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RISS 인기검색어
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- 저자 : 최명언 ( Eui Zu Yeo (검색결과 2 건)
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Effect of Dietary Lipid on Monoamine Oxidase Activity of Developing Rat Brain
여의주,최혜미,최명언,Yeo, Eui-Zu,Choi, Hay-Mie,Choi, Myung-Un 생화학분자생물학회 1985 한국생화학회지 Vol.18 No.2
식이 지방함량에 의한 성장기 뇌의 monamine oxidase(MAO) 활성도에 미치는 영향을 살펴보기 위해 옥수수 기름을 각각 10, 2, 0.5% 포함한 3종류의 식이를 임신한 Sprague Dawley종의 흰쥐에게 임신말기부터 제공했다. 수유기간중의 영향을 알아보기 위해 대조군(10% 옥수수 기름) 일부에 분만후 0.5% 결핍 식이를 섭취시켰으며, 또 0.5% 식이군의 일부에 이유후부터 10% 정상식이를 주어 회복 효과를 관찰하였다. 전 실험기간동안 임신 말기부터의 결핍 식이군의 MAO활성도는 대조군에 비해 유의적으로 감소했으나 분만후부터 0.5% 결핍식이를 제공한 군에서는 차이가 없었다. 그러나 serotonin을 기질로 하여 MAO type A 활성도를 살펴본 결과 분만후의 결핍에 의해서도 대조군과 유의적인 차이를 보여 주었다. 각 군의 뇌 mitochondria의 지질조성을 살펴본 결과 결핍군에서 대조군에 비해 phospholipids/cholesterol의 비가 유의적으로 낮았고 또한 membrane fluidity의 한 지표인 p/s의 비도 유의적으로 낮았다. 이들로부터 성장 초기에 지방함량을 조절한 식이에 의해 뇌 mitochondria의 지질 조성이 크게 변함을 관찰 할 수 있었고 이에 따라 그 외막에 결합된 MAO 활성도도 유의적인 영향을 받고 있음을 알 수 있었다. The effect of dietary lipid on monoamine oxidase (MAO) activity was examined by feeding pregnant Sprague Dawley rats with three kinds of experimental diets containing 10, 2, and 0.5% of corn oil. A part of control group rats was fed 0.5% deficient diet at birth in order to verify the lipid effect during the lactation period. Furthermore, a part of 0.5% diet groups was rehabilitated after weaning with the control diet for comparison. Throughout the experimental periods, MAO activities of the deficient groups were significantly lower than that of the control group except the MAO activity of the group fed 0.5% diet at brith (D-0.5B). When serotonin was used as substrate, however, the MAO-A activities of the D-0.5B group rats were also significantly lower than that of the control. The results of lipid compositions of each diet groups revealed that the phospholipid/cholesterol ratio of total lipid extracted from brain mitochondria showed significant differences between the control and the deficient groups. Likewise, the p/s ratio of deficient groups were also significantly lower than that of the control group. These observations, therefore, provide an evidence that the alteration of dietary lipid can affect the lipid composition of mitochondria and in consequence the dietary lipid influenced the activity of the membrane-bound MAO.
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식이중 지방함량이 성장기 쥐 뇌의 Monamine Oxidase 활성도에 미치는 영향
여의주,최혜미,최명언 ( Eui Zu Yeo,Hay Mie Choi,Myung Un Choi ) 생화학분자생물학회 1985 BMB Reports Vol.18 No.2
The effect of dietary lipid on monoamine oxidase (MAO) activity was examined by feeding pregnant Sprague Dawley rats with three kinds of experimental diets containing 10, 2, and 0.5% of corn oil. A part of control group rats was fed 0.5% deficient diet at birth in order to verify the lipid effect during the lactation period. Furthermore, a part of 0.5% diet groups was rehabilitated after weaning with the control diet for comparison. Throughout the experimental periods, MAO activities of the deficient groups were significantly lower than that of the control group except the MAO activity of the group fed 0.5% diet at brith (D-0.5B). When serotonin was used as substrate, however, the MAO-A activities of the D-0.5B group rats were also significantly lower than that of the control. The results of lipid compositions of each diet groups revealed that the phospholipid/cholesterol ratio of total lipid extracted from brain mitochondria showed significant differences between the control and the deficient groups. Likewise, the p/s ratio of deficient groups were also significantly lower than that of the control group. These observations, therefore, provide an evidence that the alteration of dietary lipid can affect the lipid composition of mitochondria and in consequence the dietary lipid influenced the activity of the membrane-bound MAO.
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