http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Bl6 Melanoma세포에서 Protein Kinase억제제들이 Cyclic AMP 경로를 통한 멜라닌 생성에 미치는 영향
차상복(Sang Bok Cha),조남영(Nam Young Cho),윤미연(Mi Yun Yoon),임혜원(Hye Won Lim),김경원(Kyoung Won Kim),박영미(Young Mi Park),이지윤(Ji Yun Lee),이진희(Jin Hee Lee),김창종(Chang Jong Kim),심상수(Sang Soo Sim) 대한약학회 2003 약학회지 Vol.47 No.1
To investigate the effect of protein klnase on melanin production via CAMP-dependent pathway, we measured the melanin amount and tyrosinase activity in Bl6 melanoma cells stimulated by alpha-melanocyte stimulating hormone (MSH), forskolin and 8-Br-Camp MSH, forskolin and 8-Br-Camp significantly increased both melanin production and tyrosinase activity in Bl6 cells. Melanin production and tyrosinase activity by MSH are significantly inhibited by cyclic AMP-dependent protein kinase inhibitor (KT5720) and protein kinase C down-regulation treated with PMA. Bisindolmaleimide (1μM), protein kinase C inhibitor, significantly inhibited melanin production and tyrosinase activity stimulated by MSH, for-skolin and 8-Br-Camp with the following order of potency: MSH>forskolin>8-Br-Camp. Tyrosine kinase inhibitor, genistein and DHC, significantly inhibited both, but the inhibitory effect was more potent in 8-Br-Camp-stimulated Bl6 cells than MSH-stimulated cells. NFkB inhibitor (parthenolide) significantly inhibited melanin production and tyrosinase activity. Neither melanin production nor tyrosinase activity induced by MSH, forskolin and 8-Br-Camp were affected by KN-62 (calm-odulin-dependent protein kinase II inhibitor), PD098059 (mitogen-activated protein kinase inhibitor, MAPKK) and worthmannin (phosphatidylinositol 3-kinase inhibitor). These results suggest that both protein klnase C and tyrosine kinase are involved in melanin production by cyclic AMP-dependent pathway and NFrB pathway may play an important role in cyclic AMP-dependent melanin production in Bl6 melanoma cells.
차상복(Sang Bok Cha),송춘익(Choon Eck Song),양철우(Chul Woo Yang),최규용(Kyu Young Choi),성기열(Ki Yul Sung),이안희(Ah Hee Lee),박승만(Seung Man Park) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.2
61 year-old man with malnutrition and ascite was diagnosed to have Menetrier's disease by gastrofiberscopy and UGIS. Work-up showed classic menetriers disease with enlarged gastric rugae and hypoalbuminemia due to protein-losing gastropathy. 50 days after medical conservative treatement, total gastrectomy was performed in order to improve hypoalbuminemia. Microscopically there was a increased number of mucous cell involving the parietal and chief cell. We consider it mixed mucous-glandular cell type hyperplasia by Mings classification. The pathogenesis and pathophysiology of the disease are poorly understood. Indeed, there is sti]1 controversy regarding its classification, cause and management. A brief review of classification, etiology, pathophysiology, classical pictures and management of Menetriers disease is presented.
간 , 담도 및 췌장 : 악성 종양과 간경변에 동반된 복수의 Lipid 분석의 의미
차상복(Sang Bok Cha),김부성(Boo Sung Kim),박두호(Doo Ho Park),이창돈(Chang Don Lee),최상욱(Sang wook Choi),권혁호(Hyuk Ho Kwon),이종욱(Jong Wook Lee),김종진(Jong Jin Kim) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.2
N/A To evaluate the difference of ascitic lipids in liver cirrhosis and cancer, the concentrations of phosphosipids, cholesterol triglycerides and total protein were studied in 30 patients with liver cirrhosis, 22 patients with various neoplasms. The ascitic lipids, especially in phospholipids, and total protein were higher in the group with ma1ignant neoplasm (phospholipids: 21.94+-16.2 vs 48.76+-26,08 mg/dl, cholesterol: 19.24+-18.26 vs 50. 33+-36.09 mg/dl, triglycerides: 21.70+-11.76 vs 33.00+-16.50 mg/dl, total protein; 1.04+-0.45 vs 2.70+-1.47 gmjdl). The best discrimination values were 35 mg/dl for phopholipids, 28 mg/dl for cholesterol, 29.5 mg/ dl for triglycerides and 2.O gm/dl for protein. Application of these cut off points revealed on efficiency of 80.4% for phospholipids, 77.5% for cholesterol, 71.8% for triglycerides and 80.8% for protein. We conclude that ascitic lipids offers an excellent diagnostic discrimination between cirrhosis and malignant neoplasms, but further investigations are needed in tuberculosis.
여러 감염증에 대한 Trimehoprim-sulphamethoxazole(Bactrim)의 치료경험
전종휘,차상복 최신의학사 1971 最新醫學 Vol.14 No.7
The clinical efficacy of a new antimicrobial, TM-SMZ(Bactrim) in the treatment of various disease: was evaluated in the Dept. of Internal Med., ST. MARY's Hospital during the period from July 1970, to Feb. 1971. Bacterial cultures and sensitivity tests to antimicrobial agents were performed, in whitcl 525 strains of various bacterias were tested on sensitivity test and 47 systemic cases including Typhok fever(20 cases) were observed on therapeutic efficacy_ In this study, TM-SMZ(Bactrim) was the most sensitive agent to bacteria isolated in variou; infections and their sensitivity rates were as follows: Bactrim. ...82%, Erythromycin ...81%, Kanamyir 71%, Chlortetracycline ...64%, Chloramphenicol "56%, Amphicillin...56%, Oxytetracycline ...47%, Strept?omycin ???38%, Penicillin ???24%(Tab.2), (Erythromycin is rare by used recently in this area) Clinical study and its result was obtained on therapeutic efficacy with TM-SMZ in 27 cases of variou: infections including mainly 9 cases of urinary-and 8 cases of biliary infections and 20 cases of Typhoic fever. Overall success rate of Bactrim -therapy was 75%, (exellent and good effect) and average perioc of time taken for defevescence in 20 Typhoid cases was 5. 8 days. Among these, 2 cases were readmittee due to relapse. There were only 2 cases of side reaction(skin rash) of the drug among these 47 case: of this clinical observation. This new antimicrobial agent; TM-SMZ(Bactrim) is, therefore, an effective drug to various bacteria. infections of gram positive as well as gram negative bacteria, and disclosed that it is an antimicrobia agent of broad spectrum.