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상부위장관질환의 조직염증 정도와 Helicobacter pylori 감염에 따른 혈청 가스트린치의 변화
이성화(Sung Hwa Lee),정을조(Eul Jo Chung),김수진(Soo Jin Kim),강석진(Seok Jin Kang),정기욱(Kee Wook Jung),이경원(Gyeong Won Lee),하종(Jong Ha),조활석(Hwal Suk Cho),정운태(Woon Tae Jung),조중현(Jung Hyeun Cho) 대한소화기학회 2000 대한소화기학회지 Vol.36 No.3
Background/Aims : It is well known that serum gastrin titers in patients infected with Helicobacter pylori (H. pylori) are much higher than those in uninfected asymptomatic controls. The aim of this study was to investigate the relationship between serum gastrin titers and histologic scorings according to disease entities in Koreans. Methods: Ninty-nine patients infected with H. pylori and 35 uninfected patients were enrolled in this study and their serum gastrin titers were measured by 125I radioim- munoassay. The H. pylori infection was determined by rapid urease test and histology. Results: No significant differences in serum gastrin titers were noted between the 99 patients infected with H. pylori and the 35 uninfected patients. Serum gastrin titers in the all patients infected with H. pylori were significantly higher in the fundus of high chronic lymphocyte infiltration score than in the fundus of low chronic lymphocyte infiltration score (55.1±45.8 pg/mL vs 22.9±15.0 pg/mL, p<0.05). In addition, serum gastrin titers in the uninfected patients were significantly higher in the fundus of high chronic lymphocyte infiltration score than in the fundus of low chronic lymphocyte infiltration score. Conclusions: Serum gastrin titers were significantly high in high histologic score group. However, they were not significantly increased by H. pylori infection or gastroduodenal disease entities. Therefore, there is no direct correlation between H. pylori infection and hypergastrinemia. (Kor J Gastroenterol 2000;36:326 - 335)