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치매 환자에서 뇌 자기공명영상의 특징과 비정형 항정신병 약제 사용여부의 상관 관계
최종택,김지원,노양호,류석환,우성일,한상우,황재욱,Choi, Jongtaek,Kim, Jiwon,Roh, Yangho,Rhu, Sukhwan,Woo, Sungil,Hahn, Sangwoo,Hwang, Jaeuk 대한생물정신의학회 2013 생물정신의학 Vol.20 No.3
Objectives We aimed to identify the neuroimaging marker for prediction of the use of atypical antipsychotics (AAP) in dementia patients. Methods From April 2010 to March 2013, 31 patients who were diagnosed as dementia at the psychiatric department of Soonchunhyang University Hospital, completed the brain magnetic resonance imaging scan and cognitive test for dementia. Ten patients were treated with AAP for the improvement of behavioral and psychological symptoms of dementia (BPSD) and the other 21patients were not. Using T1 weighted and Fluid Attenuated Inversion Recovery (FLAIR) images of brain, areas of white matter (WM), gray matter (GM), cerebrospinal fluid (CSF) and white matter hyperintensities (WMH) have been segmented and measured. Multivariate logistic regression models were applied for assessment of association between AAP use and the GM/WM ratio, the WMH/whole brain (GM + WM + CSF) ratio. Results There was a significant association between AAP use and the GM/WM ratio (odds ratio, OR = 1.18, 95% confidence interval, CI 1.01-1.38, p = 0.037), while there was no association between AAP use and the WMH/whole brain ratio (OR = 0.82, 95% CI 0.27-2.48, p = 0.73). Conclusions The GM/WM ratio could be a biological marker for the prediction of AAP use and BPSD in patients with dementia. It was more likely to increase as dementia progress since atrophy of WM was more prominent than that of GM over aging.
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최종택(Choi Jongtaik) 고구려발해학회 2014 고구려발해연구 Vol.50 No.-
1979년 중원고구려비 발견이후 구조적으로 고구려 고분과 유사한 고분이 남한지역에서 간헐적으로 조사되었다. 1988년 몽촌토성에서 고구려 유적과 유물이 조사되면서 남한지역 고구려 유적에 대한 조사가 활기를 띠기 시작했다. 1994년에는 한강북안의 아차산 일원에서 20여개소의 고구려 보루가 확인되었고, 1997년부터는 발굴조사가 시작되었다. 1999년에는 임진·한탄강유역과 양주분지에서 다수의 고구려 관방유적이 확인되었으며, 이후 금강유역에서도 고구려 산성이 발굴되었다. 최근 2000년대 이후 고구려 토기가 부장된 고분의 조사사례가 증가하고 있으며, 일부 고구려 고분군의 주변에서는 취락유적이 조사되고 있다. 이 글에서는 남한지역 고구려유적의 조사현황을 살펴보고, 고구려 남진의 물적 증거인 고분과 관방유적에 대한 그간의 연구 성과를 검토한 후 향후의 연구를 전망해보았다. 남한지역에서 고구려유적이 조사되고 연구된 것은 비록 짧은 기간이었지만 상당한 연구 성과를 거둔 것으로 생각된다. 현재 남한지역에서 조사된 가장 이른 시기의 고구려 유물은 파주 주월리유적에서 출토된 구형호 등으로 4세기 후엽 또는 4세기말로 편년된다. 그 다음으로는 세장방형묘실의 횡혈식석실분으로 5세기 중엽 경에 해당된다. 5세기 후엽에는 장방형 묘실의 횡혈식석실분이 축조되었으며, 아울러 몽촌토성과 대모산성, 남성골산성, 월평동유적, 은대리성, 당포성 등도 이 시기에 해당된다. 이후 6세기 전반에는 한강 북안의 아차산일원에 고구려 보루가 축조되어 551년까지 존속한 것으로 밝혀지고 있다. 양주분지와 임진·한탄강유역의 보루들도 대체로 5세기 중반 이후에 축조된 것으로 이해되나 폐기시점에 대해서는 추가의 연구가 필요하다. 지금까지의 연구 성과를 통해 볼 때 고구려는 4세기 후반 이후 북한강 상류와 남한강상류를 통해 충주지역으로 진출하였는데, 연천 강내리고분군과 춘천 방동리 2호분 및 충주 두정리고분군과 같은 세장방형 고분은 고구려의 충주지역 진출 및 영역화와 관련된 것으로 추정된다. 한편 475년 한성공함이후 고구려군은 몽촌토성에 주둔하고 진천과 청원, 대전으로 진출하였으며, 점령지에 대한 영역화를 시도했던 것으로 이해되는데, 5세기 후엽 이후의 장방형고분들은 이러한 영역화 과정에서 축조된 것으로 생각된다. 또한 이 고분들 인근에서 고구려의 취락유적이 속속 조사되고 있으며, 이를 통해 볼 때 고구려가 남한지역에 대한 영역화를 적극적으로 시도하였으며, 일정기간 지속되었던 것으로 이해된다. It was only after the excavation of Mongchon Earthen Wall in 1988 that the artifacts and sites of Koguryo were appreciated in South Korea for the rfsit time. Thereafter, A series site surveys identified a number of fortifications at M. tAcha, and the excavation of a fortress No. 4 since 1997 has accelerated the study of Koguryo archaeology. Since then, a number of fortresses and pottery data have been additionally identified and reported in Han River Valley, Yangju Basin, Imjin River and Geum River Valleys. These new archaeological data provided comprehensive information on the archaeological characteristics of Koguryo sites and allowed the chronology of Koguryo pottery in South Korea. They also greatly helped to understand a series of historical events which had occurred in South Korea area from the 4th to 7th century in terms of archaeological perspective. Meanwhile, In 1981 a Koguryo-type stone chamber tomb was reported at Bangdong-ri in Chuncheon, for the first time in South Korea. Since then, a number of tombs, which are similar to the Bangdong-ri tomb in structural features, were found in South Korea. In these tombs, however, few artefacts were found which are typically found in Koguryo-type tombs. Subsequently, little progress has been made in studying this type of tombs in South Korea. It is since the second half of the 2000s that the cases, in which Koguryo pottery was found in that type of tombs, increased in number. As a result, the existence of Koguryo tombs in South Korea was confirmed. The tombs, which have a long-rectangular shaped chamber and a coffin placed directly on the fire-hardened chamber-floor without a platform for coffin, are dated to the mid 5fth century. The tombs with a rectangular-shaped chamber are dated to the late 5th century. At the same time Mongchon Earthen Wall, Namseonggol Fortress, Eundaeri Fortress and Dangposeong fortress were constructed in the late 5th century. In the early 6th century, Mt. Acha Fortresses were constructed and lasted to 551. Most of fortresses in Yangju Basin and Imjin River Valley were constructed after the middle 5th century. But it is not clear that at the time of disused. This chronology, together with historical circumstances, suggests that the tombs with a long-rectangular shaped chamber were constructed in relation to the expansion of Koguryo to central Korea in the mid 5th century, and that the tombs with a rectangular-shaped chamber were made after Hanseong had fallen in 475. Settlement or fortress sites found around the areas, where tombs are located, indicate the possibility that Koguryo tried to govern the lower area of the Han River and the upper areas of the Bukhan and Namhan Rivers, as part o tfheir territory.
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아차산성과 삼국의 상호관계 : 아차산성에 대한 고고학적 조사 성과와 과제
최종택 ( Jong Taik Choi ) 고려대학교 역사연구소 2014 사총 Vol.81 No.-
Achasanseong Fortress, located at Gwangjin-gu in Seoul, is thought of as Adanseong of Baekje. Based on Samguksagi, Achasanseong Fortress appears to have been built in 286. In 396 this fortress was attacked by Koguryo. Written evidence says that King Gaero of Baekje was killed at Adanseong by the Koguryo army in 475 when Hanseong was attacked by Koguryo. Archaeological surveys of Achasanseong Fortress have been conducted from 1994 until 1999 over several times. The surveys reveal that Achasanseong Fortress is a mountain fortress encircling a valley. The fortress is 1038.58 meters around, and has a plan shape of an irregular hexagon. Its external and internal walls were both built with trimmed stones. The original height of the walls appears to have been 7-8 meters. Another wall was constructed to reinforce the lower part of the external wall. This construction method is usually observed in Silla fortresses dated later than the late fifth century. The gates were made on the southern and eastern parts of the fortress, with the eastern gate being a suspensible gate. Inside the fortress, a well, reservoir facilities, many building foundations, and so on were discovered. The finds suggest that the walls were built in the early seventh century and used until the mid ninth century. Roofing tiles with letters written on them imply the possibility that Achasanseong Fortress was used as Bukhansanseong Fortress of Silla after the early seventh century. Archaeological surveys of Achasanseong Fortress have yielded important information about some aspects of Achasanseong Fortress. However, previous surveys on the fortress were conducted to a limited extent in the forms of a surface survey or a trial digging, only providing us with partial data of the fortress. In particular, there is little evidence on when the fortress was first built, how it was used as Adanseong of Baekje, and what the fortress was like when Hanseong was attacked and after then. These remain to be revealed through future surveys.
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