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대장암 예후인자로서 18번 염색체 홑염색체(Monosomy)의 의의
최유신(Yoo Shin Choi),임현묵(Hyun Muck Lim),김범규(Beom Gyu Kim),이태진(Tae Jin Lee) 대한외과학회 2007 Annals of Surgical Treatment and Research(ASRT) Vol.73 No.3
Purpose: Chromosomal instability of chromosome 18 and inhibition of the transforming growth factor beta (TGF-β) signaling pathway, which is mediated through Smad4, play important roles in the tumorigenesis of colon cancer. This study evaluated the value of the expression of chromosome 18 monosomy in colon cancer as a prognostic factor and its correlations with the expressions of Smad4 and TGF-β receptor Ⅱ proteins. Methods: We analyzed the rate of the expression of chromosome 18 monosomy in 66 colon cancers with using chromogenic in situ hybridization (CISH) and we evaluated its value as a prognostic factor by determining its correlation with the pathologic factors and immunohistochemical expressions of Smad4 and TGF-β receptor Ⅱ proteins. Results: Of the 66 colon cancers, monosomy of chromosome 18, as determined by CISH, was observed in 18 cases (27.3%), and the decreased expression of Smad4 and TGF-β receptor Ⅱ proteins was observed in 30 cases (45.5%) and 25 cases (37.9%), respectively. The monosomy of chromosome 18 and the decreased expression of Smad4 proteins showed statistically significant correlations with the histologic differentiation, the presence of tumor emboli, the nodal status and the stage. The decreased expression of TGF-β receptor Ⅱ proteins had statistically significant correlations with the histologic differentiation, the T-stage, the nodal status and the stage. The monosomy of chromosome 18 showed a statistically significant correlation with the decreased expression of Smad4 and TGF-β receptor Ⅱ proteins. Conclusion: These results suggested that chromosome 18 monosomy may have prognostic value for colon cancer.
개복하 부신 절제술 경험이 없는 단일 술자에서 시행된 복강경하 부신 절제술의 학습곡선 및 초기 임상 경험 분석
이동헌,최유신,박성준,Dong Heon Lee,Yoo Shin Choi,Sung Jun Park 대한갑상선-내분비외과학회 2013 The Koreran journal of Endocrine Surgery Vol.13 No.4
Purpose: Adrenalectomy is a very rare operation and its associated learning curve has not yet been studied. The objective of this study was to determine whether the operation time decreases with experience and to evaluate the safety and feasibility of laparoscopic adrenalectomy performed by a surgeon who is new to laparoscopic and open-surgical adrenalectomy. Methods: This study is a retrospective analysis of laparoscopic adrenalectomies performed between April 2007 and September 2012. All surgeries were performed by a single young surgeon who had no experience in performance of open or laparoscopic adrenalectomy. All surgeries were performed using the transperitoneal approach. Results: In total, 42 cases were included. The average tumor size was 4.7 cm. The mean operating time was 125 min. Mean duration of hospital stay was 8.7 days. None of the cases showed conversion to open surgery or perioperative mortality. The operator achieved mastery after performance of left laparoscopic adrenalectomy in 12 cases and right laparoscopic adrenalectomy in 11 cases. Conclusions: A new surgeon can perform laparoscopic transperitoneal adrenalectomy successfully, independently, and safely after having performed the surgery in 12 cases.
갑상샘 소포샘종과 소포암에서 세포주기 관련단백과 세포자멸사 관련단백 발현의 의의
황준영(Jun Young Hwang),최유신(Yoo Shin Choi),박성준(Sung Jun Park) 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.76 No.1
Purpose: To explore the role of cell cycle regulators and apoptosis regulators in carcinogenesis of thyroid, the expression of cell cycle related proteins (cyclin D1, Ki-67) and apoptosis related proteins (survivin, caspase 3, bcl-2, p53) were investigated in follicular adenoma and follicular carcinoma of thyroid. Methods: The following formalin-fixed paraffin embedded surgical specimens were immunohistochemically stained by avidin-biotin complex method for cyclin D1, Ki-67, survivin, caspase 3, bcl-2, p53; 15 cases of follicular adenoma (FA), 31 cases of minimally invasive follicular carcinoma (MIFC) and 12 cases of widely invasive follicular carcinoma (WIFC). Results: The overexpression of six gene products in follicular neoplasms of thyroid was noted in varying frequency. Among them, increased Ki-67, caspase 3 index and overexpression of bcl-2 were noted in statistically significant, widely invasive follicular carcinoma than that of follicular adenoma and minimally invasive follicular carcinoma. Conclusion: These results suggest that the overexpression of Ki-67, caspase 3, bcl-2 appear to play an important role during follicular carcinogenesis of thyroid. In addition, the overexpression of these proteins is related to the differentiation of MIFC and WIFC. However, further molecular genetic studies are required to determine the interrelationships between the expression of cell cycle related proteins and apoptosis related proteins.
서승은(Seung Eun Suh),최유신(Yoo Shin Choi),이민구(Min Ku Lee),김창남(Chang Nam Kim),조병선(Byung Sun Cho),강윤중(Yun Jung Kang),박주승(Joo Seung Park) 대한외과학회 2007 Annals of Surgical Treatment and Research(ASRT) Vol.73 No.1
Gastric schwannoma is a very rare gastrointestinal mesenchymal tumor. Schwannoma in the gastrointestinal tract is usually not symptomatic, and preoperative abdominal CT or endoscopic evaluation cannot distinguish it from gastrointestinal stromal tumor. Surgical resection of this tumor is adequate to achieve a good prognosis. We performed laparoscopic gastric wedge resection in two patients who had the preoperative diagnosis of gastric gastrointestinal stromal tumor. In both cases, the postoperative immunohistochemistry staining was positive for S-100 protein and it was negative for CD34, which is consistent with gastric schwannoma. We report here on two cases of gastric schwannoma along with a review of the literatures.
강은혜 ( Eunhye Kang ),최유신 ( Yoo-shin Choi ),오형철 ( Hyoung-chul Oh ),도재혁 ( Jae Hyuk Do ),홍순억 ( Soon-uk Hong ),이승은 ( Seung Eun Lee ) 대한췌장담도학회 2022 대한췌담도학회지 Vol.27 No.1
췌장 선방세포암은 췌장암 중 1% 미만을 차지하는 매우 드문 암으로, 수술 전 영상 검사상 췌장관세포암, 췌장 고형성가유두상 종양, 신경내분비 종양 등과 감별이 어려운 경우가 많다. 현재까지 명확하게 정립된 치료법은 없으며, 조기 진단 및 종양의 완전 절제만이 생존율 향상을 가져온다고 보고되고 있다. 그러나 췌장 관세포암에 비하여 종양 절제 후 비교적 좋은 예후를 보여준다. 본 증례와 같이 비교적 젊은 남자 환자가 낭성 부분을 포함한 크기가 큰 고형성 췌장 종양을 주소로 내원하였을 경우 췌장 선방세포암을 염두에 두고 적극적인 수술 치료를 고려해야 할 것이다. Pancreatic acinar cell carcinoma (ACC) is a rare neoplasm accounting less than 1% of malignant pancreatic tumors. A 47-year-old male patient visited the emergency room with epigastric pain. Computed tomography or magnetic resonance imaging revealed a 4.7-cm heterogeneously enhanced solid and cystic mass with internal necrosis located in the head of the pancreas. Radiological diagnosis was borderline malignancy such as neuroendocrine tumor or solid pseudopapillary neoplasm. Two months later, the necrotic mass in the pancreas head had grown up to 11 cm, compressing the duodenum, superior mesenteric vein, and proximal transverse colon. Pylorus preserving pancreatoduodenectomy with segmental resection of transverse colon was performed. Histopathological examination revealed that the tumor was pancreatic ACC. The patient recovered without any complication and was doing well without recurrence for 12 months after surgery. Korean J Pancreas Biliary Tract 2022;27(1):54-59