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RISS 인기검색어
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- 저자 : 최종호(Jung Ho Choe) (검색결과 2 건)
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만성 (慢性) 무증상 (無症狀) B형 간염 (肝炎) 표면항원 (表面抗原) 보유자에 (保有者) 있어서 조직학적 (組織學的) 연구
조민구(Min Koo Cho),원남희(Nam Hee Won),서승봉(Seung Bong Suh),최종호(Jung Ho Choe),조경준(Kyeong Joon Cho),박병익(Byung Ick Park) 대한소화기학회 1985 대한소화기학회지 Vol.17 No.1
N/A We performed liver needle biopsies on 34 chronic asymptomatic hepatitis B surface antigen (HBsAg) carriers with normal liver function tests. Among them, 12 were found to carry HBeAg and 14 carried anti-HBe. The results were as follows: 1) Of the 34 chronic asymptomatic HBsAg carriers, normal histologies were found in 9, nonspecific reactive changes in 15, chronic persistent hepatitis (CPH) in 9 and chronic active hepatitis (CAH) in l. 2) Of the 12 HBeAg positive carriers, normal histologies were found in 2, nonspecific reactive changes in 6 and CPH in 4 and of the anti-HBe positive carriers, normal histologies were found in 4, nonspecific reactive changes in 6, CPH in 3 and CAH in 1. There was no significant difference between two groups. According to these results, a substantial proportion of chronic asymptomatic HBsAg carriers had histological abnormalities and the status of HBeAg and anti-Hbe did not correlate with liver histology. Qur opinion is liver biopsy is still remains the most useful approach in the evaluation of asymptomatic HBsAg carriers and further long-term clinical studies are needed to understand the prognosis of chronic asymptomatic carrier state.
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각종 간질환자에서 혈청 Beta2-microglobulin 치의 임상적 의의
이권준,조민구,최종호,김소연,장석원,조태봉 대한핵의학회 1985 핵의학 분자영상 Vol.19 No.2
To evaluate the significance of serum beta₂-microglobulin in patients with various liver diseases, serurn Beta₂ m levels were measured in 44 cases of normal controls, 32 cases of asymptomatie HBsAg carriers and 134 patients with various liver diseases, by radioimmunoassay using Phadebas Beta2~micro test kits. The following results were obtained: I) The mean level of serum β₂ m was 1 39+-0.25㎎/ℓ(Mean+-S.D.) in normal controls (1.39+-0.23㎎/ℓ in 24males, 1.38+-0,27㎎/ℓin 20 fernales). 2) The seram levels of B2m in patients with various Iiver diseaaes and asymptomatic HBsAg carriers were as follows; 1.400.27㎎/ℓ in asymptomatic HBsAg carriers, 2.42+-0.377 mg/l in 45 patients with acute viral hepaitis, 2.10+-0.26 mg/l in 46 patients with chronic persistent hepatitis, 2.60+-0.34㎎/ℓin 23 patients with chronic active hepatitis, and 2.60+-0.49 ㎎/ℓin 20 patients with liver cirrhosis. Serum β₂ m levels of each disease group were significantly higher than that of normal controls(p$lt;0.001). 3) There was significant correlation between the levels of serum β₂ m and the degrees of lymphocytic infiltration in patients with chronic active hepatitis(p$lt;0.001). 4) Significant correlations were observed between the levels of serum betA₂,-microglobuin and serum alanine aminotransferase(r=0.68, p$lt;0.05) and bilirubin(r=0.63, p$lt;0.05) in 15 patients with acute viral hepatitis. In conclusion, the serum beta₂,-microglobulin levels were increased in patients with various liver diseases, and it may serve as a new index of liver disease activity.
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