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진태은,장미애,김현정,최유미,정성권,박명규 한국분자세포생물학회 2008 Molecules and cells Vol.26 No.3
Corticotropin releasing factor (CRF) mediates various responses to stress through CRF receptors 1 and 2. CRF receptor 2 has two forms, 2alpha and 2beta each of which appears to have distinct roles. Here we used dopaminergic neuron-derived MN9D cells to investigate the function of CRF receptor 2 in dopamine neurons. We found that n-butyrate, a histone deacetylase inhibitor, induced MN9D cell differentiation and increased gene expression of all CRF receptors. CRF receptor 2beta was minimally expressed in MN9D cells; however, its expression dramatically increased during differentiation. CRF receptor 2beta expression levels appeared to correlate with neurite outgrowth, suggesting CRF receptor 2beta involvement in neuronal differentiation. To validate this statement, we made a CRF receptor 2beta-overexpressing MN9D/CRFR2 stable cell line. This cell line showed robust neurite outgrowth and GAP43 overexpression, together with MEK and ERK activation, suggesting MN9D cell neuronal differentiation. From these results, we conclude that CRF receptor 2beta plays an important role in MN9D cell differentiation by activating the MEK/ERK signaling pathway.
비균질 구배기능 계면영역을 고려한 적층 만무한체의 동일선상 복수균열 해석
진태은,최형집,이강용,Jin, Tae-Eun,Choe, Hyung-Jip,Lee, Kang-Yong 대한기계학회 1996 大韓機械學會論文集A Vol.20 No.4
The plane elasticity problem of collinear cracks in a layered medium is investigated. The medium is modeled as bonded structure constituted from a surface layer and a semi-infinite substrate. Along the bond line between the two dissimilar homegeneous constituents, it is assumed that as interfacial zone having the functionally graded, nonhomogeneous elastic modulus exists. The layered medium contains three collinear cracks, one in each constituent material oriented perpendicular to the nominal interfaces. The stiffness matrix formulation is utilized and a set of homogeneous conditions relevant to the given problem is readily satisfied. The proposed mixed boundary value problem is then represented in the form of a system of integral equations with Cauchy-type singular kernels. The stress intensity factors are defined from the crack-tip stress fields possessing the standard square-root singular behavior. The resulting values of stress intensity factors mainly address the interactions among the cracks for various crack sizes and material combinations.