레이저조사 후 망막에서의 디스인테그린 효과

최경식,김준순,박성희,Kyung Seek Choi,Joon Soon Kim,Song Hee Park 대한안과학회 2006 대한안과학회지 Vol.47 No.11

Purpose: To investigate weather an administrated inhibitor (disintegrin) of angiogenic factors inhibits the development of laser-induced experimental choroidal neovascularization (CNV) in rat model. Methods: Experimental CNV was induced by red argon laser photocoagulation in the eyes of 10 Brown Norway rats. The rats were divided into two groups, the disintegrin (flavoridin)-treated group and control group. Fundus photography and fluorescein angiography were performed to identify late leakage after two weeks of laser photocoagulation. Three days after fluorescein angiography, the expression of vascular endothelial growth factor (VEGF) was identified by immunohistochemical stain. Results: CNV-related fluorescein leakage appeared in forty-four (18 in the flavoridin-treated group, 26 in the control group) of 64 laser spots delivered to the 10 eyes that were tested at two weeks post-treatment. Expression of VEGF on laser-induced CNV lesions was reduced in the flavoridin-treated group. Conclusions: The results of this study suggest that disintegrin is an inhibitor of ocular angiogenesis; disintegrin reduced CNV in laser-induced experimental model. We expect that disintegrin may have a potent effect in age-related macular degeneration.

실험적으로 유발한 Bacillus 안내염에서 유리체강내 Ciprofloxacin의 치료효과

최경식 ( Kyung Seek Choi ),김준순 ( Joon Soon Kim ),남기룡 ( Ki Ryong Nam ) 대한안과학회 2002 대한안과학회지 Vol.43 No.5

칸디다 패혈증 환아에서의 안내 칸디다증

최경식(Kyung Seek Choi),김준순(Joon Soon Kim),남기룡(Ki Ryong Nam) 대한안과학회 2000 대한안과학회지 Vol.41 No.7

미숙아 3 세 때의 안과적 고찰

최경식(Kyung Seek Choi),한영근(Young Keun Han),박성희(Song Hee Park),신환호(Han Ho Shin) 대한안과학회 2000 대한안과학회지 Vol.41 No.4

백내장수술 중 낙하된 유리체내 수정체로 의뢰된 잔류수정체 제거술의 결과

최연주,최경식,이성진,이미리,Youn Joo Choi,MD,Kyung Seek Choi,MD,PhD,Sung Jin Lee,MD,PhD,Mi Ri Rhee,MD 대한안과학회 2012 대한안과학회지 Vol.53 No.1

Purpose: To assess the clinical features and outcomes of patients referred for management of dropped lens fragments during cataract surgery. Methods: The medical records of 22 eyes from 22 patients who were referred to our hospital to undergo pars plana vitrectomy (PPV) for management of dropped lens fragments after phacoemulsification surgery at private clinics were reviewed. Data including patient demographics, preoperative and postoperative visual acuity, factors associated with dropped lens fragment, and postoperative complications were recorded. The factors were compared between 2 patient groups: postoperative Snellen acuity of 0.5 or better and acuity less than 0.5. The statistical significances of differences in factors between the 2 groups were calculated. Results: The mean interval between cataract surgery and PPV was 2.6 ± 3.7 days. At the final examination, the mean postoperative acuity was 0.57 ± 0.20, and 16 eyes (72.7%) had a visual outcome of 0.5 or better. After excluding 7 eyes with other pre-existing ocular co-morbidities, 14 eyes (93.0%) achieved a final visual acuity of 0.5 or better. Multivariate analysis showed that the predictor for visual outcomes of 0.5 or better was absence of preoperative eye disease (p = 0.007). Complications after PPV included 2 (9.0%) cases of cystoid macular edema and 1 (4.5%) case of retinal detachment. Conclusions: Prompt referral and surgical management within 1 week for dropped lens fragments during cataract surgery may achieve a better visual outcome in cases with no pre-existing eye disease. J Korean Ophthalmol Soc 2012;53(1):68-75

망막분지정맥폐쇄환자에서 정맥폐쇄 위치에 따른 임상적 양상

박가희,최경식,Ka Hee Park,MD,Kyung Seek Choi,MD 대한안과학회 2013 대한안과학회지 Vol.54 No.8

Purpose: To evaluate clinical patterns according to the occlusion site in patients with branch retinal vein occlusion. Methods: Ninety-one branch retinal vein occlusion patients were divided into 4 groups according to the occlusion site based on the description by Duke-Elder and Wybar: Papillary retinal vein occlusion group (group A), main retinal vein occlusion group (group B), minor retinal vein occlusion group (group C), and retinal venule occlusion group (group D). The following factors were analyzed retrospectively: baseline/final visual acuity, visual improvement, macular thickness, and macular circulatory states. Results: The macular thickness (μm) was 575.33 ± 178.44 in group A, 511.92 ± 218.02 in group B, 397.21 ± 144.51 in group C, and 336.68 ± 120.55 in group D. The retinal ischemic area (DD) was 22.00 ± 13.28 in group A, 18.26 ± 10.12 in group B, 12.52 ± 10.52 in group C, and 12.36 ± 11.92 in group D, which was found to be significantly greater in the group with the higher branch occlusion site (p < 0.05). However, visual acuity, macular circulatory states and other clinical characteristics were not significantly different. Conclusions: Occlusion site is a relating factor for retinal ischemic area and macular thickness in patients with Branch retinal vein occlussion, but which is not a prognostic factor for final visual acuity.

당뇨황반부종의 치료: 비교 연구

이용준,최경식,이성진,Yong Jun Lee,MD,Kyung Seek Choi,MD,PhD,Sung Jin Lee,MD,PhD 대한안과학회 2010 대한안과학회지 Vol.51 No.6

Purpose: To compare the effect and complications of treatments for diabetic macular edema. Methods: Literature review using the Korean medical database and the Korean Ophthalmological Society database was performed. Studies used consisted of patients with diabetic macular edema, comparing intravitreal triamcinolone acetonide (IVTA) injection with posterior subtenon triamcinolone acetonide (STTA) injection or intravitreal bevacizumab (IVB) injection, according to visual acuity (VA) outcomes, central macular thickness (CMT), and intraocular pressure (IOP) at 1, 3, and 6 months. Results: In the three studies comparing IVTA injection with STTA injection, IVTA injection demonstrated greater improvement in VA at 1 month and CMT at 6 months. The patients who received IVTA injection had significantly higher IOP at 3 months. In the three studies comparing IVTA injection with IVB injection, IVTA injection demonstrated greater improvement in VA at 3 months and CMT at 6 months. Conclusions: The functional and anatomical improvements are achieved by IVTA injection, STTA injection, and IVB injection for diabetic macular edema, and the effect of IVTA injection is more prominent than other injection types with longer duration. J Korean Ophthalmol Soc 2010;51(6):849-859

신생혈관 녹내장이 합병된 유리체출혈 환자에서 유리체절제술과 아메브밸브삽입술

문다루치,최경식,이성진,하승주,Da Ru Chi Moon,Kyung Seek Choi,Sung Jin Lee,Seung Joo Ha 대한안과학회 2012 대한안과학회지 Vol.53 No.6

Purpose: To compare the surgical outcomes between sequential -and simultaneous combined vitrectomy and Ahmed valve implantation (AVI) in neovascular glaucoma (NVG) patients with vitreous hemorrhage. Methods: The medical records of 22 eyes of 22 patients, who had NVG with vitreous hemorrhage treated with vitrectomy and AVI, were retrospectively reviewed. Surgical success was defined as 6 mm Hg ≤ IOP ≤ 21 mm Hg, with or without the use of antiglaucoma medications and failure was defined as cases that had no light perception during the study period and which required additional surgery. The authors of the present study evaluated the surgical success rates and factors affecting surgical success between sequential and simultaneous combined vitrectomy and AVI. Results: The cumulative surgical success rate by the Kaplan-Meier survival analysis was 45% in sequential combined vitrectomy and AVI (group1), and 18% in combined vitrectomy and AVI (group 2), at 1 year, a significant difference. Preoperative panretinal photocoagulation was related to surgical success rate by Cox’s regression model analysis. Conclusions: Simultaneous combined vitrectomy and AVI is considered as a primary procedure in a patient who has NVG with vitreous hemorrhage. Panretinal photocoagulation in the preoperative periods, is thought to increase the surgical success rate. J Korean Ophthalmol Soc 2012;53(6):801-806

유리체절제술과 가스주입술 후 체위에 따른 안압의 변화

문찬희,최경식,이미리,이성진,Chan Hee Moon,Kyung Seek Choi,Mi Ri Rhee,Sung Jin Lee 대한안과학회 2013 대한안과학회지 Vol.54 No.1

Purpose: To assess the influence of body position on intraocular pressure (IOP) in patients who underwent vitrectomy and intraocular gas tamponade. Methods: Patients who did not undergo any surgery were defined as Group 1. The remaining patients were divided into 3 groups according to the surgery performed (Group 2; cataract surgery, Group 3; vitrectomy and cataract surgery, Group 4; vitrectomy with intraocular gas tamponade and cataract surgery). IOP was measured by a non-contact tonometer, Goldmann applanation tonometer, and Tono-Pen in the sitting, supine, and prone positions. Results: The difference of IOP measured in the sitting position among the 4 groups was not significant. IOP was significantly elevated by 2.04 mm Hg on average when the posture was changed from sitting to supine or prone in all 4 groups. The IOP discrepancy between supine and sitting positions was significantly greater in group 4 by 3.61 mm Hg than the other groups (p = 0.003, ANOVA test). The IOP difference between the prone and sitting position was also significantly higher in group 4 by 3.82 mm Hg than the other groups (p = 0.001, ANOVA test). Conclusions: The patients with vitrectomized gas tamponade eyes had a mean IOP increase of 3.82 mm Hg when the position was changed from sitting to prone. When performing vitrectomy and intraocular gas tamponade on patients in the prone position, an IOP elevation should be monitored thoroughly.

망막분지정맥폐쇄에 합병된 황반부종에서 유리체강내 베바시주맙 주입술이 삶의 질에 미치는 영향

김지욱,최경식,이미리,이성진,Jee Wook Kim,MD,Kyung Seek Choi,MD,PhD,Mi Ri Rhee,MD,Sung Jin Lee,MD,PhD 대한안과학회 2012 대한안과학회지 Vol.53 No.10

Purpose: To evaluate the impact of intravitreal bevacizumab injection on visual function and vision-related quality of life (VR-QOL) in patients with branch retinal vein occlusion (BRVO) using the Korean version of the National Eye Institute Visual Function Questionnaire 25 (K-NEI-VFQ-25). Methods: This study included 32 normal control subjects and 32 patients with BRVO. The Korean version of NEI-VFQ-25 was answered by the patients with BRVO before and 3 months after intravitreal bevacizumab injection, as well as by normal control subjects. Clinical data were collected, including central macular thickness (CMT), total macular volume (TMV) (using time-domain optical coherence tomography [OCT]), and best corrected visual acuity (BCVA). Results: Visual acuity, CMT, and TMV significantly improved 3 months after intravitreal bevacizumab injections. No bevacizumab- related systemic or ocular adverse effects following intravitreal drug injections were observed. Significant improvement in the VFQ-25 composite score was observed in patients with BRVO. Subscale scores, including general vision, near activities, distance activities, social functioning, mental health, role difficulties, dependency, and peripheral vision, improved after injection. However, subscale scores regarding general health, ocular pain, driving, and color vision did not improve significantly. Conclusions: Intravitreal bevacizumab injection appears to be an effective treatment for visual function, as well as VR-QOL in macular edema secondary to BRVO. However, improvement of driving function and color vision appears to require a longer recovery time than visual function. J Korean Ophthalmol Soc 2012;53(10):1465-1471