The Association between Serum GGT Concentration and Diabetic Peripheral Polyneuropathy in Type 2 Diabetic Patients

조호찬 대한당뇨병학회 2010 Diabetes and Metabolism Journal Vol.34 No.2

Background: Diabetic peripheral polyneuropathy (DPP) is one of the common complications of diabetes mellitus (DM) and can lead to foot ulcers or amputation. The pathophysiology of DPP includes several factors such as metabolic, vascular, autoimmune,oxidative stress and neurohormonal growth-factor deficiency and recent studies have suggested the use of serum gammaglutamyl transferase (GGT) as an early marker of oxidative stress. Therefore, we investigated whether serum GGT may be useful in predicting DPP. Methods: We assessed 90 patients with type 2 DM who were evaluated for the presence of DPP using clnical neurologic examinations including nerve conduction velocity studies. We evaluated the association between serum GGT and the presence of DPP. Results: The prevalence of DPP was 40% (36 cases) according to clinical neurological examinations. The serum GGT concentration was significantly elevated in type 2 diabetic patients with DPP compared to patients without DPP (P < 0.01). There were other factors significantly associated with DPP including smoking (P = 0.019), retinopathy (P = 0.014), blood pressure (P < 0.05),aspartate aminotransferase (P = 0.022), C-reactive protein (P = 0.036) and urine microalbumin/creatinine ratio (P = 0.004). Serum GGT was independently related with DPP according to multiple logistic analysis (P < 0.01). Conclusion: This study shows that increased levels of serum GGT may have important clinical implications in the presence of DPP in patients with type 2 diabetes.

The Relationship among Homocysteine, Bilirubin, and Diabetic Retinopathy

조호찬 대한당뇨병학회 2011 Diabetes and Metabolism Journal Vol.35 No.6

Background: Diabetic retinopathy is a common microvascular complication of diabetes mellitus (DM) and the leading cause of blindness in adults. Homocysteine, a risk factor with toxic effects on vascular endothelial cells, and bilirubin, a protectant with antioxidant and anti-inflammatory properties on the vasculature, have been reported to be linked to vaso-occlusive disorders. Therefore, the author of the present study investigated the association between the levels of plasma homocysteine and serum total bilirubin and the incidence of diabetic retinopathy as a chronic microvascular complication in patients with type 2 diabetes mellitus (T2DM). Methods: A total of 102 patients with T2DM who visited our hospital from January 2009 to January 2010 were assessed. Results: Of the 102 patients, the prevalence of diabetic retinopathy was 67 cases (65.7%) according to clinical ophthalmic examination. The duration of DM (P<0.001), age (P=0.003), fasting blood glucose (P=0.045) and urine albumin-creatinine ratio (P=0.015) in univariate analysis and plasma homocysteine level (P=0.038), duration of DM (P=0.001), and total bilirubin level (P=0.012) in multiple logistic regression analysis were statistically significantly associated with the incidence of diabetic retinopathy. Conclusion: The present study indicates that homocysteine and bilirubin may be useful biomarkers for increased risk of diabetic retinopathy since retinopathy in patients with T2DM was linked to higher plasma homocysteine level and decreased serum total bilirubin level.

폐경후 여성 제2형 당뇨병 환자에서 α-lipoic Acid 투여가 혈관내피세포기능에 미치는 영향

조호찬,김미정,김혜순,이상준,윤태승,김성재,김상현,허승호,문교철,배재훈,이인규 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.26 No.4

우연히 발견된 악성 갈색세포종 제거 후 당뇨병이 완치된 1예

조호찬 ( Ho Chan Cho ),김혜순 ( Hye Soon Kim ),김윤정 ( Yoon Jung Kim ),하유진 ( Yu Jin Hah ),김남경 ( Nam Keong Kim ),김미경 ( Mi Kyung Kim ),박근규 ( Keun Gyu Park ),김용훈 ( Yong Hoon Kim ),권선영 ( Sun Young Kwon ) 대한당뇨병학회 2007 Diabetes and Metabolism Journal Vol.31 No.6

류마티스관절염 환자에서 종양궤사인자 차단제 사용 후에 발생한 폐렴 2예

원희관 · 이재광 · 허지안 · 조호찬 · 김현숙 조선대학교 의학연구원 2008 The Medical Journal of Chosun University Vol.33 No.3

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건강검진에서 시행한 갑상선기능검사 이상에 대한 고찰

박지은,조호찬 대한갑상선학회 2012 International Journal of Thyroidology Vol.5 No.1

Background and Objectives: Thyroid disorders are common endocrine disease with various clinical symptoms. Biochemical function tests are important to detect thyroid function disorders, but guideline for screening of thyroid dysfunction is controversial. Therefore, in this study, we aimed to investigate the prevalence and clinical significance of thyroid dysfunctions with analyses of public screening and follow-up results on our hospital. Materials and Methods: This study was performed on 3309 subjects (1753 men, 1556 women) that visited in our health promotion center for periodic health examination from January to June 2007, with review of medical records. Serum T3, Free T4, and thyroid-stimulating hormone concentrations were measured with radioimmunoassay using commercial kits, and ultrasonogram and scan of thyroid were conducted if needed. Results: The study showed the prevalence of thyroid dysfunction was 11.8% (389 cases) and among the subjects, prevalence of undiagnosed hyperthyroidism and hypothyroidism were 1.8% (7 cases) and 3.1% (12 cases), subclinical hyperthyroidism and subclinical hypothyroidism was 0.5% (2 cases) and 4.9% (19 cases). However, prevalence of normal thyroid function with follow up clinically was 37.3% (145 cases). Conclusion: This study indicates significance of screening and confirmation through follow-up for thyroid disorders with high prevalence of thyroid dysfunctions with guidelines to minimize the false positive results.

고속 채널로써 전력선 특성 분석

박종연,조호찬,이혁순 江原大學校 産業技術硏究所 2001 産業技術硏究 Vol.21 No.A

For the power line communication, we studied its characteristic impedance, noise characteristics, loss characteristics and the coupling circuit between the communication MODEM and power lines. As the results of the experiments, we concluded that the power line impedance in a house varied in the wide range because the electric systems generate the current and voltage hamornic noises.

Cerivastatin이 혈중 근효소에 미치는 영향

김상현,서창균,조호찬,이승현,윤태승,허지안,조주연,박재호 啓明大學校 醫科大學 2002 계명의대학술지 Vol.21 No.1

Statin이 혈중 근효소에 미치는 영향을 알아보기 위하여 이 연구를 시행하였으며, cerivastatin을 사용한 환자 군에서 다른 statin 사용 군보다 의미 있는 CK 및 AST치의 상승을 보였다(p<0.05). 또한 CK가 기준치보다 3배 이상 증가된 환자도 cerivastatin을 사용한 환자 군에서는 발생하였으나, 다른 statin 사용 군에서는 발생하지 않았다(p<0.05). Hypercholesterolemia is firmly established as a risk factor for the development of atherosclerosis. Cerivastatin is a third generation statin, a synthetic HMG-CoA reductase inhibitor which lowers plasma cholesterol level by inhibiting endogenous cholesterol synthesis. It has also been reported that cerivastatin is relatively well tolerated and has a low incidence of adverse effects. It has been also reported that less than 1% of the patients treated with cerivastatin experienced clinically significant elevation of muscle enzymes. The purpose of this study was to investigate the effect of cerivastatin on serum muscle enzymes. The patients with primary hypercholesterolemia were treated with statin at least 4 weeks in Keimyung University Dongsan Medical Center. We compared the effect of Cerivastatin treatment (group A, 33 patients) on changes of muscle enzymes including creatine kinase (CK), aspartate transaminase (AST) and lac-tate dehydrogenase (LDH) with other statin treatment group (group B, 46 patients). The group A produced statistically significant elevation of CK and AST (p<0.05) after treatment with cerivastatin when compared to the group B. More than three fold elevation of CK level was developed only in the group A (p=0.02). These results indicate that cerivastatin induces higher incidence of muscle enzymes elevation than other statins.

HID Lamp용 전자식 안정기의 시뮬레이터 개발

장목순,조계현,조호찬,박종연 한국조명전기설비학회 2002 조명·전기설비학회논문지 Vol.16 No.2

전자식 안정기는 자기식 안정기에 비해서 고주파로 점등하기 때문에 방전등에서 나타나는 음향 공명 현상으로 인한 Arc의 떨림이 나타날 수는 있으나 소형, 경량화 및 조광 기능을 가질 수 있음으로 인해서 그 응용분야가 더욱 더 넓어지고 있다. 본 논문에서는 일반적으로 글 알려져 있는 수은 램프 모델링을 응용하여 메탈 할라이드 램프의 모델링을 만들고램프에서 발생하는 음향 공명 현상을 해소하기 위해 음향 공명의 영향을 반지 않는 동작 주파수를 설정하였다. 또한 새로운 방법의 출력 회로(LCC)의 선계 방법을 다루었다. 또한 SIMULINK를 이용하여 메탈할라이드 램프를 사용한 전자식 안정기 시물레이터를 제작하였고, 이를 통해서 쉽게 인버터 출력부LCC값을 결정하였고 시뮬레이션 특성은 실제 안정기를 제작한 후 결과 값을 비교함으로써 시뮬레이터 특성을 검증하였다. The electronic ballast have much more shaking of arc than magnetic ballast because of acoustic resonance phenomenon. but it has used mare than before. In this paper, we made metal halide lamp modeling by modifying modeling of mercury lamp. To avoid acoustic resonance phenomenon, We calculated acoustic resonance frequency band. We proposed design of LCC circuit. Also, electronic ballast simulator for metal halide lamp was developed by simulink LCC parameters of inverter was decided on the basis of simulation results. After development of prototype ballast, it was verified the characteristics of simulator.

전염성 단핵구증에 병발한 급성 간염 1례

이석근,이영석,조호찬,허정욱,안성훈,박승국 啓明大學校 醫科大學 2001 계명의대학술지 Vol.20 No.2

Infectious mononucleosis is characterized by fever, sore throat, lymphadenopathy, atypical lymphocytosis and heterophil antibody. Icteric hepatitis is rare in infectious mononucleosis. We report a patient with icteric infectious mononucleosis hepatitis. The diagnosis of infectious mononucleosis was confirmed by the demonstration of high serum titier of antibodies against Epstein-Barr virus antigens. Epstein-Barr virus infection causing hepatitis should be suspected when tests for other hepatotrophic viral infections were negative.