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RISS 인기검색어
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- 저자 : 최준한(Joon Han Choi) (검색결과 4 건)
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CCl<sub>4</sub> 로 독성유발시킨 초대배양 간세포를 이용하여 간세포 보호효과를 나타내는 생약류의 검색
이준우(June Woo Lee),최준한(Joon Han Choi),강상모(Sang Mo Kang) 한국생약학회 1993 생약학회지 Vol.23 No.4
We studied to screen medicinal plants having hepatoprotective activity with the primary cultured rat hepatocytes intoxicated with carbon tetrachloride cyto toxicity. The lowest concentration and treatment time of carbon tetrachloride giving the greatest intoxication to the primary cultured hepatocytes were observed in l0mM and 60 minutes, respectively. GTP and GOT activity of culture broth of the primary cultured rat hepatocytes intoxicated by CCl₄ cytotoxicity at this condition were increased 135.9% and 178.3% compared with that of the primaries cultured hepatocytes not treated with CCl₄, respectively. This increased GPT activity was inhibited by glycyrrizin, which was known to have hepatoprotective activity, and the inhibition activity was dependent on the concentration of glycyrrhizin. Forty species among the extracts obtained from 117 species of medicinal plants were shown to have the hepatoprotective activity. Among these 40 species, Pruuus persica, Scutellaria baicalensis, Astragalus membranaceus, Tribulus terrestris, Caragana chamlagu, Acanthopanax sessiliflorum and Achyranthes japonica were indicated a lower GPT activity than that of Glycyrrhiza uralensis containing glycyrrhizin and GPT activity of these were indicated 75.5%, 70.0%, 59.0%, 77.5%, 60.0%, 75.0% and 79.0%, respectively.
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한태근,최준 인제대학교 1993 仁濟醫學 Vol.14 No.3
현대사회가 발달하면서 거주의 형태나 생활의 양식이 변하고 있다. 특히 도시의 경우에는 아파트의 밀집, 핵가족화, 여성의 사회참여 등으로 소아의 보호여건이 변하고 있으며 그 외상의 원인 및 상황도 다양한 유형으로 나타나고 있다. 저자는 밀집저주지역에서 소아외상환아를 조사 분석하여 소아외상의 이해와 그에 따른 예방 대책을 세우고자 1989년 9월 1일부터 1970년 8월 31일까지 인제대학교 상계백병원 응급실로 내원한 1452명을 대상으로 장소별, 시간별, 원인별, 보호자의 유무, 외상의 원인된 물체 등으로 분석하여 다음과 같은 결과를 얻었다. 성별비로는 남자가 전체의 67.2%로 더 많았으며 연령별로는 걸음마기(2∼4세)가 47.0%로 가장 많았으며 외상이 가장 많이 발생한 시간은 18시부터 21시 사이였다. 외상의 발생 장소는 54.2%가 집안이었으며 78.7%에서 사고 당시 보호자가 주위에 있었고 더구나 외상에 원인 중 21.5%가 부모의 과실이나 체벌 등이었다. 외상의 원인이된 물체는 특이한 것 없이 행동반경 내의 모든 것이 그 대상이었다. 이상의 결과로 미루어 소아 보호환경의 개선, 안전교육 강화, 놀이기구와 놀이터시설의 안정성 확보등의 대책도 중요하지만 아울러 부모들의 어린이의 안전에 대한 관심이 소아외상 발생을 줄이는 가장 중요한 길이라 하겠다. With the development of contemporary society, forms of residence and ways of life are changing. Particularly in cities, the conditions of child protection are undergoing changes, and the causes and circumstances of pediatric trauma are found in diverse patterns, owing to the trend toward concentrated apartment houses, nuclear familiesm women's social participation, etc. In order to understand and take preventive measures against pediatric trauma through surveying and analyzing externally wounded children in concentrated residential areas. I examined 1452 children who came to the emergency room of Sanggye Paik hospital, Inje University, by place, time, cause, causative object, of their external wounds, and their protector, from Sept. 1, 1989 to Aug. 31, 1990, securing the following result : In sexual distribution ratio, males are 67.2% of the whole. a ratio exceeding that of females. By age, toddler(2-4 years of age) are 47.0%, a percentage higher than that of any other age bracket. By time, most external wounds took place at 18:00-21:00 o'clock. As to place, 54.2% was at home. In cases of 78.9% some protector was nearby at the time of accident. Moreover, 21.5% of the causes of wounds was their parents carelessness or physical punishment by the same. Objects causative of trauma were anything with no distinction in an action radius. In view of the foregoing result, we may come to the conclusion that necessary steps against pediatric trauma are the improvement of protective surroundings for children, the intensification of safety education, the security of safe playthings and playgrounds, etc., but the most important of all is parents' interest in the safety of their children.
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