http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 최경묵(Kyung Muk Choi) (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
-
김용현(Yong Hyun Kim),이은종(Eun Jong Lee),최경묵(Kyung Muk Choi),김상진(Sang Jin Kim),유재명(Jae Myung Yoo),백세현(Sei Hyun Baik),최동섭(Dong Seop Choi) 대한내과학회 1995 대한내과학회지 Vol.48 No.5
Objectives: Primary aldosteronism is one of major causes of secondary hypertension that is characterized by hypertension with hypokalemia, suppressed plasma renin activity and elevated plasma aldosterone level due to excessive secretion of aldosterone from the adrenal. In Korea the first case was reported in 1968 and a clinical study of 10 cases was described in 1983. More cases of primary aldosteronism would have been diagnosed with the advanced method of measuring hormone level and abdominal CT scanning, but we cant find out more cases in the Korean literatures till now. So we performed this clinical study to evaluate systematic diagnostic method and effective treatment modality. Methods: We compared the clinical and laboratory characteristics and treatment outcomes between aldosterone producing adenoma and idiopathic hyperplasia in 15 cases of primary aldosteronism that were diagnosed and followed at Korea University Hospital from 1986 to 1993. Results: 10 cases out of 11 in which abdominal CT scan showed adrenal mass were confirmed as adenoma and remaining 1 case was diagnosed as hyperplasia pathologically, so total 5 cases of hyperplasia were diagnosed finally. Plasma aldosterone concentrations after 4 hours upright posture were increased in all 4 cases of bilateral hyperplasia and decreased or unchanged in 6 adenoma cases out of 7. The case number 6 patient showed increased plasma aldosterone concentration after upright posture in spite of adrenal mass lesion on abdominal CT scan and was diagnosed finally as renin-responsive adenom. 5 adenoma cases out of 10 are maintained normotensive state without medication and remaining 5 cases are taking antihypertensive medication Conclusion: After the diagnosis of primary aldosteronism by measurements of plasma renin activity and aldosterone concentration in hypertensive patient with hypokalemia, the differential diagnosis between aldosterone-producing adenoma and bilateral adrenocortical hyperplasia using upright posture test and abdominal CT scan will be helpful to determine the treatment modality. But occasionally, futher detailed diagnostic study is necessary in cases of small aldosterone producing adenoma that is not detected on abdominal CT scan and in cases of renin-responsive adenoma or glucocorticoid-suppressible aldosteronism.
-
갑상선 악성종양 및 양성종양에서 Fra - 1 표현에 대한 연구
김용현(Youg Hyun Kim),오정헌(Jeong Heon Oh),김난희(Nan Hee Kim),최경묵(Kyung Muk Choi),김상진(Sang Jin Kim),백세현(Sei Hyun Baik),최동섭(Dong Seop Choi),이응석(Eung Seok Lee) 대한내과학회 2000 대한내과학회지 Vol.59 No.4
Background : Differential diagnosis of thyroid nodule is important in deciding treatment modality and fine needle aspiration is a good method to do so. But, sometimes, it has limitation in use because of inadequate test material and difficulty in interpreting it. Among the study of oncogene and tumor suppresor gene on the origin of thyroid tumor, expression of Fra-1, one of AP-1 system, is increased in thyroid neoplasm. So there is a possibility that it would be used as a method for differential diagnosis of thyroid nodule. We tried to know whether presence or absence of Fra-1 expression can be used as a diagnostic method in differential diagnosis of thyroid nodule using immuno- histochemical(IHC) staining method.Methods : In 4 types of thyroid tumor that was confirmed by histologic diagnosis after operation(30 cases of papillary cancer, 10 cases of follicular cancer, 16 cases of follicular adenoma, 18 cases of adenomatous goiter), IHC staining method was performed to evaluate the expression of Fra-1.Results : In papillary and follicular thyroid cancer, the expression of Fra-1 was stronger than benign thyroid tumor, but there was no difference in Fra-1 expression between two types of carcinoma. Weak expression of Fra-1 was observed in all cases of follicular adenoma, and it was also weakly expressed in 6 out 18 cases of adenomatous goiter. Conclusion : The expression of Fra-1 was stronger in thyroid cancer than in benign thyroid adenoma, but it was impossible to differentiate thyroid cancer from benign thyroid adenoma by the presence or absence of Fra-1 expression using IHC staining method.(Korean J Med 59:398-403, 2000)
-
-
저용량 스트렙토조토신 유발 당뇨병 생쥐에서 인슐린 및 비타민 E 투여가 췌장 소도세포의 세포자연사(Apoptosis)에 미치는 영향
김상진,이응석,김난희,김용현,최동섭,백세현,이민철,오정헌,최경묵 대한당뇨병학회 1999 Diabetes and Metabolism Journal Vol.23 No.6
Background : Type 1 diabetes mellitus results from irreversible loss of β cells in pancreatic islet. It is generally known that abnormal MHC expression and interaction of variable cytokines play a role in β cell death, but the precise mechanism of β cell death is unknown. Apoptosis is a physiological form of cell death and can play an important role in β cell death in experimental diabetic animal models. Thus, in insulin and vitamin E treated LDSD mice and streptozotocin treated control mice. We attempted to comparing the levels of blood glucose (BG), the degree of insulitis, and number of apoptotic cells. Our study goal was to understand inhibition of apoptosis which thought to play an important mechanism in reducing the degree of hyperglycemia and insulitis. Methods: In 3 LDSD mice groups (group 1: control group with streptozotocin only, group 2: streptozotocin plus insulin, group 3: streptozotocin plus vitamin E), the effects of insulin and vitamin E on the blood glucose levels and the degree of insulitis were evaluated. The number of apoptotic cells of pancreatic islet was compared using double staining immunohistochemical method. Results : The levels of BG, degree of insulitis and the rate of apoptosis of pancreatic islet cells were decreased in insulin and vitamin E treated groups when compared to the control group. There was no difference in number of apoptotic cells between insulin and vitamin E treated group, but levels of BG and degree of insulitis were higher in vitamin E treated group than insulin treated group as time elapsed. Conclusion : Insulin and vitamin E can decrease the elevation of BG and the degree of insulitis via inhibition of apoptosis in LDSD mice.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
