났다. Key player는 1986∼2010 기간에서 인하대학교로(0.491) 나타났으며 의학물리학회지를 제외하면 연세대학교가 0.584로 가장 높게 나타났다. 결 론: 방사선종양학 분야의 네트워크는 각 연구기관의 참여가 확산되고 네트워크 내에 특정 기관으로의 쏠림 현상이 완화되어 중심성이 낮아진 반면 그룹간 교류는 많지 않다. 방사선종양학 분야의 학술적 발전을 위해서는 연구 그룹간 교류를 개선시킬 수 있는 연구 체계의 제도적 보안이 필요하다. Purpose: To evaluate the structural characteristics of a scientific network of radiation oncology society. Materials and Methods: A total of 1,512 articles published from 1986 to April 2010 with the terms ‘radiation oncology’ or ‘therapeutic radiology’ were obtained in the KoreaMed database. The co-authors were analyzed according to their affiliation, and their relationship was used to build a matrix. With the matrix, centralization indices and the Key Player index were analyzed. We used UCINET 6.0 for the network analysis, Netdraw for determining a sociogram and Key Player 1.44 for the key player analysis. Results: The centralization of the radiation oncology field decreased from 8.29% for the period from 1986∼1990 to 1.84% from 2006∼2010. However, when the Korean Journal of Medical Physics was excluded, centralization increased from 2.32% for the period from 2001∼2005 to 3.80% from 2006∼2010. This suggested that the communication in the clinical research field of radiation oncology is decreasing. In a node centralization analysis, Seoul National University was found to be the highest at 7.9%. Seoul National University showed the highest indices in the Outdegree (6.50%) and Indegree (8.54%), in addition to Betweenness (14.94%) and Eigenvector (135.234%). The Key Player analysis indicated that Inha University had the highest index at 0.491, but when the Korean Journal of Medical Physics was excluded, Yonsei University had the highest Key Player index at 0.584. Conclusion: The degree centrality in the network of radiation oncology decreased in the most recent period as more institutions are participating in network. However, the Betweenness centrality is still increasing, suggesting that the communications among research groups (clique) in radiation oncology is warranted.
인공피부를 위한 키토산-PLGA-PEO 나노섬유/PLGA 마이크로섬유 융복합 지지체
임현주 ( Hyun Ju Lim ),김철주 ( Cheol Joo Kim ),오은정 ( Eun Jung Oh ),김태정 ( Tae Jung Kim ),정소연 ( So Yeon Jung ),최진현 ( Jin Hyun Choi ),이원주 ( Weon Ju Lee ),권오형 ( Oh Hyeong Kwon ),정호윤 ( Ho Yun Chung ) 한국조직공학과 재생의학회 2011 조직공학과 재생의학 Vol.8 No.2s
When the skin is seriously damaged through disease or trauma, artificial skin using synthetic or natural polymer is essential due to limitation of self-repair and donor-site morbidity. Generally, microfiber has demerit of cell maintenance limits after cell seeding and nanofiber has demerit of structural weakness. In this study, we prepared hybrid scaffolds composed of the nanofibers of chitosan-poly(lactic-co-glycolic acid) (PLGA)-poly ethylene oxide and microfibers of PLGA for artificial skin. The morphology and hydrophilicity of the scaffolds were characterized by scanning electron microscope (SEM) and contact angle machine. Dermal sheath cells, one of hair follicle stem cells were applied on the scaffolds and analyzed. Hybrid scaffolds possessed high hydrophilicity and exhibited good cell adhesion and viability at appropriate nano/microfiber ratio. Thus, this hybrid scaffold shows a potential as a material for artificial skin.
Ga Hyun Lee(이가현),Sung June Lee(이성준),Sang Won Jeong(정상원),Hyun-Chul Kim(김현철),Jin Hyun Choi(최진현),Se Geun Lee(이세근) 한국고분자학회 2015 폴리머 Vol.39 No.6
의료용으로 사용되고 있는 고분자는 체내에 적용했을 경우 초기의 염증반응이 종종 문제점으로 대두되며, 이는 면역세포의 활성산소의 배출과 관련되어 있다. 본 연구에서는 이러한 부작용을 해결하기 위해 항산화제를 필름표면에 코팅하여 활성산소 발생 저해에 의한 항염증 효과를 평가하고자 하였다. Macrophage에 의한 염증 효과를 평가한 결과, 항산화제가 코팅된 polylactic acid 필름에서 pro-inflammatory cytokine의 생성이 저해됨을 확인하였다. 또한 항산화제 코팅 시 코팅제로 사용되는 고분자의 종류 및 분자량에 따른 방출 거동을 관찰한 결과, 고분자의 종류 및 분자량에 따라 항산화제의 방출 제어가 가능하였다. 이는 항염증 반응에 효과적으로 대응할 수 있는 항산화제 코팅 polylactic acid 필름을 제조함으로써 다양하고 광범위한 체내용도 전개가 가능할 것으로 생각된다. Polylactic acid (PLA) films have been widely used in medical devices for surgical treatments. However, their use has been associated with complications, such as inflammation around the PLA film implant area. Several antioxidant agents have been incorporated on the surface of PLA films to suppress initial excessive inflammatory reactions through the quenching of reactive oxygen species (ROS) released from macrophages. The suppression of inflammation was evaluated by measuring the levels of various pro-inflammatory cytokines produced by the macrophages. In addition, by measuring quercetin release behavior, we determined the optimum type and molecular weight of the film coating polymer for the effective suppression of inflammation. These results suggest that the incorporation and controlled release of quercetin could be a promising method to reduce inflammation induced by PLA films.
KUSA-A1 골조세포 함유 키토산 지지체를 이용한 생체내 골재생
임현주(Hyun Ju Lim),오은정(Eun Jung Oh),최진현(Jin Hyun Choi),정호윤(Ho Yun Chung),김한도(Han Do Ghim) 한국고분자학회 2012 폴리머 Vol.36 No.4
KUSA-A1 골조세포로부터 골재생을 유도하기 위하여, 스폰지형(CSS) 및 부직포형(CSNW)의 키토산 지지체 를 적용하였다. CSNW의 표면적 및 공극 크기는 CSS에 비해 상대적으로 큰 값을 나타낸 반면, 공극 부피는 CSNW의 경우가 CSS에 비해 작은 값을 보였다. 세포고정 시험 결과는 CSNW의 경우가 더 적합한 결과를 나타내었으며, 이는 지지체의 넓은 표면적에 기인한 것으로 판단되었다. In vivo 실험을 위하여 세포를 각각의 지지체에 투여 후 일주일간 배양하였으며, BALB/C 무모생쥐의 피하조직에 이식하였다. 이식된 지지체는 각각 수술 후 1, 4, 6 및 8주에 채취되어 면역학적 염색을 실시하였다. CSS는 수술후 4주에서 6주 사이에 붕괴되기는 하였으나, 조직의 안정성은 CSNW에 비해 우수한 것으로 관찰되었다. 골조직의 생성은 CSNW와 CSS에 대해 각각 4주 및 8주에서 이루어짐을 확인하였다. For bone regeneration from KUSA-A1 oesteoblast cells (KUSA), chitosan (CS) scaffolds possessing different surface properties, sponge-type (CSS) and nonwoven-type (CSNW), were manufactured. Surface area and pore size of CSNW were larger than those of CSS. On the other hand, the pore volume of CSNW was smaller than that of CSS, Cell attachment evaluation showed CSNW was more adequate then CSS, and this was attributed to the large surface area. For in vivo investigation, KUSA were seeded into CS scaffolds in wells followed by a week of cell culture. Obtained CS scaffolds with KUSA were implanted on the subcutaneous tissue of BALB/C nude mice. After surgery, implanted scaffolds were harvested and assayed by immunological staining. Network stability of CSS was better than that of CSNW, even if CSS scaffolds were destroyed between 4 and 6 weeks. Calcification was observed after 4 and 8 weeks for CSNW and CSS, respectively.
쥐 회전근개 파열 모델의 건 부착부에서 카토제닌 주사의 효과
김동현 ( Dong Hyun Kim ),민승기 ( Seung Gi Min ),김훈민 ( Hun-min Kim ),최진현 ( Jin-hyun Choi ),이현주 ( Hyun Joo Lee ),박경현 ( Kyeong Hyeon Park ),윤종필 ( Jong Pil Yoon ) 대한스포츠의학회 2020 대한스포츠의학회지 Vol.38 No.4
Purpose: The purpose of this study was to investigate the effects of kartogenin (KGN) on the tendon-bone interface in a rat rotator cuff tear model. Methods: Twenty male rats were divided into two equal groups; group 1 (repair only) and group 2 (KGN single injection). A rat rotator cuff rupture model was prepared, and KGN (500 μM) was injected into the repair site. The specimens were collected after 8 weeks, and biomechanical and histological analyses were performed. We assessed the healing quality of the tendon-to-bone repair site using six aspects of tendon tissue. The histological findings were classified semiquantitatively into four grades (grade 0, the poorest appearance; grade 1, poorer; grade 2, better; and grade 3, marked regeneration). Results: Group 2 showed a higher mean ultimate load to failure than the control group (group 1: 25.78±31.38 N, group 2: 55.64±36.02 N; p=0.011). On histological analysis, group 2 exhibited a significantly greater total score (group 1: 7.20±2.14, group 2: 9.50±1.84; p=0.019), collagen fiber continuity (group 1: 1.20±0.42, group 2: 1.70±0.48; p=0.024), and collagen fiber density (group 1: 1.50±0.52, group 2: 2.20±0.63; p=0.080). Metachromasia were more intense in group 2 than in the control group. Conclusion: A single injection of KGN reinforces biomechanical strength and the formation of collagen and fibrocartilage at the tendon-to-bone interface in a rat rotator cuff tear model.