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목근피가 CT105와 Ba로 유도된 Alzheimer's Disease 병태모델에 미치는 영향
최병만,정인철,이상룡 대한한방신경정신과학회 2004 동의신경정신과학회지 Vol.15 No.2
This research investigates the effect of the Hibiscus syriacus(HSS) on Alzheimer's disease. Specifically, the effects of the HSS extract on (1) IL-1β, IL-6, and TNF-α mRNA of PC-12 cells treated with LPS; (2) amyloid precursor proteins(APP), acetylcholinesterase(AChE), and glial fibrillary acidic protein(GFAP) mRNA of PC-12 cells treated with CT-105; (3) the AChE activity and the APP production of PC-12 cell treated with CT-105; (4) the behavior; (4) expression of IL-1β, TNF-α, IL-1β mRNA, TNF-α mRNA, and reactive oxygen species(ROS); (5) the infarction area of the hippocampus, and brain tissue injury in Alzheimer's diseased mice induced with βA were investigated. The results were summarized below ; 1. The HSS extract suppressed the expression of IL-1β, IL-6 and TNF-α mRNA in THP-1 cells treated with LPS. 2. The HSS extract suppressed the expression of APP, AChE, and GFAP mRNA in PC-12 cells treated with CT-105. 3. The HSS extract suppressed the AChE activity, and the production of APP significantly in PC-12 cells treated with CT-105. 4. For the HSS extract group a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer's disease induced by βA in the Morris water maze experiment, which measured stop-through latency, and distance movement-through latency. 5. The HSS extract suppressed the over-expression of IL-1β, TNF-α, IL-1β and TNF-α mRNA, CD68/GFAP, ROS in the mice with Alzheimer's disease induced by βA. 6. The HSS extract reduced the infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer's disease induced by βA. These results suggest that the HSS extract may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the HSS extract for Alzheimer's disease is suggested for future research
崔炳滿 大田工業大學 1990 한밭대학교 논문집 Vol.7 No.1
The early management theorists,conflict should be eliminated, and it was seen as destructive and it was role of management of to get rid the organization of them. The modern theorist's view of conflict differs from the early view in that it. 1. The absolute necessity of conflict. 2. conflict management to include stimulation as well as resolution method. 3. Conflict management as a major responsibility of all business administrators. This paper review the state of the art in the theory of organizational conflict. First a clear defination of causes and forms of conflicts within organizations are given. The paper then considers resolution and stimulation of intergroup conflict.
목근피(木槿皮)가 CT105와 ${\beta}A$로 유도된 Alzheimer's Disease 병태(病態) 모델에 미치는 영향
최병만,정인철,이상룡,Choi, Byung-Man,Jung, In-Chul,Lee, Sang-Ryong 대한한방신경정신과학회 2004 동의신경정신과학회지 Vol.15 No.2
This research investigates the effect of the Hibiscus syriacus(HSS) on Alzheimer's disease. Specifically, the effects of the HSS extract on (1) $IL-1{\beta}$, IL-6, and $TNF-{\alpha}$ mRNA of PC-12 cells treated with LPS; (2) amyloid precursor proteins(APP), acetylcholinesterase(AChE), and glial fibrillary acidic protein(GFAP) mRNA of PC-12 cells treated with CT-105; (3) the AChE activity and the APP production of PC-12 cell treated with CT-105; (4) the behavior; (4) expression of $IL-1{\beta}$, $TNF-{\alpha}$, $IL-1{\beta}$ mRNA, $TNF-{\alpha}$ mRNA, and reactive oxygen species(ROS); (5) the infarction area of the hippocampus, and brain tissue injury in Alzheimer's diseased mice induced with ${\beta}A$ were investigated. The results were summarized below ; 1. The HSS extract suppressed the expression of $IL-1{\beta}$, IL-6 and $TNF-{\alpha}$ mRNA in THP-l cells treated with LPS. 2. The HSS extract suppressed the expression of APP, AChE, and GFAP mRNA in PC-12 cells treated with CT-105. 3. The HSS extract suppressed the AChE activity, and the production of APP significantly in PC-12 cells treated with CT-105. 4. For the HSS extract group a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer's disease induced by ${\beta}A$ in the Morris water maze experiment, which measured stop-through latency, and distance movement-through latency. 5. The HSS extract suppressed the over-expression of $IL-1{\beta}$, $TNF-{\alpha}$, $IL-1{\beta}$ and $TNF-{\alpha}$ mRNA, CD68/GFAP, ROS in the mice with Alzheimer's disease induced by ${\beta}A$. 6. The HSS extract reduced the infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer's disease induced by ${\beta}A$. These results suggest that the HSS extract may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the HSS extract for Alzheimer's disease is suggested for future research.
한국 영화포스터 타이틀 로고의 표현방식에 관한 연구; 캘리그래피를 중심으로
최병만 디자인융복합학회 2006 디자인융복합연구 Vol.5 No.1
영화포스터는 한 장의 그림으로 영화의 내용과 이미지를 관객에게 가장 함축적으로 전달적이고 임펙트하게 전달하여야 한다. 캘리그래피는 이러한 영화의 내용을 적절하게 표현하고 효과적으로 전달하는 수단과 방법 중의 하나이다. 본 연구에서는 독특하고 강력한 디자인적 표현도구인 캘리그래피의 개념정리와 그 표현특성을 분석하고 한국 영화 타이틀로고 중, 캘리그래피를 사용한 예를 연구대상으로 선정하여 영화장르에 따라 쓰여진 타이틀로고와 표현유형를 사례조사를 통해 알아보았다. 또한 타이틀 로고에 활용된 캘리그래피의 표현도구 및 표현적 특징, 유형을 파악하였으며 영화 타이틀 로고의 개념과 제작방식에 따른 분류를 정리해 보았다. 마지막으로 캘리그래피의 제작방식과 표현방식을 유형별로 분석하여 캘리그래피의 보다 나은 발전적 방향을 제시하고자 한다. The movie poster as a piece of picture should be communicating with the audience to show the content of movie and image significantly. The Calligraphy is the ways and means to effectively represent and communicate the contents of a movie. This study analyze the concept arrangement Calligraphy of Unique and powerful design expression tool and Expression quality. In title logo in the Korea movie, selects research object of example which it uses Calligraphy and case study of Calligraphy from movie style and Expression pattern. Also, With the tie frame it was applied it grasped the expression tool and an expression feature and a pattern. It tried to arrange the title logo which with the movie tie frame it follows in intentional concept and production method. With this conclusion, I have a good prospect which is about the production analyze method of Calligraphy and expression about in the title logo in the movie.