T102C Polymorphism of the 5-HT<SUB>2A</SUB> Receptor Gene is not Associated with Homicide in Male Schizophrenics

Ik-Seung Chee(지익성),Seung-Keun Wang(왕성근),Sun-Woo Lee(이선우),Jeong-Lan Kim(김정란),Young-Ho Lee(이영호),Sang-Sup Choi(최상섭),Chung-Suk Lee(이충숙) 대한생물치료정신의학회 2007 생물치료정신의학 Vol.13 No.2

목적:세로토닌체계의 변화가 정신분열병이나 폭력행동과 관련이 있다고 알려져 있다. 저자 등은 5-HT2A 수용체 유전자 다형성(T102C)이 살인을 범한 남성 정신분열병과 관련이 있는지 알아보기 위하여 본 연구를 시행하였다. 방법:살인을 범한 정신분열병 환자 105명, 비폭력 정신분열병 환자 102명, 정상 대조군 104명을 대상으로 중합효소 연쇄반응을 이용하여 5-HT<SUB>2A</SUB> 수용체 유전자 다형성(T102C)의 유전자형과 대립유전자의 빈도를 비교하였다. 모든 대상은 한국인 남자였다. 결과:살인을 범한 정신분열병군, 비폭력 정신분열병군, 정상대조군을 비교한 결과 세군간에 유전자형(χ²=8.090, df=4, p=0.088)이나 대립유전자(χ²=2.880, df=2, p=0.237)에서 통계적인 차이가 없었다. 또한 살인을 범한 정신분열병군과 비폭력 정신분열병군, 살인을 범한 정신분열병군과 정상 대조군, 그리고 비폭력 정신분열병군과 정상 대조군을 각각 비교하였을 때도 유전자형과 대립유전자에서 통계적인 차이가 없었다. 결론:이러한 결과는 5-HT<SUB>2A</SUB> 수용체 유전자 다형성(T102C)이 남성 정신분열병환자의 살인행동과는 관련이 없음을 제시한다. 향후 살인을 범한 여성정신분열병환자와 살인을 범한 일반 범죄인을 포함한 연구가 필요할 것으로 사료된다.

한국인에서 연령 증가에 따른 분노와 공격성의 변화

박재상(Jae-Sang Park),임채성(Chae-Sung Im),김태성(Tae-Sung Kim),왕성근(Seong-Keun Wang),지익성(Ik-Seung Chee),김정란(Jeong-Lan Kim) 대한노인정신의학회 2010 노인정신의학 Vol.14 No.2

Objectives : This study was to investigate the trends in anger and aggression with aging in Korean population aged from twenties to eighties. Methods : Two hundreds ninety-five subjects included, ranged 22 to 92 years old. All subject participate in a clinical interview with psychiatrists who use the MINI (Mini international Neuropsychiatric Interview) to diagnosis psychiatric disorders, and were not any psychiatric disorders. Results : In elderly group, the scores of Trait anger, Anger expression, and totol of STAXI were higher than adult group, where as the scores of State anger of STAXI, Hostility of AQ, and Disturbances, Embarrassing, Unpleasant circumstances, and total of RI were higher in adult group. Trait anger and Anger expression were shown trends to increase with age. On the other hands, State anger, Hostility, and Reaction to external stimuli were shown trends to decrease with age. Conclusion : The reaction to anger situation and aggression decrease with age, although anger increase with age. Various factor, such as defense mechanism may affect on aggressive expression and response. There will be needed to investigate associated factors between anger and aggression.

국내 대학병원 공황장애 환자들의 임상적 특징에 대한 연구 : 다기관, 후향적 연구

오재영,이재헌,한상우,지익성,구본훈,우종민,양종철,김민숙,이상혁,허정윤,유범희,Oh, Jae-Young,Lee, Jae-Hon,Han, Sang-Woo,Chee, Ik-Seung,Koo, Bon Hoon,Woo, Jong Min,Yang, Jong-Chul,Gim, Min-Sook,Lee, Sang Hyuk,Heo, Jung-Yoon,Yu, Bum-Hee 대한불안의학회 2014 대한불안의학회지 Vol.10 No.1

Objective : Despite the high prevalence and clinical importance of panic disorder, studies on the clinical characteristics and course of panic disorder are relatively rare. This study is a multi-center, and retrospective study to examine the clinical characteristics and course of Korean panic disorder patients who visit university hospital. Methods : The study subjects were panic disorder patients who had visited the psychiatric outpatient clinics of 8 university hospitals in South Korea from January to December in 2008. Finally, 238 panic patients were included in this study. Their medical charts were retrospectively reviewed and reassessed by experienced psychiatrists to examine their clinical characteristics, demographic data and clinical course in repose to pharmacotherapy. Results : Among the 238 patients (121 males vs. 117 females), the mean age of disease onset was $41.3{\pm}12.7$ years and female patients showed 5 years older age of disease onset, compared with male patients. The mean score of PSR scale was $4.5{\pm}1.0$ at the first visit, reflecting a 'marked' level of severity of illness and impairment in functioning. Only 110 patients (46.4%) completed the whole follow up visits, whereas 128 patients (53.6%) dropped out during the treatment. After $17.7{\pm}0.5$ months of mean follow up period, the mean score of PSR scale at the last visit was reduced into $2.1{\pm}0.9$, reflecting a 'residual' severity of illness and impairment in functioning. The cumulative recovery rate was 62.1% in the completer group, whereas that of the drop-out group was 47.7%. Conclusions : The mean age of disease onset in Korean panic disorder patients who had visited university hospital was about 10 years older than that of Western panic disorder patients in previous studies, and the Korean panic disorder patients who had visited university hospital showed a relatively higher cumulative recovery rate. These differences might result from an ethnic difference in clinical characteristics and course in response to pharmacotherapy of panic disorder.

치료감호중인 조현병 환자에서 성격 평가 질문지를 이용한 정신병질적 성격평가

이미지(Mi-Ji Lee),홍성곤(Sung-Gon Hong),이재우(Jae-Woo Lee),권지현(JeeHyun Kwon),왕성근(Seung-Keun Wang),지익성(Ik-Seung Chee) 대한생물치료정신의학회 2012 생물치료정신의학 Vol.18 No.2

Objectives:This study was conducted to evaluate the validity of the Antisocial Features(ANT) scale of the Personality Assessment Inventory(PAI) with Psychopathic Personality Inventory-Revised(PPI-R) total score to assess psychopathy in Korean criminal offenders with schizophrenia. Methods:The subjects included 177 inpatients with schizophrenia who committed crimes. All subjects filled out PPI-R and PAI. The statistics are carried out by SPSS version 17.0. Results:The result shows that ANT scores are correlated highly with the PPI-R total score(r=0.56). Of the three subscales of ANT ; Egocentricity(ANT-E), Stimulus Seeking(ANT-S), Antisocial Behavior(ANT-A), ANT-E(r=0.53) and ANT-S(r=0.56) subscales showed strong correlations with PPI-R total score, and ANT-A (r=0.38) subscale was moderately associated with PPI-R total score. Among the 8 subscales of PPI-R, Rebellious Nonconformity(RN), Machiavellian Egocentricity(ME), Blame Externalization(BE) subscales were relatively strongly correlated with PAI scales ; ANT, ANT-E, and ANT-S. Between 2 factors of PPI-R, Self-Centered Impulsivity(SCI) factor showed relatively powerful association with ANT scale of PAI. ROC curve for ANT with PPI-R diagnoses of psychopathy tells that ANT scale dose not seem to make categorical prediction of psychopathy on PPI-R. Conclusions:ANT scale of PAI tapped primarily behavioral symptoms of psychopathy rather than interpersonal and affective symptoms. Despite of strong correlation between PPI-R total score and ANT score of PAI, the result of ROC curve suggests that it might be better to use ANT score as dimensional measure of psychopathy rather than categorical, in Korean criminal offenders with schizophrenia.

한국인 조현병 환자와 도파민 D2 수용체 유전자 다형성과의 관련연구

김태성,차승민,왕성근,김정란,이영호,최혜인,지익성,Kim, Tae-Sung,Cha, Seung-Min,Wang, Seong-Keun,Kim, Jeong-Lan,Lee, Young-Ho,Choi, Hye-In,Chee, Ik-Seung 대한생물정신의학회 2012 생물정신의학 Vol.19 No.1

Objectives : This study was designed to investigate the association between the dopamine D2 receptor (DRD2) genetic polymorphism [TaqIB (rs17294542) and TaqID (rs1800498)] and patients with schizophrenia. Methods : TaqIB (rs17294542) and TaqID (rs1800498) polymorphism of the DRD2 gene were typed in 100 patients with schizophrenia and 109 normal controls. Results : There were no statistical differences in genotype and allele distribution of TaqIB (rs17294542) and TaqID (rs1800498) genetic polymorphism between patients with schizophrenia and normal controls. Conclusions : These results suggest that the TaqIB (rs17294542) and TaqID (rs1800498) polymorphisms of the DRD2 gene may not be associated with schizophrenia in the Korean population.

정신분열병 환자 및 일차친족에서 신경학적 연성징후와 전두엽 관리 기능에 관한 연구

황복진(Bok-Jin Hwang),김정란(Jeong-Lan Kim),이선우(Sun-Woo Lee),지익성(Ik-Seung Chee),김수영(Soo-Young Kim),홍성곤(Sung-Gon Hong) 대한생물치료정신의학회 2007 생물치료정신의학 Vol.13 No.2

Objectives:This study was conducted to investigate if the neurological soft signs and dysfunction of frontal execution would be a potential marker of neurodevelopmental abnormalities in individuals with schizophrenia. Methods:We examined subjects using the Neurological Evaluation Scale(NES) and EXIT of Kims frontal executive neuropsychological test in 20 patients with schizophrenia, 20 of their first relatives, and 20 normal controls. Results:In terms of NES, it showed significant difference in Motor Coordination and Sequencing complex motor acts(Patients≥Relatives≥Controls) and Others of NES showed more frequently in Patients than Relatives and Controls. However, there is no difference in sensory Integration among the three groups. Total score of NES were the greatest in patients with schizophrenia, first degree Relatives had intermediate score(Patients>Relatives>Controls) (p<.0001). In regards to the quantity test of EXIT, Stroop, Word fluency, and Figure fluency were lower in Patients and Relatives than Controls, and Recognition were the lowest in Patients. Only Recognition efficiency was significantly lower in Patients than other groups(Patients≥Relatives≥Controls). Generally, EIQ was significantly lower in Patients than Relatives and Controls. Subtest of EXIT were negatively correlated with Motor Coordination, Sequencing complex motor acts, and Others of NES. Conclusion:Although there are a few limitations in this study, it is found that neurological soft signs have a significant correlation with frontal executive function in patients with schizophrenia and their first degree relatives and patients with schizophrenia have greater neurological soft signs and deficits of frontal execution than their relatives.

한국어판 Modified Mini-Mental State (3MS-K) Examination의 신뢰도와 타당도

김민구(Min-Goo Kim),이선우(Sun-Woo Lee),왕성근(Sung-Keun Wang),지익성(Ik-Sung Chee) 대한생물치료정신의학회 2005 생물치료정신의학 Vol.11 No.2

Objectives: The purpose of this study was to test the validity and reliability of the Korean version of Modified Mini-Mental State(3MS-K) examination. Methods: The subjects were total 76 patients in the psychiatric hospital and day hospital. All subjects were examined one Cognitive Examination of Cambridge Examination for the Mental Disorder of the Elderly(CAMCOG) by one rater, and also were examined two 3MS-K examinations and two Mini Mental State Examination(MMSE)s by two raters. Results: For reliability of 3MS-K, Cronbach alpha was 0.966, Pearson correlation coefficients for inter-rater reliability was 0.996(p<0.001). For item-total correlation coefficients in two raters were ranged between r=0.399 to r=0.921. Pearson correlation coefficients for the total scores between 3MS-K and CAMCOG in two raters, were 0.972 and 0.979 respectively. The cut-off scores of 71 had a sensitivity of 92% and a specificity of 93%, and the area under the Receiver Operating Characteristics(ROC) curve was 0.921. Conclusion: The results revealed that 3MS-K could be a reliable and valid tool for cognitive assesment. However, further study is in need to investigate it's clinical usefulness.