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천태종,노병인 대한의진균학회 1999 대한의진균학회지 Vol.4 No.2
Chronic mucocutaneous candidiasis (CMCC) is a general term used to denote a complex group of disorders characterized by a recurrent and persistent infection of the skin, mucous membranes and nails with organism of the genus Candida, most frequently Candida albicans. It is often associated with an endocrinopathy and cell mediated immunopathy. CMCC is not a single disease entity, but rather a final common pathway for multiple predisposing abnormalities of the immune system that ranges from severe, life-threatening immunodeficiency syndromes to subtle deficiencies, especially of cell mediated immunity. Conditions that have been associated with CMCC include; candida esophagitis or laryngitis, endocrinopathies(usually hypoparathyroidism, hypoadrenalism, hypothyroidism), circulating autoimmune antibodies, diabetes mellitus, vitiligo with antibodies to melanocytes, iron deficiency, chronic active hepatitis, pernicious anemia, malabsorption, alopecia totalis, dental enamel dysplasia, keratoconjunctivitis, pulmonary fibrosis, KID syndrome (keratitis, ichthyosis, and deafness), and recurrent pyogenic, viral or other fungal infections. When CMCC first appears in adulthood, it is often associated with a thymoma. There is virtually no propensity for disseminated, visceral candidiasis. A suitable clinical classification of the major subtypes of CMCC was described by Lehner and Wells et al into six groups. Kirkpatrick et al found the mean age of onset of CMCC to be 3 years and both boys and girls are affected equally. We review CMCC and 5 reported CMCC cases in the dermatologic literatures in Korea. [Kor J Med Mycol 4(2): 104-108]
천태종(Tae Jong Chun),이강석(Kang Seok Lee),서성준(Seong Jun Seo),김명남(Myung Nam Kim),홍창권(Chang Kwun Hong),노병인(Byung In Ro) 대한피부과학회 1999 대한피부과학회지 Vol.37 No.10
N/A Background : Prick test is most frequently used in clinical procedures because its simplicity and safety of application and better correlation with clinical history as well as specificity and high reproducibility. The chemiluminescent assay(CLA) is a new in vitro non-radioactive modification of radioallergosorbent test(RAST). The CLA permits quick, simultaneous detection of total and specific IgE in human serum. The CLA has shown good sensitivity, specificity, and a good correlation with the RAST and skin prick test. Objective : The purpose of this study was to find causative allergens and to evaluate the clinical significance of CLA comparing the results of the CLA with those of the prick test in dermatologic outpatients. Methods : We performed the prick test with 51 allergens(Bencard Ltd. Brentford, England) in 448 patients, and CLA with 35 allergens(Boehringer mannheim Korea. green cross inc.) in 280 patients with dermatologic disease. Results : 1. The positive reaction rate was highest in third decade and decreased over the age of 40 in prick and CLA. 2. The positive reaction rate of prick test(52.8%) was higher than that of CLA(25.0%). 3. The positive reaction rate to single allergens and compound allergens was 14.2% and 38.6% in the prick test and 2.5% and 22.5% in the CLA respectively. 4. In the prick test, the positive alleragens, in descending order, were House dust 114(25.4%), D. farinae 88(19.6%), D. pteronyssinus 79(17.6%), Mixed inhalants 61(13.6%), and Threshing 47(10.5%). In the CLA Thistle 35(12.5%), Dandelion 31(11.1%), D. farinae 30(10.7%), D. pteronyssinus 29(10.4%), and Cat fur 12(4.3%). 5. The results of the CLA to common 2 allergens showed a concordance rate of 84.6%, sensitivity of 58.9%, and specificity of 86.1% compared with those of prick test. Conclusion : CLA may be a useful alternative method and shows a good correlation with the prick test. Combination of the two method results in a high diagnostic accuracy for the cause of allergic disease. (Korean J Dermatol 1999 : 37(10): 1450∼1456)
천태종(Tae Jong Chun),노성욱(Sung Wook Ro),서성준(Seong Jun Seo),송계용(Kye Yong Song),홍창권(Chang Kwun Hong),노병인(Byung In Ro) 대한피부과학회 1999 대한피부과학회지 Vol.37 No.9
We report a case of cutaneous B cell lymphoma in a 65-year-old male who had several bizarre shaped erythematous to brownish plaques on the both shins for 2 months. An abdominal CT scan revealed gastrohepatic ligament, retroperioneal, mesenteric and bilateral external iliac lymphadenopathies. Histologic examinations revealed diffuse dense infiltration of the large arypical cells with vesicular nucleus and prominent nucleoli in the entire dermis. They showed a positiver reaction to the LCA, CD20 and kappa light chain in the immunohistochemical study, suggesting that these neoplastic lymphoid cells are B cell linage. We treated hi, with COPBLAM-V regimen. In the course of treatment, new skin lesions developed on both upper arms and herpes zoster on the left thigh. So we changed the regimen into IMVP-16. No relapses have been found up to the present date for 9 months. (Korean J Dermatol 1999;37(9) : 1330∼1334)
피부 편평세포암과 기저세포암에서 각질형성세포 성장 인자 mRNA의 발현
노병인,홍창권,황규광,서성준,천태종 대한피부과학회 2000 대한피부과학회지 Vol.38 No.3
Background:Human keratinocyte growth factor(KGF) is an epithelial cell specific mitogen which is secreted by normal stromal fibroblast. In skin, KGF has been shown to stimulate keratinocyte proliferation. Objective:In the present study, we sought to determine whether KGF is expressed in human squamous and basal cell carcinoma. Methods:Using a reverse transcriptase polymerase chain reaction(RT-PCR), we examined the expression of KGF mRNA in normal and cancerous human skin tissues. Results: 1. The 583 bp KGF specific PCR product was observed in normal human cultured fibroblast, but no PCR product was seen in normal human cultured keratinocyte, A431, PAM212, HaCaT, and XB2 cell lines by RT-PCR of KGF mRNA using KGF-specific primer as visualized on an ethidium bromide stained agarose gel. 2. The 583 bp KGF specific PCR product was observed in the normal human dermis, squamous and basal cell carcinoma samples. 3. All three squamous and basal cell carcinoma samples revealed significant overexpression of KGF mRNA transcript in comparison with normal skin tissue. Conclusion:These results suggest that KGF mRNA level may be elevated in squamous and basal cell carcinoma and elevated KGF may enhance cellular proliferation of these skin carcinoma.