타플루프로스트 점안 후 발생한 단순포진각막염 1예

박호균,최상경,Ho Gyun Park,Sangkyung Choi 대한안과학회 2013 대한안과학회지 Vol.54 No.12

Purpose: To report a single case of herpes simplex keratitis after application of 0.015% tafluprost eye drops. <br />Case summary: A 68-year-old male presented with left eye discomfort, epiphora, decreased visual acuity and hyperemia. The patient was diagnosed with glaucoma 6 weeks prior and started on 0.015% tafluprost eye drops in left eye and 0.15% brimonidine in both eyes. On slit lamp examination dendritic epithelial defect was observed and the patient was diagnosed with herpes simplex keratitis. The 0.015% tafluprost treatment was discontinued and 0.15% brimonidine was applied in both eyes twice a day. The herpetic keratitis in his left eye resolved completely in 2 weeks with acyclovir ointment and oral antiviral agent. No further recurrence was observed in the following 3 months.<br /> J Korean Ophthalmol Soc 2013;54(12):1950-1953

백내장 수술 중 발생하는 홍채이완증후군의 유병률 및 위험인자

박호균,최상경,Ho Gyun Park,MD,Sangkyung Choi,MD 대한안과학회 2014 대한안과학회지 Vol.55 No.1

Purpose: To determine the incidence and risk factors of intraoperative floppy iris syndrome (IFIS) in patients undergoing cataract surgery. Methods: The present study included 981 eyes of 655 patients who underwent cataract surgery and development and grade of IFIS were recorded. Correlation analysis was performed to determine the relationship between the IFIS and risk factors such as α1-adrenergic antagonist (tamsulosin, terazosin, alfuzosin), benzodiazepine, 5-α-reductase inhibitor, age, gender, hypertension, diabetes and glaucoma. Results: IFIS developed in 178 eyes (18.1%) out of 981 eyes. There was a correlation between the development of the IFIS and α1-adrenergic antagonist and benzodiazepine and male gender; however, there was no correlation with 5-α -reductase inhibitor, age, gender, hypertension, diabetes and glaucoma. IFIS grade tended to be higher as the cumulative dosage of the α1-adrenergic antagonist increased. Odds ratio of the patients using tamsulosin was the highest among the other risk factors, which was 3.8 times higher than the patients using terazosin, 9.0 times higher than the patients using alfuzosin and 11.1 times higher than the patients using benzodiazepine. Among patients who underwent cataract surgery on both eyes and who were confirmed with IFIS in 1 or both eyes, no significant grade differences between the 2 eyes were noted. Conclusions: Alpha 1-adrenergic antagonist and benzodiazepine were risk factors for the development of the IFIS, and as the cumulative dosage of the α1-adrenergic antagonist increased, the probability of developing a higher grade of IFIS increased. Therefore, predicting and preparing for potential IFIS in patients who have the above-mentioned risk factors are necessary before planning cataract surgery. Additionally, the IFIS aspect of the first eye could be utilized as a predictive value for developing IFIS profile of the fellow eye. J Korean Ophthalmol Soc 2014;55(1):73-78

고주파 전기수술기를 이용한 결막이완증 수술의 효과

서재신,최상경,Jae Shin Suh,MD,Sangkyung Choi,MD,PhD 대한안과학회 2012 대한안과학회지 Vol.53 No.11

Purpose: To evaluate the effects of conjunctivochalasis surgery using a high-frequency radio-wave electrosurgical unit. Methods: Twenty-seven eyes of 14 patients with conjuctivochalasis who received surgeries with shrinkage of the inferior bulbar conjunctiva using a high-frequency radio-wave electrosurgical unit (Ellman surgitron?) were evaluated. Conjuctivochalasis grade, the ocular symptoms, Ocular Surface Disease Index (OSDI), tear film break-up time (BUT), Schirmer test, and corneal staining with fluorescein were measured preoperatively, at 3 months postoperatively, and analyzed prospectively. Results: Three months after the surgery, all patients’ conjunctivochalasis became grade 0, and the ocular symptoms, OSDI score, BUT, and corneal staining with fluorerscein were also improved. Additionally, there were no specific complications during the follow-up period. Conclusions: Conjunctivochalasis surgery using a high-frequency radio-wave electrosurgical unit produced an effective improvement in conjuctivochalasis grade and symptoms and appeared to be a simple and safe procedure.

서로 다른 프로스타글란딘 제제 점안 후 발생한 단순포진각막염 1예

양현승,박호균,최상경,Hyun Seung Yang,Ho Gyun Park,Sangkyung Choi 대한안과학회 2011 대한안과학회지 Vol.52 No.9

Purpose: To report a case of herpetic keratitis after administration of two different prostaglandin analogues. Case summary: A 68-year-old female with a history of herpetic keratitis in her right eye after using latanoprost seven years previous presented with redness, mild ocular pain and tearing in the same eye. She had also been prescribed travoprost eye drops for both eyes for uncontrolled glaucoma one month earlier. The cornea in her right eye showed a dendritic epithelial defect with focal epithelial erosions. Travoprost treatment was discontinued, and the herpetic keratitis recovered completely in ten days with acyclovir ointment and oral agent. No further recurrence was observed in the following six months. J Korean Ophthalmol Soc 2011;52(9):1119-1122

거짓비늘증후군에서 개방각녹내장 병합 유무에 따른 전안부 소견과 생체 계측치에 대한 비교

구본혁(Bon Hyeok Gu),최상경(Sangkyung Choi) 대한안과학회 2018 대한안과학회지 Vol.59 No.11

목적: 거짓비늘증후군에서 개방각녹내장 병합 유무에 따른 전안부 소견과 생체 계측치들을 비교 분석하여 거짓비늘증후군에서 녹내장 발생과 관련된 인자들을 알아보고자 하였다. 대상과 방법: 본원에서 거짓비늘증후군으로 진단된 96명(115안)을 대상으로 하였으며, 단순거짓비늘증후군 64명(76안)과 녹내장 병합거짓비늘증후군 32명(39안)의 두 군으로 나누어 나이, 성별, 기저질환, 거짓비늘물질이 관찰된 부위 및 홍채의 변화, 핵백내장 정도, 산동 정도, 각막내피세포 수, 중심각막두께, 전방깊이, 안축장, 각막곡률, 안압을 비교하였다. 결과: 두 군 간 나이(p=0.694), 성별(p=0.161), 당뇨(p=0.440), 고혈압(p=0.238), 거짓비늘물질의 관찰 위치로 전낭, 동공연(p=0.700, 0.210), 홍채의 변화 양상으로 동공연 탈색소, 주름 소실(p=0.526, 0.708), 핵백내장 정도(p=0.617), 산동 정도(p=0.526), 중심각막두께(p=0.097), 전방깊이(p=0.283), 안축장(p=0.095), 수평, 수직 각막곡률(p=0.066, 0.306)에서 유의한 차이를 보이지 않았으며, 녹내장병합거짓비늘증후군에서 안압이 높고(p=0.026) 동공연의 막형성이 많으며(p=0.047), 각막내피세포 수의 감소(p=0.048)가 유의하게 관찰되었다. 결론: 거짓비늘증후군에서 개방각녹내장이 병합된 경우 높은 안압, 각막내피세포 수 감소, 동공연의 막형성 소견이 유의하게 비교 관찰되므로 이러한 변화 양상이 관찰될 때 녹내장 병합 가능성이 높음을 인지하여 경과관찰 시 세심한 주의가 필요할 것으로 사료된다. Purpose: To investigate the factors associated with glaucoma in patients with pseudoexfoliation syndrome by comparing features of the anterior segments and ocular biometry according to the presence or absence of open-angle glaucoma in pseudoexfoliation syndrome. Methods: We analyzed 96 patients (115 eyes) diagnosed as having pseudoexfoliation syndrome in this study. The patients were divided into two groups of simple pseudoexfoliation syndrome (64 patients, 76 eyes) and pseudoexfoliation glaucoma (32 patients, 39 eyes). We compared the age, sex, underlying disease, location of pseudoexfoliative material, iris change, degree of nuclear cataract, pupil dilatation, corneal endothelial cell counts, central corneal thickness, anterior chamber depth, axial length, corneal curvature, and intraocular pressure (IOP). Results: There were no significant differences between the two groups in terms of age (p = 0.694), sex (p = 0.161), diabetes (p = 0.440), hypertension (p = 0.238), pseudoexfoliative material observed in anterior capsule (p = 0.700), pupillary margin (p = 0.210), iris depigmentation (p = 0.526), pupillary ruff loss (p = 0.708), degree of nuclear cataract (p = 0.617), pupil dilatation (p = 0.526), central corneal thickness (p = 0.097), anterior chamber depth (p = 0.283), axial length (p = 0.095), or horizontal and vertical corneal curvature (p = 0.066 and 0.306, respectively). In pseudoexfoliation glaucoma, significantly higher IOP (p = 0.026), a high frequency of membrane formation (p = 0.047), and decreased corneal endothelial cell counts (p = 0.048) were observed. Conclusions: Pseudoexfoliation syndrome with open-angle glaucoma was shown to be associated with high IOP, decreased corneal endothelial cell counts, and a high frequency of membrane formation. Therefore, when such changes are observed in pseudoexfoliation syndrome patients, a higher risk of open-angle glaucoma should be recognized, and careful attentionis required accordingly.

QFD기법을 적용한 둔감탄약 기준 결정에 관한 연구

김태양(Taeyang KIM),유삼현(SamHyun YOO),김주희(Juhee KIM),이종우(Jongwoo Lee),최상경(Sangkyung CHOI) 육군사관학교 화랑대연구소 2014 한국군사학논집 Vol.70 No.3

둔감탄약은 포발사 환경에서 성능은 그대로 유지하면서 탄약의 폭발 취약성을 감소시켜 안전성을 향상시키고 수송, 저장 및 운용 시 사고나 피탄에 의한 피해를 최소화 시킬 수 있다. 이러한 둔감탄약 개발은 세계적인 추세로서 군 요구조건을 충족하면서 국외 수출경쟁력 확보를 위해 요구되고 있다. 본 연구에서는 이러한 선진국의 둔감탄약 시험 및 평가기준을 소개하고 한국군에 최적화된 둔감탄약의 기준을 제시하기 위해 도입한 QFD(=Quality Function Deployment) 기법의 적용방법을 자세히 소개하여 최종적으로 이를 바탕으로 한 한국군의 실정에 맞는 둔감탄약 기준을 설정하였다. Insensitive Munition(=IM) reduces the explosive weakness of munition with maintaining performances in the environment of discharge, which improves security and minimizes damages from accidents and being shot in case of transport, storage and operation. Development of IM has been the global trends, which was demanded to satisfy the requirement of military, prevent from the loss of non-battle and improve the export competitiveness, so that the necessity on the development of effective insensitive technique has been increased especially in power-enhanced munitions. In this study, we piled up voice of customer(=VOC) to set the standards for IM by using AHP(=Analytic Hierarchy Process), then end up with final standards for IM with QFD(=Quality Function Deployment).

무증상 경동맥협착에서 관찰되는 망막신경섬유층의 두께 감소

강태구(Tae Gu Kang),배희원(Heewon Bae),강민주(Min Ju Kang),최상경(Sangkyung Choi) 대한안과학회 2021 대한안과학회지 Vol.62 No.2

목적: 망막신경섬유층의 두께와 경동맥의 죽상경화성 협착과의 연관성에 대해 알아보고자 하였다. 대상과 방법: 빛간섭단층촬영을 이용한 망막신경섬유층의 측정 및 경동맥초음파검사를 1년 이내 시행한 106명을 대상으로 망막신경섬유층을 4분면으로 구분하여 각각의 두께 및 총 평균 두께와 경동맥의 내막두께, 플라크의 유무 및 협착 정도를 비교하였다. 또한, 망막신경섬유층의 총 두께와 경동맥의 죽상경화성 협착과의 상관관계를 확인하기 위해 나이, 총콜레스테롤 수치를 통제한 다중회귀분석(multiple regression analysis)을 실시하였다. 결과: 망막신경섬유층의 총 두께의 감소가 총경동맥플라크의 유무와 유의한 연관성을 보였으며(p=0.039), 총경동맥플라크 유무에 따른 두 군은 경동맥내막두께, 콜레스테롤 수치를 제외한 나이 및 혈관질환의 위험인자 간의 차이는 없었다. 선형회귀분석(linear univariate regression analysis)을 통하여 망막신경섬유층의 두께와 나이, 총 콜레스테롤 수치와의 관련성을 확인하였다. 또한, 다중회귀분석(linear multivariate regression analysis) 결과, 나이와 총 콜레스테롤 수치를 통제한 상황에서 총경동맥플라크의 유무와 망막신경섬유층 총 두께의 유의한 상관관계를 확인하였다(p=0.026). 결론: 빛간섭단층촬영을 이용한 망막신경섬유층의 측정을 통하여 안과적 질환을 배제한 망막신경섬유층의 두께 감소가 있을 경우 경동맥검사의 필요성을 고려해 볼 수 있다. Purpose: To investigate the relationship between retinal nerve fiber layer (RNFL) thickness and carotid artery stenosis (CAS). Methods: We retrospectively reviewed the medical records of 106 patients who underwent both optical coherence tomography to determine RNFL and carotid artery sonography within 1 year. The RNFL was divided into four quadrants, and each quadrant’s RNFL thickness and average thickness were compared with the artery endothelial thickness, the presence of plaque, and the degree of CAS. A multiple regression analysis was performed to assess the relationship between RNFL and CAS. Results: The presence of carotid artery plaque had a significant association with a decrease in the average RNFL thickness (p = 0.039). There was no statistically significant difference in age or risk factors associated with vascular disease, with the exception of carotid endothelial thickness and the total cholesterol level in the two groups, depending on the presence of total carotid plaque. RNFL thickness was confirmed to be related to age and total cholesterol levels using linear univariate regression analysis. In a multivariable linear regression analysis, with age and total cholesterol levels controlled, the presence of carotid artery plaque was significantly associated with a decrease in average RNFL thickness (p = 0.026). Conclusions: Asymptomatic CAS may be associated with a decrease in average RNFL thickness. In patients with decreased RNFL thickness without any ophthalmic diseases, carotid artery examination should be considered.

PBXN-109가 장전된 155 mm 고폭탄의 순폭현상 해석

김보훈(Bohoon Kim),김민성(Minsung Kim),양승호(Seungho Yang),오세안(Sean Oh),김진석(Jinseok Kim),최상경(Sangkyung Choi),여재익(Jai-ick Yoh) 한국추진공학회 2014 한국추진공학회지 Vol.18 No.5

Sympathetic detonation (SD) of high explosives occurs when a detonating donor initiates neighboring acceptors. The present study focuses on the hydrodynamic simulation of one-on-one sympathetic detonation of 155 mm charge filled with PBXN-109. Both unbuffered and buffered SD configurations are performed while changing the distance between each charge, in order to investigate the detonation sensitivity to a donor initiation. The cause of a SD is by a shock impact for the unbuffered case at a close range, while at a distant range, blast fragment penetration is the primary cause. The buffers can reduce the incident sensitivity to a SD by reducing the strengths of shock wave and impinging fragments.