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2D 형상을 갖는 Polydioxanone 세포지지체에서 공극크기에 따른 세포배양 특성평가
조아라(A Ra Jo),지민희(Min Hee Jee),정훈진(Hoon Jin Jung),홍명화(Myoung Wha Hong),윤지혜(Ji Hye Yun),김영율(Young-Yul Kim),조영삼(Young-Sam Cho) 대한기계학회 2012 대한기계학회 춘추학술대회 Vol.2012 No.11
In this study, cell-culturing characteristics are assessed with several different types of two dimensional polydioxanone(PDO) scaffolds. Firstly, 110㎛ and 230㎛-diameter PDO monofilaments are prepared. Secondly, PDO monofilaments with different diameter, respectively, are laid orthogonally having different pore sizes. On the other hand, two-dimension scaffolds, which having different pore sizes, are knitted using PDO monofilaments with different diameter, respectively. After that, adipose stem cell, adipose stem cell with Polydeoxyribonucleotide(PDRN), and adipose stem cell with platelet-rich plasma(PRP) are seeded on scaffolds to assess the cell-culturing characteristics.
김소연(So-Youn Kim),지민희(Min-Hee Jee),정훈진(Hoon Jin Jeong),이인환(In-Hwan Lee),이승재(Seung-Jae Lee) 대한기계학회 2013 대한기계학회 춘추학술대회 Vol.2013 No.12
Recent experimental researches support the hypothesis that mechanical stimuli play a role in regulating specialized molecules expression in articular cartilage in vitro and in vivo. Therefore we are studying bioreactor to provide a stimulus of mimicked real knee environment. Our bioreactor system consists of a joint motion stimulation device and culture chamber. We fabricated a stimulation system similar to movement of the CPM device for human joint motion. This system is composed of a linear stage, ball-spline and links. Also we fabricated a culture system for media circulation and mimicked knee environment. However, previous culture system has some problems that media leakage and interference of joint model. In this study, we improved a new-chamber system for non-interference of joint model and medium sealing. Then, this system could be used to investigate the effect of dynamic culture.
정훈진(Hoon Jin Jeong),지민희(Min-Hee Jee),김소연(So-Youn Kim),이승재(Seung-Jae Lee) 한국기계가공학회 2014 한국기계가공학회지 Vol.13 No.2
Recent experimental observations support the hypothesis that mechanical stimuli play a role in regulating the specialized molecular expression of articular cartilage in vitro and in vivo. Other studies have demonstrated that the continuous passive motion(CPM)bioreactor for whole joints can provide a platform for possible future in vitro studies and applications, including possible interactions of bio-mechanical and biochemical signals. In this study, we have developed acustom-made bioreactor capable of bending and stretching with circular type motion, and a biomimetic knee joint model, using a 3D printer. This system could be used to investigate the effects of rehabilitative joint motion of dynamic culture.