http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Adrenomedullin Deficiency Increases the Susceptibility of Liver Fibrosis Induced by CCl<SUB>4</SUB>
Ae-Ri Ji(지애리),Meeyul Hwang(황미열),Ah-Young Kim(김아영),Eun-Mi Lee(이은미),Eun-Joo Lee(이은주),Myeong-Mi Lee(이명미),Soo-Eun Sung(성수은),Sang-Hyeob Kim(김상협),Jin-Kyu Park(박진규),Kyu-Shik Jeong(정규식) 한국생명과학회 2015 생명과학회지 Vol.25 No.4
아드레노메둘린은 모든 조직에서 발현되는 펩타이드로 이 펩타이드 수용체가 간경화 유발 시 증가된다. 이번 연구에서는 사염화탄소(CCl4) 투여로 유도되는 간경화에서 아드레노메둘린의 효과를 아드레노메둘린 유전자 한쪽이 결핍된 생쥐에서 관찰하였다. 사염화탄소를 일회투여 받은 급성 군과 6주 동안 지속적으로 투여 받은 만성군으로 나누어 효과를 관찰하였다. 간경화 정도는 병리조직적 검사와 웨스턴 블롯 방법을 사용하여 측정하였다. 급성에서는 결핍된 생쥐와 야생형 생쥐에서 별다른 차이점이 없었다. 만성의 경우 아드레노메둘린이 결핍된 생쥐에서 심각한 간경화가 관찰되었다. 아스파르테이트 아미노전이요소(AST)와 알라닌 아미노전이요소(ALT) 수치가 아드레노메둘린이 결핍된 생쥐 군에서 높게 관찰되었다. 간경화 마커 단백질인 콜라젠, 알파-SMA과 TGF-beta가 아드레노메둘린이 결핍된 생쥐 군에서 높게 관찰되었다. 또한 아드레노메둘린 결핍 생쥐 군은 심각한 지질 과산화 반응이 확인되었고 이는 글루타시오 펄옥시다아제(GSH)의 감소가 원인이었다. 따라서 이 연구는 아드레노메둘린의 결핍은 사염화탄소로 유도된 간경화 감수성을 증가시키는 것으로 결론할 수 있다. 이로써 아드레노메둘린은 간경화 새로운 치료 타겟으로 사용될 수 있음을 나타낸다. Adrenomedullin (AM) is a peptide expressed in all body tissues, and its related receptors are increased in liver fibrosis. In this study, we evaluated the effect of AM deficiency on liver fibrogenesis induced by CCl4 using AM heterozygous (HT) mice. The animals received a single injection of CCl4 or olive oil for the acute experiment, and received CCl4 or olive oil three times a week for 6 weeks for the chronic experiment. Fibrosis was accessed using histopathological analysis and the western blot. The AM HT mice showed mild pericentrilobular degeneration when compared to the AM wild type (WT) mice. In the acute experiment, there was no significant difference between the AM WT and AM HT mice. However, in the chronic experiment, the CCl4-treated AM HT mice showed more severe liver fibrosis than that of the CCl4-treated AM WT mice. The AST and ALT levels of the AM HT CCl4 group were higher than those of the AM WT CCl4 group. Additionally, the collagen deposition, α-SMA protein and TGF-β protein were increased in the AM HT CCl4 group when compared to the AM WT CCl4 group. The AM HT mice also exhibited severe lipid peroxidation through the GSH decrement. Taken together, our data suggest that AM deficiency increases the susceptibility to liver fibrosis induced by CCl4, indicating a novel therapeutic target for patients with liver fibrosis.
Bovine Tuberculosis of Korean Native Cattle in an Abattoir
Seong-Jun Jang(장성준),Sun-Hee Do(도선희),Mi-Ran Ki(기미란),Il-Hwa Hong(홍일화),Jin-Kyu Park(박진규),Ae Ri Ji(지애리),Kyu-Shik Jeong(정규식) 한국생명과학회 2009 생명과학회지 Vol.19 No.12
소 결핵은 만성적으로 서서히 진행 되어 쇠약해 지기 때문에 일반적으로 사후 검시 후에 확인 된다. 소결핵의 감염이 대부분 폐에서 발생하기 때문에 심한 경우에는 기침, 비루 및 호흡 곤란을 유발 한다. 본 고에서는 도축장에서 나온 사체의 심장, 간, 신장, 폐, 복수, 임파선 및 내장에서 얻은 시료를 분석한 것이다. 사체의 부검 검시도중 다양한 모양과 크기의 결핵 병변이 관찰 되었다. 백색 크림 색깔의 결핵은 화농성으로 임파선, 폐 및 장간막을 포함하여 흉막강에 퍼져 있었다. 폐와 임파선의 그램 염색과 Ziehl-Neelsen’s acid-fast 염색 결과 강한 조직화학적 양성 반응을 나타내었다. Acid-fast에 염색된 유기체들이 현미경 검경에서 발견 되었다. 본 고에서는 의심원인체로 사료되는 Mycobacterium bovis의 조직학적 발견을 근거로 이에 의한 소결핵의 조직병리학적 소견을 보고하는 바이다. Bovine tuberculosis is generally detected postmortem because it is a chronic debilitating disease. Since tuberculosis is mainly found in the lungs, clinical signs including coughing, nasal discharge, and difficulty breathing can occur in severe instances. In the present study, specimens were collected from the heart, liver, kidney, lung, pleural cavities, lymph nodes and intestines of carcasses found in an abattoir. According to post-mortem examination and inspection of carcasses, tuberculosis lesions were varied in appearance and size. Tubercles of a white cream color were disseminated throughout the pleural cavity including the lymph nodes, lungs and mesentery containing pus. Gram and Ziehl-Neelsen’s acid-fast staining for the lung and lymph nodes revealed a highly positive histochemical reaction. The acid-fast organisms were observed histologically in the lesions under a microscope. This report demonstrated the histopathology of bovine tuberculosis based on the histological findings of Mycobacterium bovis, which is a suspected causative agent.
흰쥐 부분 근육 절제 모델에서 지방유래줄기세포의 치료 효과
황옥경 ( Ok Kyung Hwang ),홍일화 ( Il Hwa Hong ),기미란 ( Mi Ran Ki ),( Se Il Park ),박진규 ( Jin Kyu Park ),한정연 ( Jung Youn Han ),홍경숙 ( Kyung Sook Hong ),지애리 ( Ae Ri Ji ),정재호 ( Jae Ho Jeong ),강경선 ( Kyung Seon Ka 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.4
Adipose tissue derived stem cells(ASCs) are multipotent cells capable of forming bone, cartilage, and other connective tissues. In this study we evaluated the effect of stem cells derived from adipose tissue on the muscle regeneration in partial removed skeletal muscle in rats. Male sprague-dawley rats were randomly divided into three groups: control, PBS-injected and ASCs-injected group. Stem cells were isolated from rat abdominal adipose tissue by collagenase digestion and ASCs labeled with superparamagnetic iron oxide(Feridex) were used. Muscle injury was subjected to rat bypartial removal of quadriceps femoris muscle. The labeled cells were directly injected into the muscle injured area after muscle injury an hour. After 2 weeks, histological analysis was performed using H&E staining and prussian blue staining. The muscle regeneration markers were examined by immunohistochemistry and RT-PCR. ASCs labeled with Feridex were detected by prussian blue staining in injured muscle area. Microscopical muscle regeneration and neovascularization were more increased in ASCs-injected group compared to PBS-injected group. The expression level of Pax7, MyoD and myogenin were more significantly increased in ASCs-injected group compared with the PBS-injected group. This preliminary observation shows that ASCs may be directly involved in the regeneration process of injured skeletal muscle; therefore the possibility of using ASCs as a stem cell therapy for muscle regeneration need to be further investigated for the purpose of clinical trials.