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최진미,김미리혜 덕성여자대학교 학생상담센터 2009 學生生活硏究 Vol.25 No.-
2009년도 덕성여자대학교 신입생 및 그 가정의 제반특성을 파악하기 위하여 인적 사항, 가정환경, 입학 만족도, 대학생활, 가치관, 자신에 대한 지각, 강의주제 등에 관한 설문조사를 실시하였다. 총 신입생 1445 명 중 응답자 1363명의 자료를 분석하여 각 문항 별로 신입생 전체는 물론 각 학부의 응답 빈도 및 비율을 제시하였다. 되풀이 확인된 결과로는 우선, 대다수의 학생들이 수도권지역의 고등학교를 졸업하였으며 중산층 이상의 가정 출신이라는 점이다. 대부분 부모 가 모두 생존해 계시고 고졸이상의 학력을 가지고 있다. 두 번째, 학생들은 취업에 큰 관심을 가지고 있으며 장래 취업을 준비하기 위해 대학에 진학했다고 답한 경우가 많았다. 이외에도 대학별 특징 등 중요한 결과들을 논의에서 요약하였고, 그 결과들이 시사하는 바를 제언하였다. Examined the characteristics of the students who entered Duksung Women's University in 2009. The total number of 1363(out of 1445) undergraduates completed an autobiographical questionnaire which inquires about demographic variables, family environment, satisfaction with the university, expectancies of a campus life, value system, self-concept, and lecture subject. Results show that a majority of the students were graduated from high schools located in Seoul. Both of their parents are alive, in the middle or higher socioeconomic groups and of high educational accomplishment(at the lowest, high school graduates). One of the replicated findings is that students are highly interested in career development. A great proportion of career preparation. The result also indicate that many students have chosen our university solely based on their grades. And many students report that they are satisfied with their choice, which is very encouraging. Other result such as the characteristics unique to each college are also summarized and several suggestions are presented in the discussion section.
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최진미,김남재 한국임상심리학회 2009 Korean Journal of Clinical Psychology Vol.28 No.3
In this study, we empirically investigated early maladaptive schemas in subjects with eating problems to help identify the underlying origin of such problems. First, we identified groups of subjects having anorexic tendency(AN), bulimic tendency(BN), restricting bulimic tendency(RBN) and normal group from 450 female college students. The results, derived using the Young Schema Questionnaire(YSQ), indicated that the eating disorder groups had higher scores than the normal group did and, among the eating disorder groups, the RBN group had higher scores than did the AN or BN group on YSQ scores. In detail, among the 3 eating disorder groups, there were no significant differences with regard to mistrust/abuse scores. On the other hand, the AN group showed more maladapted scores than the BN group did with regard to abandonment, subjugation, while the RBN group had the most maladapted scores of all in these areas(i.e., BN<AN<RBN). In fact there was no significant difference between the BN group and the normal group with regard to subjugation scores. This suggests such schemas are more closely associated with the AN tendency than with the BN tendency. Though scores pertaining to enmeshment, emotional inhibition and insufficient self-control were more maladapted in BN than AN and most maladapted in RBN(AN<BN<RBN), these differnces were not statistically significant. Nevertheless, this suggests the possibility that these 3 schemas may be more closely associated with the BN tendency than with the AN tendency. We concluded by not only discussing the possible causality between eating disorders and maladaptive schemas, coping style on maladaptive schemas, and limitations of this study but presenting suggestions for future studies.
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최진미,김미리혜 덕성여자대학교 학생상담센터 2010 學生生活硏究 Vol.26 No.-
대학생 시기는 체형과 외모에 관심이 높고 생활패턴이 변화하는 시기이며 식생활에 전환점을 맞는 시기이다. 특히 나 사회문화에 민감한 여자대학생들은 평균 수준임에도 불구하고 체중감량의 필요성을 느끼고 실제로 감량에 시도 한다. 왜곡된 신체상으로 건강하지 않은 식이행동을 하며 불안이나 우울로 대표되는 부정적인 정서를 경험한다. 분 연구에서는 423명의 덕성여자 대학생을 대상으로 식이행동과 우울 및 불안에 대한 조사를 했다. 성실히 답한 422 명의 학생 중 156명은 전문가의 도움이 필요한 ‘건강하지 않은 식이행동’을 하는 것으로 나타났다. 전체 응답자의 53.1%인 224명이 우울한 상태이며 이 중 91명은 전문가의 상담이나 치료가 필요한 상태로 보고하였다. 65명(15.4%)의 학생이 불안상태로 나타났다.
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Menin Enhances Androgen Receptor-Independent Proliferation and Migration of Prostate Cancer Cells
Taewan Kim,정관영,김은지,윤광현,최진미,박재현,김재환,김형식,윤홍덕,Eun-Jung Cho 한국분자세포생물학회 2022 Molecules and cells Vol.45 No.4
The androgen receptor (AR) is an important therapeutic target for treating prostate cancer (PCa). Moreover, there is an increasing need for understanding the AR-independent progression of tumor cells such as neuroendocrine prostate cancer (NEPC). Menin, which is encoded by multiple endocrine neoplasia type 1 (MEN1), serves as a direct link between AR and the mixed-lineage leukemia (MLL) complex in PCa development by activating AR target genes through histone H3 lysine 4 methylation. Although menin is a critical component of AR signaling, its tumorigenic role in AR-independent PCa cells remains unknown. Here, we compared the role of menin in AR-positive and AR-negative PCa cells via RNAi-mediated or pharmacological inhibition of menin. We demonstrated that menin was involved in tumor cell growth and metastasis in PCa cells with low or deficient levels of AR. The inhibition of menin significantly diminished the growth of PCa cells and induced apoptosis, regardless of the presence of AR. Additionally, transcriptome analysis showed that the expression of many metastasis-associated genes was perturbed by menin inhibition in AR-negative DU145 cells. Furthermore, wound-healing assay results showed that menin promoted cell migration in AR-independent cellular contexts. Overall, these findings suggest a critical function of menin in tumorigenesis and provide a rationale for drug development against menin toward targeting high-risk metastatic PCa, especially those independent of AR.
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Ctbp2-mediated β-catenin regulation is required for exit from pluripotency
김태완,곽소정,신지훈,강병희,이상은,서민영,김재환,황인영,이종혁,최진미,조은정,윤홍덕 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
The canonical Wnt pathway is critical for embryonic stem cell (ESC) pluripotency and aberrant control of β-catenin leads to failure of exit from pluripotency and lineage commitments. Hence, maintaining the appropriate level of β-catenin is important for the decision to commit to the appropriate lineage. However, how β-catenin links to core transcription factors in ESCs remains elusive. C-terminal-binding protein (CtBP) in Drosophila is essential for Wnt-mediated target gene expression. In addition, Ctbp acts as an antagonist of β-catenin/TCF activation in mammals. Recently, Ctbp2, a core Oct4-binding protein in ESCs, has been reported to play a key role in ESC pluripotency. However, the significance of the connection between Ctbp2 and β-catenin with regard to ESC pluripotency remains elusive. Here, we demonstrate that C-terminal-binding protein 2 (Ctbp2) associates with major components of the β-catenin destruction complex and limits the accessibility of β-catenin to core transcription factors in undifferentiated ESCs. Ctbp2 knockdown leads to stabilization of β-catenin, which then interacts with core pluripotencymaintaining factors that are occupied by Ctbp2, leading to incomplete exit from pluripotency. These findings suggest a suppressive function for Ctbp2 in reducing the protein level of β-catenin, along with priming its position on core pluripotency genes to hinder β-catenin deposition, which is central to commitment to the appropriate lineage.
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