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1년간의 알렌드로네이트 투여와 운동프로그램이 골다공증 노인여성의 골밀도 수준과 관련변인에 미치는 효과
지용석(Ji Yong Seog),윤경재(Yun Gyeong Jae),변재종(Byeon Jae Jong),김명기(Kim Myeong Gi) 한국사회체육학회 2003 한국사회체육학회지 Vol.19 No.2
Although there were many studies about increasing the bone mineral density(BMD) of the elderly by exercise program, most of the physician have recommanded the pill, including estrongen, calcitonin, calcitrol, sodium fluoride, and bisphosphonates for increasing the BMD levels to osteoporotic patients. Among the pills, the alendronate have could increased bone mineral density(BMD) and prevent vertebral fractures radiographically than the other pills(Black et al, 1996). About this Black et al. study(1996) has demonstrated that the effect of alendronate on the risk of morphometric as well as clinically evident fractures in postmenopausal woman with low bone mass. However, the pills may be developed the side effect. Thus, using the pill is important, but the other therapy(e.g. regular exercise) is also very weighty. Therefore, for the purpose of reducing the dosage of pills, we examined the effect of exercise program on BMD level and related factors of the elderly taking the alendronate. The purpose of this study was to investigate the changes of BMD level and related factor(calcium mass, lean mass, fat mass, and body weight) in 34 elderly women after 1 year exercise program. Subjects were 34 women residing in Seoul-Seniors-Tower. Although all of the subjects have been taking the alendronate 10mg every day, these people were classified to two groups, who one group or exercise group(n=17) was participating in an exercise program for a year, and the other group or non-exercise group(n=17) was not in that program. The exercise group had taken part in exercise program 5 days per week. The results were as followed: 1. Changes of BMD levels through whole body scan. There were not significant(p>.05) differences in BMD levels between both groups before the exercise program. Also, there were not significant(p>.05) differences in BMD related factors between both groups after the exercise program. But after one year exercise programs, there were significant differences in Head(t=-2.194, p=0.043), Legs(t=-2.233, p=0.040), Trunk(t=-3.581, p=0.002), Ribs(t=-2.515, p=0.023), Pelvis9t=-3.631, p=0.002), and Spine(t=-4.590, p=0.001) in the exercise group. In fact we thick that the previous variables improved the T-score to 15.73%(t=-2.849, p=0.012). However, after one year experiment, there were significant differences in only Head(t=-2.938, p=0.010) in the control group. Thus, the T-score of the control group was not improved. 2. Changes of BMD related factors Although the calcium mass was not significant(p>.05) different between both groups, in times it was significantly increased 5.14%(t=-2.690, p=0.016) in an exercise group. Also, there were not significant differences in lean mass, fat mass, and body weight between or within groups. As a conclusion, although the alendronate is advantageous to the elderly people with osteoporosis, the method of exercise program combined the pill is more effective than the method of pill alone. In conclusion, we thick that if the osteoporotic patients must take in the alendronate, they must be participated in exercise program to reduce the dosage of pill and to gain the more benefit on BMD level and so on.
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