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다중예각 평면 교차전극을 이용한 입자 크기에 따른 측면방향 변위
한송이(Song-I Han),주영돈(Young-Dong Joo),한기호(Ki-Ho Han) 대한기계학회 2012 大韓機械學會論文集B Vol.36 No.3
본 논문에서는 유체흐름방향과 예각으로 놓여있는 평면 교차전극 위를 지나가는 입자의 크기에 따른 측면방향 변위에 대하여 소개한다. 아울러, 유체흐름방향과 평면 교차전극 사이의 각도에 따른 측면방향 변위의 변화를 보인다. 본 논문에서는 선전하(line charge) 모델을 이용하여 크기가 다른 세 종류의 형광 polystyrene(PS) 입자의 측면방향 변위를 이론적으로 예측하였다. 크기에 따른 입자의 측면방향 변위의 변화를 이용하여, 크기별로 입자를 연속적으로 분리할 수 있는 측면방향 유전영동 미세분리기를 개발하였다. 3, 5, 10 ㎛ PS 입자의 혼합물을 이용하여 분리한 실험결과로 부터 개발된 측면방향 유전영동 미세분리기는 3 ㎛ PS 입자를 99.86%, 5 ㎛를 98.82%, 10 ㎛를 99.69%의 높은 효율로 각각 분리할 수 있음을 확인하였다. 이로부터 제안된 측면방향 유전영동 미세분리기는 다종 혼합물로부터 다양한 크기의 입자들을 한 번에 분리하는 기술로 널리 활용될 수 있을 것으로 기대된다. This paper presents the lateral displacement of a particle passing over a planar interdigitated electrode array at an angle as a function of particle size. The lateral displacement was also measured as a function of the angle between the electrode and the direction of flow. A simplified line charge model was used for numerical estimation of the lateral displacement of fluorescent polystyrene (PS) beads with three different diameters. Using the lateral displacement as a function of particle size, we developed a lateral dielectrophoretic (DEP) microseparator, which enables the continuous discrimination of particles by size. The experiment using an admixture of 3-, 5-, and 10-㎛ PS beads showed that the lateral DEP microseparator could continuously separate out 99.86% of the 3-㎛ beads, 98.82% of the 5-㎛ beads, and 99.69% of the 10-㎛ beads. The lateral DEP microseparator is thus a practical device for the simultaneous separation of particles according to size from a heterogeneous admixture.
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특발성 과호산구 증후군 환자의 치료 도중 발생한 간혈종 1례
이영태,김동기,박지훈,김윤정,김기향,박보민,권민정,김애란,이원식,주영돈,손창학 白中央醫療院 2005 仁濟醫學 Vol.26 No.1
Idiopathic hypereosinophilic syndrome is characterized by marked elevation of eosinophil count ( >1,500/㎣) in peripheral blood without explaining etiology. It shows tissue involvement in many organs such as liver, G-I tract, myocar dium, lung, skin, kidney and nerve. Some case of hypereosinophilic syndrome with hepatic involvement have been reported, but not much. We have recently experienced a case with idiopathic hypereosinophilic syndrome of a 40 year old man who presented with RUQ pain. By abdominal CT, ill- defined subcapsular hematoma was detected. Liver biopsy showed eosinophilic infiltration within the portal tract and sinusoid. Drain procedure and corticosteroid adminiiatbrought marked improvement of clinical manifestation, hematologic abnormality and radiologic abnormality.
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이명수,주영돈,이재윤,김동수,이경순 인제대학교 1990 仁濟醫學 Vol.11 No.4
Takayasu 동맥염은 대동맥과 주분지 동맥의 협착성 병변을 특징으로 하는 원인 불명의 범동맥염으로서 저자들은 1981년부터 1990년까지 본원 내과에 입원하며 Takayasu 동맥염으로 진단된 12례를 검토하여 임상관찰 성적과 함께 문헌 고찰을 하였다. Takayasu's arteritis is an arteritis of undetemrined etiology, which affects the aorta and the proximal portion of its major branches. Authors experienced 12 cases who were admitted in Paik Hospital, Inje University, Pusan, Korea during 1981 and 1990. The result are as follows ; 1) Among 12 cases, 4 are males and 8 are females patient. 2) Visual disturbance, headache, absent or weak radial pulse and hypertension are common symptoms and 3) The aortographic findings are stenosis of occlusion of subclavian artery in 10 cases, abdo, aorta in 6 cases, descending aorta in 4 cases, renal artery in 4 cases, carotid artery in 3 cases, vertebral artery in 3 cases aortic arch in 3cases. 4) Involvement of the aorta was classfied as type I in 1 case, type II in 2 cases and then type III in 4 cases. 5) Left radial pulse was absent more frequently than right one.
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재발성 피부 혈관염으로 발현된 급성 골수세포성 백혈병 1 예
김석주,윤상조,주영돈,김두일,김동욱,손창학,강창일 인제대학교 1997 仁濟醫學 Vol.18 No.4
급성 골수성 백혈병 환자에서 비특이적 피부 혈관염이 발생하는 경우는 드물게 보고되고 있으며 특히 피부 혈관염이 초기 증상으로 발현되는 경우는 아직까지 국내에서 보고된 바 없다. 저자들은 재발성 피부 혈관염을 주소로 내원한 환자에서 급성 골수성 백혈병(FAB 분류, 아형 M2)으로 진단된 1예를 경험하였기에 문헌고찰과 함께 보고한다. Small-vessel vasculitis involving predominantly the skin belongs to the hypersensitivity group of vasculitides. The association between cutaneous vasculitis and myeloproliferative and lymphoproliferative malignancies has rarely been reported. For this reason, we describe a patient presenting with cutaneous vasculitis as the initial clinical manifestation in whom a diagnosis of acute myeloblastic leukemia was subsequently established by skin biopsy, peripheral blood smear and bone marrow biopsy examinations. There is no previous case report in Korea, so we report this case.
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급성 백혈병 관해유도요법후 발생한 다발성 비장농양 1예
이홍기,김선운,박경동,이현성,주영돈,손창학 인제대학교 2000 仁濟醫學 Vol.21 No.1
Splenic abscess is a rare illness. Its incidence has ranged from 0.14 to 0.7 % in various autopsies conducted in the US. Even in the most recently published articles, diagnosis was made only in autopsies in 37 % of the cases. While splenic abscess may arise occasionally from contiguous spread of infection or direct trauma to the spleen, usually it develops with hematogenous spread or infection. But, bacterial endocarditis is the most common cause. RUQ pain of abdomen developed in only half of series. Splenomegaly, fever and leucocytosis was also present. When splenic abscesses are being considered in a differential diagnosis, CT scan of the abdomen has been the most sensitive diagnostic tool. Streptococcal species are the most common bacterial isolates from splenic abscesses, S. aureus is the next most common. Salmonella species are seen commonly in patients with sickle cell hemoglobinopathy. Because of the high mortality related for splenic abscess, the treatment of choice is splenectomy with adjunctive antibiotics. However, percutaneous drainage has been successful alternative. We reported a 19-years old female patient who had splenic abscess after remission induction chemotherapy of acute leukemia, successfully treated with splenectomy.
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