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단풍취로부터 분리한 Apigenin 7-O-β-D-glucoside 가 알콜대사효소에 미치는 영향
지옥표,신말식,문형인 한국농화학회 1999 Applied Biological Chemistry (Appl Biol Chem) Vol.42 No.2
Effects of compounds isolated from Ainsliaea acerifolia on alcohol metabolism in rats were examined and the results were as follows: Apigenin 7-O-β-D-glucoside, after a single oral administration to rats, was found to cause a significant decrease in the serum ethanol concentration as well as enhancement of liver cytosolic alcohol dehydrogenase(ADH) activity.
池玉杓 성균관대학교 약학연구소 1993 成均藥硏論文集 Vol.5 No.1
Eighty kinds of different plants were collected from the thirteen sites of South Korea. Two of them showed strong anti-HIV activity, CD_50: 383.0㎍/ml, ED_50: 55.4㎍/ml, SI: 3.59, through in vitro cell culture study. At same time, in vitro test of several murine and humane tumor cell lines were taken with these plants exctracts. Three of them indicated further studies with their significant activities.
문형인,지옥표,문세훈,신말식 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1
Spraque-Dawley계 수컷랫트에 계통분획한 단풍취의 각 분획물을 경구투여하고 혈청 ethanol농도와 간의 ADH활성에 미치는 효과를 검색 추적한 결과 알코올대사를 촉진시키는 성분은 주로 에탄올가용부에, 억제시키는 성분은 에탄올불용부에 주로 존재함을 추정할 수 있었고 현재 활성성분을 분리중에 있다.(1998년 9월 25일 접수, 1998년 10월 14일 수리) Effects of organic solvents fraction from Ainsliaea acerifolia ethanol extract on alcohol metabolism in rats were examined and the results were as follows: Ethanol souble fraction, after a single oral administration to rats, was found to cause a significant decrease in the serum ethanol concentration as well as enhancement of liver cytosolic alcohol dehydrogenase(ADH) activity, on the other hand, the fraction insouble in ethanol was found to cause an increase ethanol concentration in the blood and inhibit ADH activity.
노종화,지옥표,문형인,Roh, Jong-Hwa,Zee, Ok-Pyo,Moon, Hyung-In 한국생약학회 2000 생약학회지 Vol.31 No.2
The herb of Melampyrum roseum var. hirsutum Beauv. was extracted with methanol and the extract was fractionated with n-hexane, chloroform, ethylacetate and n-buthanol. Repeated column chromatography of silica gel, Sephadex LH-20 and Lobar-A lichroprep Si 60 led to the isolation of five compounds from n-hexane layer and ethylacetate layer. These compounds were identified as apigenin, linarin, pectolinarin, wogonin and mussaenoside, respectively, by the physicochemical and spectral properties.
오좌섭,지옥표,문형인,Oh, Joa-Sub,Zee, Ok-Pyo,Moon, Hyung-In 한국생약학회 2000 생약학회지 Vol.31 No.4
In search for plant-derived cytotoxic compounds, it was found that the $CHCl_3$ and EtOAC extracts obtained from the flowers of Paulownia coreana Uyeki (Scrophulariaceae) exhibited significant cytotoxic activity against human tumor cell lines, A549, SK-OV-3, SK-MEL-2, XF498, and HCT15. Activity-guided fractionation on the basis of the inhibitory activity against the growth of human tumor cell lines, in vitro, and repeated column chromatography afforded several cytotoxic compounds from P. coreana. The structures and stereochemistry of these compounds were established, on the basis of analysis of spectra including IR, UV, EI-MS, $^{1}H-NMR,\;^{13}C-NMR$ and some chemical transformations, as Compound PCCl $(2-hydroxy-4(15),11(13)-eudesmadien-8{\beta},12-olide)$, Compound $PCC2(2,3-dihydro-4-hydroxy-1(15),11(13)-xanthadien-8{\beta},12-olide)$, Compound PCE1 (chrysophanol), Compound PCE2 (emodin), Compound PCE3 (physcion). Cytotoxic activity of compounds obtained from P. coreana. on five tumor cells lines was evaluated by procedure of SRB methods.
이강노,지옥표,곽종환,박호진,심성보,구경아,윤현주 성균관대학교 약학연구소 1994 成均藥硏論文集 Vol.6 No.1
Polysaccharide fraction from the fruits of Xanthium strumarium(SLPI) was extracted and purified by sephadex gel filtration. SLP1 fraction was tested for the effects on the spleen cell culture in vitro. SLP1 allows growth of spleen cells up to 2 months in culture, suggesting the immunoregulatory activity of this polysaccharide fraction. The molecular weight of SLP1 fraction was found to be about 6,300 dalton by sephadex gel filtration chromatography using standard dextrans.