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그람양성세균에 대한 새로운 퀴놀론계 항균제 Zabofloxacin의 항균력
박희수(Hee Soo Park),최동락(Dong-Rack Choi),정지웅(Ji-Woong Jeong),정성지(Sung Ji Jung),최응칠(Eung-Chil Choi),곽진환(Jin-Hwan Kwak),김효현(Hyo-Hyun Kim) 大韓藥學會 2011 약학회지 Vol.55 No.1
Zabofloxacin is a novel broad spectrum fluoroquinolone with excellent anti-pneumococcal activity. We investigated the in vitro activity of zabofloxacin against clinical isolates of gram-positive bacteria and the in vivo activity against systemic infection in mice. Zabofloxacin was very active against gram-positive bacteria except QRSA (Quinolone-resistant S. aureus) and VRE(Vancomycin-resistant Enterococci). Especially, zabofloxacin was extremely potent against clinical isolates of Streptococci. Zabofloxacin was as active as gemifloxacin against systemic infection in mice. In view of its improved antibacterial activities against gram-positive bacteria and good pharmacokinetic profiles in animals, the clinical usefulness of zabofloxacin should be established by further studies.
새로운 Fluoronaphthyridinone계 항균제 DW286의 그람 양성세균에 대한 항균 활성
곽진환(Jin-Hwan Kwak),박희수(Hee Soo Park),정성지(Sung Ji Jung),정지웅(Ji-Woong Jeong),김요셉(Joseph Kim),최동락(Dong-Rack Choi),최응칠(Eung-Chil Choi) 대한약학회 2012 약학회지 Vol.56 No.5
In vitro antibacterial activity of DW286 was tested against recently collected clinical isolates of Gram-positive strains by the two fold agar dilution method. In vivo activity of DW286 was also determined against systemic infections in mice caused by Staphylococcus aureus. DW286 showed 16~64-fold more potent in vitro activities than ciprofloxacin against Gram-positive bacteria. Against systemic infection model caused by two S. aureus strains, one being methicillin-susceptible and the other methicillin-resistant, DW286 (ED50s, 0.16 mg/kg and 4.36 mg/kg, respectively) was more potent than gemifloxacin (1.37 mg/kg, 26.58 mg/kg, respectively).